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21.
MA Steller KJ Gurski M Murakami RW Daniel KV Shah E Celis A Sette EL Trimble RC Park FM Marincola 《Canadian Metallurgical Quarterly》1998,4(9):2103-2109
Human papillomavirus (HPV) infection has been causally associated with cervical cancer. We tested the effectiveness of an HLA-A*0201-restricted, HPV-16 E7 lipopeptide vaccine in eliciting cellular immune responses in vivo in women with refractory cervical cancer. In a nonrandomized Phase I clinical trial, 12 women expressing the HLA-A2 allele with refractory cervical or vaginal cancer were vaccinated with four E786-93 lipopeptide inoculations at 3-week intervals. HLA-A2 subtyping was also performed, and HPV typing was assessed on tumor specimens. Induction of epitope-specific CD8+ T-lymphocyte (CTL) responses was analyzed using peripheral blood leukapheresis specimens obtained before and after vaccination. CTL specificity was measured by IFN-gamma release assay using HLA-A*0201 matched target cells. Clinical responses were assessed by physical examination and radiographic images. All HLA-A*0201 patients were able to mount a cellular immune response to a control peptide. E786-93-specific CTLs were elicited in 4 of 10 evaluable HLA-A*0201 subjects before vaccination, 5 of 7 evaluable HLA-A*0201 patients after two vaccinations, and 2 of 3 evaluable HLA-A*0201 cultures after all four inoculations. Two of three evaluable patients' CTLs converted from unreactive to reactive after administration of all four inoculations. There were no clinical responses or treatment toxicities. The ability to generate specific cellular immune responses is retained in patients with advanced cervical cancer. Vaccination with a lipidated HPV peptide epitope appears capable of safely augmenting CTL reactivity. Although enhancements of cellular immune responses are needed to achieve therapeutic utility in advanced cervical cancer, this approach might prove useful in treating preinvasive disease. 相似文献
22.
Moss C.D. Teixeira F.L. Yang Y.E. Jin Au Kong 《Geoscience and Remote Sensing, IEEE Transactions on》2002,40(1):178-186
A three-dimensional (3D) finite-difference time-domain (FDTD) scheme is introduced to model the scattering from objects in continuous random media. FDTD techniques have been previously applied to scattering from random rough surfaces and randomly placed objects in a homogeneous background, but little has been done to simulate continuous random media with embedded objects where volumetric scattering effects are important. In this work, Monte Carlo analysis is used in conjunction with FDTD to study the scattering from perfectly electrically conducting (PEC) objects embedded in continuous random media. The random medium models under consideration are chosen to be inhomogeneous soils with a spatially fluctuating random permittivities and prescribed correlation functions. The ability of frequency averaging techniques to discriminate objects in this scenarion is also briefly investigated. The simulation scheme described in this work can be adapted and used to help in interpreting the scattered field data from targets in random environments such as geophysical media, biological media, or atmospheric turbulence 相似文献
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二过碘酸合银(Ⅲ)钾引发丙类酸甲酯在淀粉上接枝共聚合反应的研究 总被引:2,自引:0,他引:2
研究了由二过碘酸合银(Ⅲ)钾(简称Ag(Ⅲ))与可溶性淀粉组成的氧化还原体系,于碱性介质中引发淀粉的接枝共聚合反应,得到高接枝效率的接枝共聚物,测定了引发剂浓度、单体浓度、pH值和反应温度对接枝参数的影响,并探讨了引发机理。 相似文献
25.
Overview of ship-design expert systems 总被引:1,自引:0,他引:1
Expert systems constitute a branch of artificial intelligence, and their unique characteristics enable computer systems to perform at the level of a human expert by the use of algorithms that can capture domain-specific knowledge. Through an extensive survey of research about ship-design expert systems, we conclude that although development and implementation of expert systems for ship design offer substantial barriers, the shipbuilding industry needs them nonetheless. We examine the major reasons that use of expert systems in this industry has lagged behind. These include the problems of integration with existing computer-aided design systems, problems of knowledge representation and sizable development costs. We discuss in detail some key factors that can lead to the solution of these problems. 相似文献
26.
Development of the Chinese Scientometric Indicators (CSI) 总被引:1,自引:0,他引:1
We describe the Chinese Scientometric Indicators (CSI), an indicator database derived from the Chinese Science Citation Database (CSCD). Its design is supported by the Natural Sciences Foundation of China (NSFC). In this indicator database data of a statistical nature are organized and categorized leading to ranked lists and providing bases for comparisons among Chinese institutions and regions. 相似文献
27.
行波热声驱动器的性能分析 总被引:1,自引:0,他引:1
在简单介绍行波热声驱动器的研究历史、工作机理及其与驻波型热声驱动器的区别之后,着重对环路部分的性能进行了预测分析,并给出一些有益的结论。 相似文献
28.
Flame structure and NO emission characteristics in counterflow diffusion flame of blended fuel of H2/CO2/Ar have been numerically simulated with detailed chemistry. The combination of H2, CO2 and Ar as fuel is selected to clearly display the contribution of hydrocarbon products to flame structure and NO emission characteristics due to the breakdown of CO2. A radiative heat loss term is involved to correctly describe the flame dynamics especially at low strain rates. The detailed chemistry adopts the reaction mechanism of GRI 2.11, which consists of 49 species and 279 elementary reactions. All mechanisms including thermal, NO2, N2O and Fenimore are taken into account to separately evaluate the effects of CO2 addition on NO emission characteristics. The increase of added CO2 quantity causes flame temperature to fall since at high strain rates a diluent effect is prevailing and at low strain rates the breakdown of CO2 produces relatively populous hydrocarbon products and thus the existence of hydrocarbon products inhibits chain branching. It is also found that the contribution of NO production by N2O and NO2 mechanisms are negligible and that thermal mechanism is concentrated on only the reaction zone. As strain rate and CO2 quantity increase, NO production is remarkably augmented. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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