The incorporation of yield surface distortion into a unified constitutive model,part 2: Predictive capabilities

Summary The MATMOD-4V-DISTORTION model has been derived [1] with the intent of improving the MATMOD-4V model by adding the capability to predict distortions of small strain offset yield surfaces. This model is compared against a variety of experimental data to verify its behavior. Model simulations are compared with experimental data for proportional and nonproportional prestress histories and the effect of yield definition is also investigated. Finally, the same model which predicts a flattening of the yield surface in space is used to predict a rotation of the yield surface in ₁-₂ coordinates.With 9 Figures     

Stromdichte- und Magnetfeldverteilung bei einer Anordnung aus Platten und vielen parallelen Stromleitern

Übersicht Die vorliegende Arbeit befaßt sich mit der gesamten Stromdichte- und Magnetfeldverteilung in vielen flachen leitenden Platten konstanter Permeabilität, die bei einer Anordnung aus diesen Platten und vielen parallelen stromführenden Leitern angeordnet in mehreren Lagen entsteht. Unter Anwendung der Maxwellschen Differentialgleichungen und durch Einführung des Vektorpotentials werden allgemeine Gleichungen für die Komponenten der magnetischen Induktion im zweidimensionalen Feldraum aufgestellt. Die Stromdichteverteilung in den leitenden Platten, in denen Wirbelströme entstehen, wird aus dem Vektorpotential hergeleitet. Zunächst werden die Platten unendlich lang angenommen und die entsprechenden Gleichungen in Integralform aufgestellt, für deren Lösung die Gauss-Laguerresche Methode angewandt wird. Dann werden die Platten beiderseits durch Eisenwände begrenzt, womit die Gleichungen unter Berücksichtigung der Randbedingungen in Summenform ausgedrückt werden.

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Distribution of current and magnetic field density in flat conductive plates in an array composed from plates and many parallel conductors

Contents In the present research work the overall distribution of current and magnetic field density in many flat plates of constant magnetic permeability has been investigated, which applies to an array composed from the flat plates and many parallel conductors installed in many layers. Use of Maxwell's differential equations and vector potential results in general equations for the components of magnetic density in two dimensional field space. The distribution of current density in the conductive plates, where eddy currents are taken into account, is obtained from the vector potential. Initially the flat plates are considered being of infinite length, and with appropriate arrangement of the boundary conditions, the model applies to flat plates limited to both sides by iron partitions. Examples are given for both cases, where for the plates of infinite length the Gauss-Laguerre method is applied.

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Liste der Symbole A Vektorpotential - B Magnetische Induktion - I ₁ Stromstärke eines Leiters - N ₁ Anzahl der parallelen Leiter - N ₂ Anzahl der parallelen Platten - Permeabilität des Plattenmaterials - _r Relative Permeabilitätskonstante des Plattenmaterials - Leitfähigkeit - b Breite des Hauptstreukanals - i Stromdichte der Platten samt Wirbelströme - h ₁ Höhe der Leiter - a ₁ Breite der Leiterlagen - a Plattendicke - s Breite des Nebenstreukanals - c Abstand der letzten Platte von der Eisenwand - g Plattenhöhe - x, z, , Dimensionen - Q, K Integrationskonstanten - k ganze Zahl     

A combinatorial study of the rigidity of planar structures

Summary A combinatorial method is presented for examining the rigidity of planar structures. In this approach, an expansion process is used for the formation of a statically determinate substructure, known as a -tree of a structure. The algorithm of Lováz and Yemini, and the method of Sugihara are employed for the recognition of the elementary subgraphs, during this process.With 4 Figures     

Acoustic waves in solids with random cavities,II: Energy density considerations

Summary The propagation of acoustic plane and line-polarized waves in an isotropic solid containing random cavities is studied theoretically and experimentally. The effect of the cavities on the energy density and macroscopic propagation parameters of the acoustic waves is considered and the relationships between the cavities volume concentration, their average dynamic shape factor and the dynamic overall stiffness moduli of the solid are derived in the long wave approximation.     

Adenovirus-Mediated Inducible Expression of a PD-L1 Blocking Antibody in Combination with Macrophage Depletion Improves Survival in a Mouse Model of Peritoneal Carcinomatosis

Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a growing number of malignancies. However, overcoming primary or secondary resistances is difficult due to pharmacokinetics issues and side effects associated with high systemic exposure. Local or regional expression of monoclonal antibodies (mAbs) using gene therapy vectors can alleviate this problem. In this work, we describe a high-capacity adenoviral vector (HCA-EFZP-aPDL1) equipped with a mifepristone-inducible system for the controlled expression of an anti-programmed death ligand 1 (PD-L1) blocking antibody. The vector was tested in an immune-competent mouse model of colorectal cancer based on implantation of MC38 cells. A single local administration of HCA-EFZP-aPDL1 in subcutaneous lesions led to a significant reduction in tumor growth with minimal release of the antibody in the circulation. When the vector was tested in a more stringent setting (rapidly progressing peritoneal carcinomatosis), the antitumor effect was marginal even in combination with other immune-stimulatory agents such as polyinosinic-polycytidylic acid (pI:C), blocking mAbs for T cell immunoglobulin, mucin-domain containing-3 (TIM-3) or agonistic mAbs for 4-1BB (CD137). In contrast, macrophage depletion by clodronate liposomes enhanced the efficacy of HCA-EFZP-aPDL1. These results highlight the importance of addressing macrophage-associated immunoregulatory mechanisms to overcome resistance to ICIs in the context of colorectal cancer.     

From Natural Methylation to Versatile Alkylations Using Halide Methyltransferases

Halide methyltransferases (HMTs) enable the enzymatic synthesis of S-adenosyl-l -methionine (SAM) from S-adenosyl-l -homocysteine (SAH) and methyl iodide. Characterisation of a range of naturally occurring HMTs and subsequent protein engineering led to HMT variants capable of synthesising ethyl, propyl, and allyl analogues of SAM. Notably, HMTs do not depend on chemical synthesis of methionine analogues, as required by methionine adenosyltransferases (MATs). However, at the moment MATs have a much broader substrate scope than the HMTs. Herein we provide an overview of the discovery and engineering of promiscuous HMTs and how these strategies will pave the way towards a toolbox of HMT variants for versatile chemo- and regioselective biocatalytic alkylations.     

高强度高压绝缘子产品质量同其结构性能的重要关系(续)——制造者和用户应共同掌握的规则和指标(第二部分)

6　各种电瓷结构分析实例证实结构的差别下面介绍各种电瓷结构分析的结果。从扫描电镜照片 (ＲＥＭ)的判读中可见到这些材料的差别。试样ａ:日本瓷绝缘子Ｃ1 1 0 /1 1 2 ,制造年代 1 997试样ｂ :西门子瓷绝缘子Ｃ1 2 0 ,Ｃ1 3 0 ,制造年代 2 0 0 1试样ｃ:高强度矾土瓷绝缘子 ,西门子 2 0 0 1开发陶瓷岩相试样的制备系经多级金刚石研磨和抛光以及化学浸蚀。为判定气孔状态 ,对磨片作了透光照片 ,在其光亮区放大倍数为 1 0 0∶1 ,而且扫描电镜照片放大倍数为2 0 0∶1。图 5ａ　试样ａ光片的ＬＭ(透光显微镜 )和ＲＥＭ(扫描电镜 )图象 ,放大倍…     

Characterization of poly(diethoxyphosphazene) by size exclusion chromatography and viscometry

Two samples of poly(diethoxyphosphazene) (PDEP) having very different molecular weights have been studied by viscometry and size exclusion chromatography in THF solution. The results obtained, together with light scattering data of these samples, allow the calculation of the Mark-Houwink constants a=0.65 and K=2.5 10^-4 in THF at 25°C. The method of calculation employed takes into account the great polydispersity of the samples. The characteristic ratio of the unperturbed dimensions was also calculated giving C_n = r²_o/n² 18, a value slightly higher than those previously reported for poly(dihexoxyphosphazene), C_n13 and poly (dichlorophosphazene), C_n13.5.     

Modelling the effects of human papillomavirus in cervical cells

Worldwide, cervical cancer is the second most common cancer in women, after breast cancer. The prevalence of this malignant disease is estimated at 1.4 million cases worldwide, causing about 290,000 deaths and 500,000 new cases per year, of which 80% correspond to women living in developing countries. In this work we propose a family of ordered models for basal cells of the cervix corresponding to different stages ranging from normal cells to the formation of precancerous lesions. We analyse the first member of the family analytically and for the second member we developed a non-standard numerical method in order to extract some biological information.