Exosomes Derived from Mesenchymal Stem Cells

The functional mechanisms of mesenchymal stem cells (MSCs) have become a research focus in recent years. Accumulating evidence supports the notion that MSCs act in a paracrine manner. Therefore, the biological factors in conditioned medium, including exosomes and soluble factors, derived from MSC cultures are being explored extensively. The results from most investigations show that MSC-conditioned medium or its components mediate some biological functions of MSCs. Several studies have reported that MSC-derived exosomes have functions similar to those of MSCs, such as repairing tissue damage, suppressing inflammatory responses, and modulating the immune system. However, the mechanisms are still not fully understood and the results remain controversial. Compared with cells, exosomes are more stable and reservable, have no risk of aneuploidy, a lower possibility of immune rejection following in vivo allogeneic administration, and may provide an alternative therapy for various diseases. In this review, we summarize the properties and biological functions of MSC-derived exosomes and discuss the related mechanisms.     

Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats

In the present study, post inflammation irritable bowel syndrome (PI-IBS) rats were firstly established by intracolonic instillation of acetic acid with restraint stress. Then the pharmacokinetics of berberine in the rat plasma were compared after oral administration of berberine hydrochloride (25 mg/kg) to normal rats and PI-IBS rats. Quantification of berberine in the rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples were collected at 15 different points in time and the pharmacokinetic parameters were analyzed by WinNonlin software. Compared with the normal group, area under the plasma concentration vs. time curve from zero to last sampling time (AUC_0–t) and total body clearance (CL/F) in the model group significantly increased or decreased, (2039.49 ± 492.24 vs. 2763.43 ± 203.14; 4999.34 ± 1198.79 vs. 3270.57 ± 58.32) respectively. The results indicated that the pharmacokinetic process of berberine could be altered in PI-IBS pathological conditions.     

Functional Composite Adsorbents Based on Metal-Organic Frameworks in a Carbon Matrix Applied for Methane Storage

Protection of Metals and Physical Chemistry of Surfaces - In the present work, a method for producing new shaped composite materials by introducing a metal-organic framework structure Cu-BTC110...     

Vapor-Phase Protection of Zinc from Atmospheric Corrosion by Low-Volatile Corrosion Inhibitors

Protection of Metals and Physical Chemistry of Surfaces - The atmospheric corrosion resistance of metals can be reached by the formation of ultrathin protective films on their surface. Over recent...     

高层转换结构设计探究

本文充分考虑到了高层转换结构设计的安全问题,并结合工程实例,就可能出现的缺陷及设计时应注意的方面展开了详细论述,使其能同时满足建筑功能和结构规范的要求。希望在成功总结了高层转换结构设计中的重点后,对于设计人员起到一定的指导作用。     

浅析光伏建筑结构一体化的发展及应用

大多数建筑物的形式都分为这样几类：传统的泥瓦墙建筑形式、木结构建筑、新型光伏建筑等形式。本文详细评测了光伏建筑结构的一体化发展现状以及实际的运用情况。     

孔子的工匠观

该文依据《论语》等先秦古籍,从工匠造物必须诚信、必须敬业、必须重视改进工具等13个方面论述了孔子的工匠思想。