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991.
Sensors: 6‐Mercaptopurine‐Induced Fluorescence Quenching of Monolayer MoS2 Nanodots: Applications to Glutathione Sensing,Cellular Imaging,and Glutathione‐Stimulated Drug Delivery (Adv. Funct. Mater. 41/2017) 下载免费PDF全文
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Yanlin Li Wenduo Jiang Yue Feng Lei Wu Yimin Jia Ruqian Zhao 《International journal of molecular sciences》2022,23(11)
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat deposition in the liver, which is often associated with disrupted iron homeostasis. Betaine has been reported to be hepatoprotective, yet whether and how betaine ameliorates high-fat diet-induced disruption of hepatic lipid and iron homeostasis remains elusive. In this study, mice were fed either standard (CON) or high-fat diet (HFD) for 9 weeks to establish a NAFLD model. Mice raised on HF diet were then assigned randomly to HF and HFB groups, HFB group being supplemented with 1% (w/v) of betaine in the drinking water for 13 weeks. Betaine supplementation significantly alleviated excessive hepatic lipid deposition and restored hepatic iron content. Betaine partly yet significantly reversed HFD-induced dysregulation of lipogenic genes such as PRARγ and CD36, as well as the iron-metabolic genes including FPN and HAMP that encodes hepcidin. Similar mitigation effects of betaine were observed for BMP2 and BMP6, the up-stream regulators of hepcidin expression. Betaine significantly rectified disrupted expression of methyl transfer gene, including BHMT, GNMT and DNMT1. Moreover, HFD-modified CpG methylation on the promoter of PRARγ and HAMP genes was significantly reversed by betaine supplementation. These results indicate that betaine alleviates HFD-induced disruption of hepatic lipid and iron metabolism, which is associated with modification of CpG methylation on promoter of lipogenic and iron-metabolic genes. 相似文献
994.
Weikai Ding Yousef Sultan Shumei Li Wenjun Wen Bangjun Zhang Yiyi Feng Junguo Ma Xiaoyu Li 《International journal of molecular sciences》2022,23(11)
Previous studies have indicated that the harmful heavy metal lead (Pb) contamination in aquatic systems has caused intelligence development disorders and nervous system function abnormalities in juveniles due to the increased permeability of the blood–brain barrier. Ionic liquids (ILs) are considered “green” organic solvents that can replace traditional organic solvents. Studies have found the presence of ILs in soil and water due to chemical applications or unintentional leakage. Therefore, what would happen if Pb interacted with ILs in a body of water? Could ILs enable Pb to more easily cross the blood–brain barrier? Therefore, we examined the combined exposure of Pb and ILs in common carp at low concentration (18.3 mg L−1 of Pb(CH3COO)2•3 H2O and 11 mg L−1 of the IL 1-methyl-3-octylimidazolium chloride, 5% of their LC50) for 28 days in the present study. The result of a neurobehavioral assay showed that chronic exposure of lead at lower concentrations significantly altered fish movement and neurobehaviors, indicating that lead exposure caused neurotoxicity in the carp. Increases in the neurotransmitter dopamine levels and injuries in the fish brain accounted for neurobehavioral abnormalities induced by lead exposure. Moreover, we also found that lead could easily cross the blood–brain barrier and caused significant bioaccumulation in the brain. Particularly, our study indicated that the ionic liquid could not synergistically promote blood–brain barrier permeability and hence failed to increase the absorption of lead in the fish brain, suggesting that the combined exposure of lead and ILs was not a synergistic effect but antagonism to the neurotoxicity. The results of this study suggested that ILs could recede the Pb induced neurotoxicity in fish. 相似文献
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[本刊讯] 2007年9月18日国家发展改革委、国家统计局发布2007年第61号公告《千家企业能源利用状况公报(2007)》(简称:公报).千家企业指钢铁、有色金属、石油石化、化工、建材、煤炭、电力、造纸、纺织等9个重点耗能行业中,年综合能源消费量18万t标准煤以上的企业,全国共998家.…… 相似文献
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德国的LUWOGE公司是巴斯夫公司的住宅开发公司,在其设计的现代化的低能耗住宅内,用于取暖的燃料量平均仅为5 L/m2·a. 相似文献
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物联网终端安全接入认证是保证电力物联网大规模建设的关键性技术.传统认证方案通常采用的椭圆曲线密码算法,计算量大,不能抵抗量子攻击.数论研究单元算法可以抵抗量子攻击,与椭圆曲线密码采用点乘算法相比,计算速度快.因此提出了一种时间变换数论研究单元算法物联网动态安全接入认证算法,使用动态变化时间序列通过哈希函数产生动态密钥,... 相似文献
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