基于．NET的药物临床试验网络信息服务平台的设计与实现

采用．NET平台与SQL-Server开发药物临床试验网络信息服务系统软件,代替传统的手工收集、处理、分析信息的工作模式,将药物临床试验项目管理的过程电子化、有效控制信息化,从而有效地控制、管理项目,达到其预期效果。     

定量构效关系研究中分子描述符的相关性

分子描述符的计算是定量构效关系(QSAR)研究的基础,也是化学计量学研究的重要内容,在药物化学、环境科学等领域应用广泛。目前可计算的各种分子描述符已超过4 000种,如何选择合适的分子描述符,成为QSAR研究中首先要做的事。本文首先综述了分子描述符的研究进展,然后随机选择10 000余个化合物,利用Cerius2、Sybyl、Dragon软件计算1 600多种分子描述符,最后,采用相关分析和聚类分析研究各描述符之间的关系,相关分析表明,各类分子描述符之间存在较强的线性关系,这种关系通过聚类分析可以直观体现。     

基于办公网络在线实验系统的实现

虚拟仪器技术的发展及应用,使远程实验办公成为可能。本文研究了基于办公网络的MatLab在线实验系统组建的多种技术方案,系统设计采用了Active X组件,COM组件等混合编程技术,服务器采用.NET框架、SQL数据库技术和网页制作技术,使先进的实验资源为办公网络中的所有用户所利用,满足办公环境下在线实验的需求。     

A preliminary attempt to use radiomic features in the diagnosis of extra-articular long head biceps tendinitis

Magnetic Resonance Materials in Physics, Biology and Medicine - This study aims to present a radiomic application in diagnosing the long head of biceps (LHB) tendinitis. Moreover, we evaluated...     

Multifunctional Organic Potassium Salt Additives as the Efficient Defect Passivator for High-Efficiency and Stable Perovskite Solar Cells

Despite the rapid developments are achieved for perovskite solar cells (PSCs), the existence of various defects in the devices still limits the further enhancement of the power conversion efficiency (PCE) and the long-term stability of devices. Herein, the efficient organic potassium salt (OPS) of para-halogenated phenyl trifluoroborates is presented as the precursor additives to improve the performance of PSCs. Studies have shown that the 4-chlorophenyltrifluoroborate potassium salt (4-ClPTFBK) exhibits the most effective interaction with the perovskite lattice. Strong coordination between  BF₃⁻/halogen in anion and uncoordinated Pb²⁺/halide vacancies, along with the hydrogen bond between F in  BF₃⁻ and H in FA⁺ are observed. Thus, due to the synergistic contribution of the potassium and anionic groups, the high-quality perovskite film with large grain size and low defect density is achieved. As a result, the optimal devices show an enhanced efficiency of 24.50%, much higher than that of the control device (22.63%). Furthermore, the unencapsulated devices present remarkable thermal and long-term stability, maintaining 86% of the initial PCE after thermal test at 80 °C for 1000 h and 95% after storage in the air for 2460 h.     

Using attention LSGB network for facial expression recognition

Pattern Analysis and Applications - Both the multiple sources of the available in-the-wild datasets and noisy information of images lead to huge challenges for discriminating subtle distinctions...     

基于Roberts边缘检测的数字媒体激光重现方法

为提高三维激光重现技术在特定光照条件下角分辨率的精度,研究基于Roberts边缘检测的数字媒体激光重现方法。搭建三维信息主动获取结构,分析编码光条纹偏移的关系,并根据条纹编码设计二进制码字的排列分布,完成结构光的编码和解码;提取边缘特征,引入Roberts边缘检测算子,检测对角方向上两个相邻像素差,分析尺度空间中检测点的分布,采用检测器提高稳定性,生成特征点描述子,完成数字媒体三维激光重现。实验结果显示,设计的技术具有更高的角分辨率精度,在92%以上,平均成像误差为1.24像素,成像时间为3 s。     

Face anti-spoofing based on multi-modal and multi-scale features fusion

Face anti-spoofing is used to assist face recognition system to judge whether the detected face is real face or fake face. In the traditional face anti-spoofing methods, features extracted by hand are used to describe the difference between living face and fraudulent face. But these handmade features do not apply to different variations in an unconstrained environment. The convolutional neural network (CNN) for face deceptions achieves considerable results. However, most existing neural network-based methods simply use neural networks to extract single-scale features from single-modal data, while ignoring multi-scale and multi-modal information. To address this problem, a novel face anti-spoofing method based on multi-modal and multi-scale features fusion ( MMFF) is proposed. Specifically, first residual network ( Resnet )-34 is adopted to extract features of different scales from each modality, then these features of different scales are fused by feature pyramid network (FPN), finally squeeze-and-excitation fusion ( SEF) module and self-attention network ( SAN) are combined to fuse features from different modalities for classification. Experiments on the CASIA-SURF dataset show that the new method based on MMFF achieves better performance compared with most existing methods.     

Polypyrrole Whelk‐Like Arrays toward Robust Controlling Manipulation of Organic Droplets Underwater

Whelk‐like polypyrrole (PPy) arrays film is successfully prepared by electropolymerization of pyrrole in the presence of low‐surface‐energy tetraethylammonium perfluorooctanesulfonate (TEAPFOS) as dopant. The underwater wettability of PPy whelk‐like arrays can be successfully tuned by electrical doping/dedoping of PFOS ions. Interestingly, CCl₄ droplets with microliter‐size as a representative sample are gathered together to form a larger droplet underwater at the potential of +0.8 V (vs Ag/AgCl), because PPy is in its PFOS‐doped states. Note that CCl₄ droplet can climb uphill successfully on the inclined whelk‐like arrays PPy film under the applied potential of ?1.0 V (vs Ag/AgCl), which may be attributed to wettability gradient derived from different oxidation states of PPy induced by electrochemical potential. These results may provide a simple strategy for on‐demand manipulation of organic droplets underwater at low voltage.