具有高可调增益范围的CMOS宽带中频调制器

利用TSMC 0 .2 5 μmCMOS混合工艺 ,针对超外差结构的无线宽带收发器 ,实现了一个能够工作在 5 0～6 0 0MHz的中频调制器 ,并对该调制器进行了仿真和测试。由于该调制器在输出端采用了一个具有高可调增益范围而且鲁棒性能好的可变增益放大器 (VGA) ,从而使得该调制器具有超过 70dB的增益可调范围。测试结果表明 ,该调制器能够工作在 5 0～ 6 0 0MHz的频率上 ,输出功率为 - 81～ - 10dBm ,最小增益的输出噪声为 - 130dBm/ Hz,最大增益的输出P1dB点为 - 4 .3dBm ,在 3V的电源电压下 ,电流功耗为 32mA。     

Targeted Nanoparticle‐Mediated Gene Therapy Mimics Oncolytic Virus for Effective Melanoma Treatment

Oncolytic virus has potential applications in cancer therapy. However, its clinical application is restricted by the virus‐associated biosafety issues. Here, inspired by the key role of vesicular stomatitis virus matrix protein (VSVMP) in the oncolytic vesicular stomatitis virus (VSV) induced apoptosis, a targeted nanoparticle‐delivered neutral VSVMP gene formulation is designed to act like the VSV for cancer therapy. This VSVMP formulation consists of a CRGDKGPDC peptide modified hybrid monomethoxy poly (ethylene glycol)‐poly(d ,l ‐lactide) nanoparticles complexed with VSVMP plasmid, having good blood compatibility and tumor targeting ability. The transfection efficiency is as high as that of VSV. After intravenous administration, the VSVMP formulation can efficiently target the tumor, significantly inhibit the melanoma growth and metastasis, prolong the survival time of tumor‐bearing mice, and does not cause obvious systemic toxicity. The anticancer mechanisms involve apoptosis induction, angiogenesis inhibition and some virus‐associated signal pathways activation. This work demonstrates a VSV‐inspired nonviral gene therapy that has promising clinical applications in melanoma treatment.     

关于MPEG-2空域时域自适应错误隐藏算法

MPEG-2的压缩算法,由于采用可变字长编码使得其对信道错误十分敏感,即使单比特错误都有可能导致图像质量的严重下降,使部分或整条信息丢失。在解码端的错误隐藏技术是解决这个问题的有效方法之一。该文基于图像像素间的最大光滑连接,利用丢失宏块的邻域宏块的全部信息,导出了加权内插的错误隐藏公式。提出了一种自适应的错误隐藏方法,序列中的第一帧使用空域信息重构丢失的区域,其它帧使用本文建议的空域时域自适应错误隐藏方法。仿真实验的结果表明本文建议的算法优于一些传统算法。     

Gradient Fusion Method for Night Video Enhancement

To resolve video enhancement problems, a novel method of gradient domain fusion wherein gradient domain frames of the background in daytime video are fused with nighttime video frames is proposed. To verify the superiority of the proposed method, it is compared to conventional techniques. The implemented output of our method is shown to offer enhanced visual quality.     

一种新型半波长可调滤波器设计

将Ba0.6Sr0.4TiO3(BST)铁电薄膜应用于微带电路中,采用高频仿真软件(HFSS)双模法提取耦合系数,快速设计了λ/2(λ为波长)可调滤波器。针对电路中偏压隔离部分设计了用于谐振器间的高阻偏压连线和λ/4接地线,使滤波器能采用端口加压的方式调谐,简化了调谐方式。最终设计了中心频率为7.8GHz、带宽为1GHz的带通可调滤波器。     

基于DC-SAM液位识别模型的非满管流量计

在工业生产过程中超声流量计凭借非接触测量、适用多种流体介质等优点发挥着重要作用。针对目前超声流量检测抗干扰能力差,检测精度较低等问题,提出了一种结合模式识别的四声道非满管超声流量计;该系统通过带浮点运算的高性能ARM处理器进行FFT运算,求出四声道的综合流速;配合边缘计算芯片来识别出管道的液位,并基于液位修正模型提升识别稳定性。在液位识别模型中利用特征提取模块和空间注意力机制模块来提取有效特征,使用随机森林进行液位分类。实验结果表明,DC-SAM算法相对于其他模型更快收敛,准确率达到96.6%;该系统在流量实验中,对比标定流量计能达到96.5%的准确度,且具有较好的线性度;可以准确识别液位和流量,在保持较高测量精度的同时满足检测的稳定性要求。     

中兴通讯CDMA2000 ALL-IP灵活的组网解决方案

CDMA2000 ALL-IP产品推出了包含Ap接口在内的ALL-IP接口解决方案,丰富了网络架构.中兴通讯CDMA2000 ALL-IP产品技术先进,容量大,接口协议丰富,具有兼容性和演进性.描述了中兴通讯CDMA2000ALL-IP网络灵活的组网方案,主要针对CDMA网络演进到LMSD阶段后,分析实现BSC与核心网之间A接口分组传输后带来的一系列网络架构优势,组网方式的灵活.     

Hierarchically Responsive Tumor-Microenvironment-Activated Nano-Artificial Virus for Precise Exogenous and Endogenous Apoptosis Coactivation

Targeting apoptotic pathways in tumor cells is recognized as a potent anticancer strategy. However, monotherapies that target a single apoptotic pathway often do not meet expectations and the nonspecific and uncontrolled activation of apoptotic pathways can overshadow potential application prospects. Here, a novel tumor-microenvironment-activated nano-artificial virus (TMAN) with hierarchically responsive capacity is fabricated and loaded with the plasmid encoding tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and mitochondria-targeted red fluorescent phototoxic protein (KillerRed) simultaneously for precise and controllable exogenous and endogenous apoptosis coactivation. The inert TMAN is endowed with in vivo longevity and undergoes orderly acidity-triggered deshielding of a masking layer, enzyme-responsive charge-reversal, and oxidative stress-sensitive structural fragmentation in the tumor extra/intracellular microenvironment to exert precise tumor recognition, deep penetration, cellular internalization, rapid endosomes escape, and effective gene release ability, leading to the effective and tumor-specific delivery of payloads. Given the virtues of TMAN, a favorable collaboration of TRAIL-triggered exogenous apoptosis and mitochondria-targeted KillerRed induced endogenous apoptosis is achieved synchronously under the control of light irradiation, thus remarkably improving antitumor efficacy with minimal toxicity. Taken together, this strategy highlights the significance of exogenous and endogenous apoptosis coactivation in cancer treatments and offers a promising paradigm for precise exo/endogenous dual-augmented antitumor therapy.     

激光焊接工艺参数对NiTi形状记忆合金焊缝成形的影响

采用Nd∶YAG连续激光器对2mm厚NiTi形状记忆合金(SMA)进行激光焊接。研究了激光焊接过程中激光功率、焊接速度、离焦量、侧吹保护气流量等主要工艺参数对焊缝成形的影响。结果表明,激光功率、焊接速度、离焦量等工艺参数的合理匹配是实现NiTi合金良好焊缝成形的关键因素。线能量为59～75.6J/mm时能获得最佳焊缝成形;离焦量在-2～3mm时均能使厚度2mmNiTi合金试件焊透,其中离焦量在0～1mm可以得到最佳焊缝成形;当侧吹气流量为15～20L/min时,气体保护效果和焊缝成形最好。通过大量工艺实验得到2mm厚NiTi合金焊接速度与激光功率的不同匹配对焊缝成形影响的曲线,为NiTi合金焊接加工及工程应用提供参考。