Regulation and Reconstruction of Cell Phenotype Gradients Along the Tendon-Bone Interface

Tendon–bone interface is prevalent in the human body. It is divided into four zones: tendon (soft tissue), unmineralized fibrocartilage, mineralized fibrocartilage, and bone (hard tissue). Tendon–bone interface is characterized by a cell phenotype gradient that appears in the different zones. The cell phenotype gradients at the tendon–bone interface are orchestrated by specific intracellular molecular mechanisms, extracellular factors, immune signals, and neurovascular factors. These features have inspired scientists to design systems that mimic natural cell phenotype gradients. These biomimetic systems include the construction of cell sheets, regulation of cellular microenvironments, and the design of gradient functional scaffolds. Exploration of methods to mimic cell phenotype gradients is instructional for future clinical applications in reconstituting the tendon–bone interface. The present review elucidates the gradient composition of the tendon–bone interface. The associated regulatory mechanisms and applications are discussed, with the anticipation of creating a mise en scène for future research in interface tissue engineering.     

An 8-Bit Digitally Controlled Programmable Phase Shifter Circuit for Sinusoidal Signals with 252∘ Phase Control Range

In this paper, the synthesis, design, and implementation of a programmable phase shifter circuit for sinusoidal signals is presented. The proposed circuit, built-up herein with operational amplifiers (OPAMPs), high precision resistors and low voltage switches, consists of a digitally controlled amplitude attenuator in combination with a single-tone orthogonalizer. Experimental results agree with theoretical background: the attained phase range was 252^° in 256 steps with a median step of 0.9^°. The inaccuracy of the circuit was determined to be of 0.03 %. Contrary to other OPAMP approaches for sinusoidal signals reported in the literature and based on a first-order all-pass filter structure, the approximation suggested in this work is based on a different concept. The achieved results demonstrate the functionality of the system for the case of a sinusoidal signal with frequency of 1 kHz. Notwithstanding, the proposed architecture can be extended to operate at higher frequencies by using different building blocks with larger bandwidth. Furthermore, it can be extended as well to work out with other periodic input waveforms, like triangular shapes or square waves, with the use of an appropriate orthogonalizer.     

制药工厂洁净室的压差控制

分析介绍了制药工厂洁净室压差控制的目的和作用以及制药工厂相关规范标准中压差控制的目标要求;结合中国新版GMP中压差控制的要求,对制药工厂洁净室压差控制的方法与措施进行了探讨。     

有机显示浮出水面

介绍了有机显示技术的优势及其应用领域。     

一种分形图像编码的快速算法

分形图像编码是近年来研究十分活跃的一种图像压缩编码方法.在分形图像编码中,由于值块与域块的匹配搜索计算量很大,导致分形编码速度较慢,不能适应图像实时传输的场合.本文分析了值块、域块之间的距离与值块的和值、域块的和值之间的关系,并由此提出了一种分形编码的快速算法.仿真结果表明,使用这种快速分形编码方法,可以减小搜索时间,较大程度地提高分形编码的速度,且解码图像的质量受影响甚少.     

Integration of Stiff Graphene and Tough Silk for the Design and Fabrication of Versatile Electronic Materials

The production of structural and functional materials with enhanced mechanical properties through the integration of soft and hard components is a common approach to Nature's material design. However, directly mimicking these optimized design routes in the lab for practical applications remains challenging. For example, graphene and silk are two materials with complementary mechanical properties that feature ultrahigh stiffness and toughness, respectively. Yet, no simple and controllable approach is developed to homogeneously integrate these two components into functional composites, mainly due to the hydrophobicity and chemical inertness of graphene. In this study, well‐dispersed and highly stable graphene/silk fibroin (SF) suspension systems are developed, which are suitable for processing to fabricate polymorphic materials, such as films, fibers, and coatings. The obtained graphene/SF nanocomposites maintain the electronic advantages of graphene, and they also allow tailorable mechanical performance to form including ultrahigh stretchable (with a strain to failure to 611 ± 85%), or high strength (339 MPa) and high stiffness (7.4 GPa) material systems. More remarkably, the electrical resistances of these graphene/SF materials are sensitive to material deformation, body movement, as well as humidity and chemical environmental changes. These unique features promise their utility as wearable sensors, smart textiles, intelligent skins, and human–machine interfaces.     

更换旧蓄电池组应注意的安全问题

先期使用的大批阀控式密封铅酸蓄电池(VRLA电池),及固定型防酸隔爆式铅酸蓄电池(GGF电池)由于各种原因容量下降,不能保证其正常使用需进行更换。本文对如何安全可靠进行新旧蓄电池组的更换割接提出建议。     

雷达目标空频域瞬态极化特性及其在几何结构反演中的应用

该文针对高分辨全极化成像雷达体制,研究了雷达目标的空频域瞬态极化特性及其在目标几何结构反演中的应用.给出了空频域瞬态极化特性的表征及获取方法,将已有瞬态极化理论拓广至空频域,并对典型散射结构的空频域瞬态极化特性进行对比分析.作为应用,提出基于空频域瞬态极化特性分析的雷达目标几何结构反演方法,该方法通过揭示空频域瞬态极化特征与散射结构类型间的对应关系,可以克服传统反演的模糊性和局限性,实现更为准确和可信的反演.基于暗室测量数据验证了该方法的有效性.     

An Investigation on the Coupled Thermal–Mechanical–Electrical Response of Automobile Thermoelectric Materials and Devices

Thermoelectric (TE) materials, which can directly convert heat to electrical energy, possess wide application potential for power generation from waste heat. As TE devices in vehicle exhaust power generation systems work in the long term in a service environment with coupled thermal–mechanical–electrical conditions, the reliability of their mechanical strength and conversion efficiency is an important issue for their commercial application. Based on semiconductor TE devices wih multiple p–n couples and the working environment of a vehicle exhaust power generation system, the service conditions of the TE devices are simulated by using the finite-element method. The working temperature on the hot side is set according to experimental measurements, and two cooling methods, i.e., an independent and shared water tank, are adopted on the cold side. The conversion efficiency and thermal stresses of the TE devices are calculated and discussed. Numerical results are obtained, and the mechanism of the influence on the conversion efficiency and mechanical properties of the TE materials is revealed, aiming to provide theoretical guidance for optimization of the design and commercial application of vehicle TE devices.