Light aversion in mice depends on nonimage-forming irradiance detection.

Detection of light in the eye underlies image-forming vision, but also regulates adaptive responses in physiology and behavior. Typically these adaptive responses do not involve image-forming vision, but depend on a relatively absolute measure of brightness (nonimage-forming irradiance detection). The goal of this study was to further understand how image-forming vision and nonimage-forming irradiance detection contribute to the effects of light on behavior. Three light dependent behaviors were assessed in wild-type, Rpe65-/- and rd1 mice. In Rpe65-/- mice, nonimage-forming irradiance detection is severely attenuated, but rod based visual acuity is relatively preserved. In rd1 mice visual acuity is nonrecordable, but nonimage-forming responses are less severely attenuated than Rpe65-/-. Positive masking, an image-forming vision dependent increase in wheel running, was absent in rd1 and restricted to higher irradiances in Rpe65-/-. Negative masking, a suppression of wheel running sensitivity with nonimage-forming irradiance detection input, was increased in rd1, but reduced in Rpe65-/- mice. By contrast, light aversion, an avoidance of brightly lit areas, was abolished in both Rpe65-/- and rd1. This shows that image-forming vision is not sufficient for light aversion, suggesting nonimage-forming irradiance detection motivates this behavior. Further, the differing effects of disease suggest that negative masking and light aversion are distinct responses with specialized nonimage-forming irradiance detection pathways. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognitive control factors in speech perception at 11 months.

The development of speech perception during the 1st year reflects increasing attunement to native language features, but the mechanisms underlying this development are not completely understood. One previous study linked reductions in nonnative speech discrimination to performance on nonlinguistic tasks, whereas other studies have shown associations between speech perception and vocabulary growth. The present study examined relationships among these abilities in 11-month-old infants using a conditioned head-turn test of native and nonnative speech sound discrimination, nonlinguistic object-retrieval tasks requiring attention and inhibitory control, and the MacArthur-Bates Communicative Development Inventory (L. Fenson et al., 1993). Native speech discrimination was positively linked to receptive vocabulary size but not to the cognitive control tasks, whereas nonnative speech discrimination was negatively linked to cognitive control scores but not to vocabulary size. Speech discrimination, vocabulary size, and cognitive control scores were not associated with more general cognitive measures. These results suggest specific relationships between domain-general inhibitory control processes and the ability to ignore variation in speech that is irrelevant to the native language and between the development of native language speech perception and vocabulary. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Engineered clay products for the paper industry

The need for kaolin pigments by the paper industry with controlled optical and physical properties have significantly changed the type of filler and coating clays available to the paper industry. Processing equipment now used in the production of kaolin products is much more sophisticated and controllable than in the past. Better understanding of the mineralogy and the physical and chemical properties of kaolins, in addition to improved processing techniques, has allowed the kaolin processors to produce engineered or tailored grades that meet particular needs of the user. Particle size and shape, brightness, gloss, opacity, and viscosity can be altered and controlled to meet specific requirements of the paper coater. Examples of several types of engineered products available for use by the paper industry are discussed.     

Visualising things. Perspectives on how to make things public through visualisation

In this paper, we will be discussing how visualisations can facilitate participatory processes by way of conveying issues of public concern as ‘things’. In the line of Latour’s plea to ‘make things public’, visualisations can be purposefully designed to trigger and encourage public debates concerning a wide range of issues. For this, we explore how a visualisation can be both transparent (i.e. visualising the complex entanglement of backstories of an issue) and readable. Specifically, we clarify the aspect of designing a readable visualisation of ‘things’. First, drawing from different fields of literature (i.e. Information Visualisation, Science and Technology Studies and Human-Computer-Interaction) we will articulate three main aspects of readability: engaging people to interact with a visualisation of complex issues, supporting sense making and encouraging reflection. Then, based on three empirical case studies, we indicate different design considerations in terms of engaging people to interact with a visualisation: contextualising a visualisation (via its location or medium), staging interaction and allowing people to provide their own perspective on the issue displayed. As a conclusion we propose a scenario that allows the visualisation to gradually become more transparent in support of its readability.     

13.3% efficient solution deposited Cu(In,Ga)Se2 solar cells processed with different sodium salt sources

In this work, we obtain the highest reported power conversion efficiency (13.3%) for sulfur‐free CIGSe solar cells by solution processing. Intentional sodium incorporation is achieved directly by dissolving sodium salts in the ink. The effect on solar cell properties of three sodium sources is investigated: NaCl, NaHCO₂, and NaSCN. A comparison is made with absorbers grown on soda‐lime glass substrates and in the absence of sodium sources. The incorporation via sodium salts yields significantly better results, which is attributed to enhanced‐sodium availability. A comparison with identically annealed sputtered metal precursor layers capable of delivering 15.1% module efficiency suggests that the cell results are limited by the selenization procedure. Copyright © 2015 John Wiley & Sons, Ltd.     

High-Rate Uncorrelated Bit Extraction for Shared Secret Key Generation from Channel Measurements

Secret keys can be generated and shared between two wireless nodes by measuring and encoding radio channel characteristics without ever revealing the secret key to an eavesdropper at a third location. This paper addresses bit extraction, i.e., the extraction of secret key bits from noisy radio channel measurements at two nodes such that the two secret keys reliably agree. Problems include 1) nonsimultaneous directional measurements, 2) correlated bit streams, and 3) low bit rate of secret key generation. This paper introduces high-rate uncorrelated bit extraction (HRUBE), a framework for interpolating, transforming for decorrelation, and encoding channel measurements using a multibit adaptive quantization scheme which allows multiple bits per component. We present an analysis of the probability of bit disagreement in generated secret keys, and we use experimental data to demonstrate the HRUBE scheme and to quantify its experimental performance. As two examples, the implemented HRUBE system can achieve 22 bits per second at a bit disagreement rate of 2.2 percent, or 10 bits per second at a bit disagreement rate of 0.54 percent.     

Fabrication of CdSe‐Nanofibers with Potential for Biomedical Applications

The design and synthesis of nanostructured functional hybrid biomaterials are essential for the next generation of advanced diagnostics and the treatment of disease. A simple route to fabricate semiconductor nanofibers by self‐assembled, elastin‐like polymer (ELP)‐templated semiconductor nanoparticles is reported. Core–shell nanostructures of CdSe nanoparticles with a shell of ELPs are used as building blocks to fabricate functional one‐dimensional (1D) nanostructures. The CdSe particles are generated in situ within the ELP matrix at room temperature. The ELP controls the size and the size‐distribution of the CdSe nanoparticles in an aqueous medium and simultaneously directs the self‐assembly of core–shell building blocks into fibril architectures. It was found that the self‐assembly of core–shell building blocks into nanofibers is strongly dependent on the pH value of the medium. Results of cytotoxicity and antiproliferation of the CdSe‐ELP nanofibers demonstrate that the CdSe‐ELP does not exhibit any toxicity towards B14 cells. Moreover, these are found to be markedly capable of crossing the cell membrane of B14. In contrast, unmodified CdSe nanoparticles with ELPs cause a strong toxic response and reduction in the cell proliferation. This concept is valid for the fabrication of a variety of metallic and semiconductor 1D‐architectures. Therefore, it is believed that these could be used not only for biomedical purposes but for application in a wide range of advanced miniaturized devices.     

Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening

A simple steady‐state kinetic high‐throughput assay was developed for the salicylate synthase MbtI from Mycobacterium tuberculosis, which catalyzes the first committed step of mycobactin biosynthesis. The mycobactins are small‐molecule iron chelators produced by M. tuberculosis, and their biosynthesis has been identified as a promising target for the development of new antitubercular agents. The assay was miniaturized to a 384‐well plate format and high‐throughput screening was performed at the National Screening Laboratory for the Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases (NSRB). Three classes of compounds were identified comprising the benzisothiazolones (class I), diarylsulfones (class II), and benzimidazole‐2‐thiones (class III). Each of these compound series was further pursued to investigate their biochemical mechanism and structure–activity relationships. Benzimidazole‐2‐thione 4 emerged as the most promising inhibitor owing to its potent reversible inhibition.