没有规矩不成方圆 不懂规则不“喝咖啡”

现在不少朋友都在电脑中安装了McAfee(麦咖啡),人们都说它功能非常强大,为什么自己的McAfee却并没那么强劲呢?其实,除了你没有及时更新病毒库外,McAfee最强大的规则设置你没有用好。下面就来看看两个规则设置实例,帮助你掌握它的规则设置方法。     

为私密文件养只大狼狗

数据安全问题越来越受到重视,如果平时不重视自己的数据安全,你便有可能成为下一个"艳照门"受害者!如何保护自己的机密数据呢?除了养成良好的使用电脑习惯外,为你的机密数据养条看门的"大狼狗"(下载地址:http://www.dalanggou.com/web/index.php,快车代码:CF0810CMRJ11)也是一个有效的防范手段."大狼狗"是一款非常出色的免费数据加密软件,使用起来也非常简单。     

听外语歌曲So Easy!

我喜欢听外国歌,很多朋友也和我一样,开始并不知道在哪里能获取最新的外语歌曲,这里也推荐给大家使用酷狗音乐盒。下载安装好酷狗音乐盒(下载地址:http://download.kugou.com/2008.快车代码:CF0810SZDM02)。运行软件后,点击"音乐"按钮,打开Web窗格。在窗格中点击"排行榜"标签,这时你就可以看到"酷狗日韩榜"和"酷狗英文榜,点击后就可以看到近期好听的日、韩、英语歌了,想听哪首点击就会开始     

你用的是高档的大闸蟹吗? Realtek集成声卡也分高中低档

众多主板上标识着采用高档HDAudio音效芯片,ALC888,而各大媒体也统一说辞,凡提及HDAudio必说到采用最好的ALC888,且不谈集成声卡是否音质够好,ALC888真的是集成声卡里最好的吗?实际上大家都被欺骗了,888其实是     

Mixed reality depth contour occlusion using binocular similarity matching and three-dimensional contour optimisation

Virtual Reality - Mixed reality applications often require virtual objects that are partly occluded by real objects. However, previous research and commercial products have limitations in terms of...     

A series of nanoparticles with phase-separated structures by 1,1-diphenylethene controlled one-step soap-free emulsion copolymerization and their application in drug release

A facile one-step approach to synthesize various phase-separated porous, raspberry-like, flower-like, core–shell and anomalous nanoparticles and nanocapsules via 1,1-diphenylethene (DPE) controlled soap-free emulsion copolymerization of styrene (S) with glycidyl methacrylate (GMA), or acrylic acid (AA) is reported. By regulating the mass ratio of S/GMA, transparent polymer solution, porous and anomalous P(S-GMA) particles could be produced. The P(S-GMA) particles turn from flower-like to raspberry-like and then to anomalous structures with smooth surface as the increase of divinylbenzene (DVB) crosslinker. Transparent polymer solution, nanocapsules and core–shell P(S-AA) particles could be obtained by altering the mole ratio of S/AA; anomalous and raspberry-like P(S-AA) particles are produced by adding DVB. The unpolymerized S resulted from the low monomer conversion in the presence of DPE aggregates to form nano-sized droplets, and migrates towards the external surfaces of the GMA-enriched P(S-GMA) particles and the internal bulk of the AA-enriched P(S-AA) particles. The nano-sized droplets function as in situ porogen, porous P(S-GMA) particles and P(S-AA) nanocapsules are produced when the porogen is removed. This novel, facile, one-step method with excellent controllability and reproducibility will inspire new strategies for creating hierarchical phase-separated polymeric particles with various structures by simply altering the species and ratio of comonomers. The drug loading and release experiments on the porous particles and nanocapsules demonstrate that the release of doxorubicin hydrochloride is very slow in weakly basic environment and quick in weakly acidic environment, which enables the porous particles and nanocapsules with promising potential in drug delivery applications.

Open image in new window

     

Electrochemical corrosion behavior of 2A02 Al alloy under an accelerated simulation marine atmospheric environment

The corrosion behavior of 2A02 Al alloy under simulated marine atmospheric environment has been studied using mass-gain, scanning electron microscope/energy dispersive spectroscopy (SEM/EDS), laser scanning confocal microscopy, X-ray diffraction spectroscopy and localized electrochemical methods. The results demonstrate that the relationship between the corrosion induced mass-gain and the corrosion time is in accordance with the power rule. The mass-gain increases gradually during the corrosion time, while the corrosion rate decreases. With ongoing of the corrosion, corrosion products film changed from a porous to a compact structure. The various spectroscopic data show that the corrosion products films composed mainly of Al(OH)₃, Al₂O₃ and AlCl₃. The electrochemical corrosion behavior of the 2A02 Al alloy was studied by electrochemical impedance spectroscopy (EIS).     

DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles

A series of bis(hydroxymethyl)-substituted imidazoles, thioimidazoles, and pyrrolizines and related bis(carbamates), linked to either 9-anilinoacridine (intercalating) or 4-(4-quinolinylamino)benzamide (minor groove binding) carriers, were synthesized and evaluated for sequence-specific DNA alkylation and cytotoxicity. The imidazole and thioimidazole analogues were prepared by initial synthesis of [(4-aminophenyl)alkyl]imidazole-, thioimidazole-, or pyrrolizine dicarboxylates, coupling of these with the desired carrier, and reduction to give the required bis(hydroxymethyl) alkylating moiety. The pyrrolizines were the most reactive alkylators, followed by the thioimidazoles, while the imidazoles were unreactive. The pyrrolizines and some of the thioimidazoles cross-linked DNA, as measured by agarose gel electrophoresis. Strand cleavage assays showed that none of the compounds reacted at purine N7 or N3 sites in the gpt region of the plasmid gpt2Eco, but the polymerase stop assay showed patterns of G-alkylation in C-rich regions. The corresponding thioimidazole bis(carbamates) were more selective than the bis(hydroxymethyl) pyrrolizines, with high-intensity bands at 5'-NCCN, 5'-NGCN and 5'-NCGN sequences in the PCR stopping assay ( indicates block sites). The data suggest that these targeted compounds, like the known thioimidazole bis(carbamate) carmethizole, alkylate exclusively at guanine residues via the 2-amino group, with little or no alkylation at N3 and N7 guanine or adenine sites. The cytotoxicities of the compounds correlated broadly with their reactivities, with the bis(hydroxymethyl)imidazoles being the least cytotoxic (IC50s >1 microM; P388 leukemia) and with the intercalator-linked analogues being more cytotoxic than the corresponding minor-groove-targeted ones. This was true also for the more reactive thioimidazole bis(carbamates) (IC50s 0.8 and 11 microM, respectively), but both were more active than the analogous "untargeted" carmethizole (IC50 20 microM). The bis(hydroxymethyl)pyrrolizine analogues were the most cytotoxic, with IC50s as low as 0.03 microM.     

图的正交(g,f)-因子分解

设ｇ和ｆ分别是定义在图Ｇ的顶点集合Ｖ（Ｇ）上的整数值函数且对每一个ｘ∈Ｖ（Ｇ）有２≤ｇ（ｘ）≤ｆ（ｘ）．证明了若Ｇ是（ｍｇ＋ｍ－１,ｍｆ－ｍ＋１）—图,则对Ｇ中任意一个给定的有ｍ条边的子图Ｈ,Ｇ有一个（ｇ,ｆ）—因子分解与Ｈ正交．