Two faces of competition: target‐mediated reverse signalling in microRNA and mitogen‐activated protein kinase regulatory networks

Biomolecular regulatory networks are organised around hubs, which can interact with a large number of targets. These targets compete with each other for access to their common hubs, but whether the effect of this competition would be significant in magnitude and in function is not clear. In this review, the authors discuss recent in vivo studies that analysed the system level retroactive effects induced by target competition in microRNA and mitogen‐activated protein kinase regulatory networks. The results of these studies suggest that downstream targets can regulate the overall state of their upstream regulators, and thus cannot be ignored in analysing biomolecular networks.Inspec keywords: reviews, RNA, molecular biophysics, enzymesOther keywords: target‐mediated reverse signalling, mitogen‐activated protein kinase regulatory networks, biomolecular regulatory networks, microRNA regulatory networks, review, in vivo study     

Synthesis of Co/SiO2 hybrid nanocatalyst via twisted Co3Si2O5(OH)4 nanosheets for high-temperature Fischer-Tropsch reaction

A cobalt-silica hybrid nanocatalyst bearing small cobalt particles of diameter ～5 nm was prepared through a hydrothermal reaction and hydrogen reduction.The resulting material showed very high CO conversion (＞82％) and high hydrocarbon productivity (～1.0 gHc·g-1cat,·h-11) with high activity (～8.5 x 10-5 molco·g-1Co·S-1) in the Fischer-Tropsch synthesis reaction.     

Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-l-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78 % in BMS vs. 51.5 ± 12.20 % in AES vs. 34.7 ± 7.23 % in SES vs. 28.7 ± 7.30 % in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0–1.0) in BMS vs. 1.0 (range 1.0–1.0) in AES vs. 2.0 (range 2.0–2.0) in SES vs. 2.0 (range 2.0–2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88 % in BMS vs. 50.4 ± 14.87 % in AES vs. 34.5 ± 7.22 % in SES vs. 28.9 ± 7.22 % in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.     

Erratum to: Charge transfer in graphene/polymer interfaces for CO2 detection

Nano Research - The order of the authors in the original version of this article was unfortunately incorrect on the first page and the first page of the ESM. Instead of Myungwoo Son1, Yusin Pak1,...     

Highly Exposed ?NH2 Edge on Fragmented g-C3N4 Framework with Integrated Molybdenum Atoms for Catalytic CO2 Cycloaddition: DFT and Techno-Economic Assessment

This study focuses on the applicability of single-atom Mo-doped graphitic carbon nitride (GCN) nanosheets which are specifically engineered with high surface area (exfoliated GCN),  NH₂ rich edges, and maximum utilization of isolated atomic Mo for propylene carbonate (PC) production through CO₂ cycloaddition of propylene oxide (PO). Various operational parameters are optimized, for example, temperature (130 °C), pressure (20 bar), catalyst (Mo₂GCN), and catalyst mass (0.1 g). Under optimal conditions, 2% Mo-doped GCN (Mo₂GCN) has the highest catalytic performance, especially the turnover frequency (TOF) obtained, 36.4 h⁻¹ is higher than most reported studies. DFT simulations prove the catalytic performance of Mo₂GCN significantly decreases the activation energy barrier for PO ring-opening from 50–60 to 4.903 kcal mol⁻¹. Coexistence of Lewis acid/base group improves the CO₂ cycloaddition performance by the formation of coordination bond between electron-deficient Mo atom with O atom of PO, while  NH₂ surface group disrupts the stability of CO₂ bond by donating electrons into its low-level empty orbital. Steady-state process simulation of the industrial-scale consumes 4.4 ton h⁻¹ of CO₂ with PC production of 10.2 ton h⁻¹. Techno-economic assessment profit from Mo₂GCN is estimated to be 60.39 million USD year⁻¹ at a catalyst loss rate of 0.01 wt% h⁻¹.     

基于人工神经网络预测柴油机油台架试验结果

根据ＣＤ级柴油机的模拟实验与台架试验的基础数据,用人工神经网络的反向传播（ＢＰ）方法,对两者的关系进行了研究,给出了人工神经网络的学习速率为０．２,动量因子为０．９,对人工神经网络的拓扑结构也进行了研究,得到了合适的５－７－２拓扑结构及各节点间的权重系数。探讨了用模拟实验数据预测台架试验结果的可能性,通过检验,证明了用人工神经网络方法建立的模型能准确预报柴油机油的台架试验结果。     

基于AUTOSAR架构的通信系统的研究与实现

AUTOSAR是汽车开放系统体系结构,已成为汽车电子软件的工业标准,在汽车电子控制器系统开发过程中具有重要地位,其中AUTOSAR COM通信规范为汽车电子通信系统的构建提供了依据和参考;介绍了AUTOSAR体系架构,对AUTOSAR COM规范基于信号的通信机制及其特有的传输模式切换系统进行了研究,并实现了一种基于AUTOSAR架构的通信系统,试验结果表明该系统能够提供基本通信服务,且符合AUTOSAR COM规范。