On the existence of chaos in the electronically adjustable structures of the state variable filters

As demonstrated in the paper, chaotic motion can appear in state variable filters, that is, common network structures dedicated for analog signal processing. In particular, two Kerwin–Huelsman–Newcomb biquadratic filtering sections are considered for theoretical, numerical and experimental analysis. Mathematical models are designed, and conditions for evolution of typical strange attractors are provided. The corresponding largest Lyapunov exponent is calculated and visualized as a function of internal system parameters and the shape of input harmonic waveform. Mutual connection between the mathematical model and the real lumped electronic circuit is discussed in detail. Copyright © 2016 John Wiley & Sons, Ltd.     

Variable narrowband transmission filters with a wide rejection band for spectrometry

Variable narrowband transmission filters are useful for the development of compact spectrometers. For this purpose the filter should be directly coupled to the detector and the wavelength of the transmission peak should move in one surface direction over a length of a few millimeters. To obtain both a wide measurement spectrum and high accuracy, the ratio of extreme operating wavelengths is required to be greater than 2:1 and the width of the transmission band narrower than 10 nm. A metal-dielectric variable transmission filter, with an operating range of 400-1000 nm, is proposed. The method for obtaining variable transmission filters, with dimensions of a few millimeters, is described.     

Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance

BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the BRCA1 gene causing inferior survival of breast cancer patients. Most studies have focused on the analysis of complete loss or mutations in functional domains of BRCA1. How mutations in non-functional domains contribute to resistance mechanisms remains elusive and was the focus of this study. Therefore, clones of the breast cancer cell line MCF7 with indels in BRCA1 exon 9 and 14 were generated using CRISPR/Cas9. Clones with successful introduced BRCA1 mutations were evaluated regarding their capacity to perform HR, how they handle DNA replication stress (RS), and the consequences on the sensitivity to MMC, PARP1 inhibition, and ionizing radiation. Unexpectedly, BRCA1 mutations resulted in both increased sensitivity and resistance to exogenous DNA damage, despite a reduction of HR capacity in all clones. Resistance was associated with improved DNA double-strand break repair and reduction in replication stress (RS). Lower RS was accompanied by increased activation and interaction of proteins essential for the S phase-specific DNA damage response consisting of HR proteins, FANCD2, and CHK1.     

Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions

A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this study, we investigated structural and numerical chromosomal aberrations in adenomas, hypothesizing that chromosomal instability (CIN) occurs early in adenomas. We applied array comparative genomic hybridization (aCGH) to fresh frozen colorectal adenomas and their adjacent mucosa from 16 patients who underwent colonoscopy examination. In our study, histologically similar colorectal adenomas showed wide variability in chromosomal instability. Based on the obtained results, we further stratified patients into four distinct groups. The first group showed the gain of MALAT1 and TALAM1, long non-coding RNAs (lncRNAs). The second group involved patients with numerous microdeletions. The third group consisted of patients with a disrupted karyotype. The fourth group of patients did not show any CIN in adenomas. Overall, we identified frequent losses in genes, such as TSC2, COL1A1, NOTCH1, MIR4673, and GNAS, and gene gain containing MALAT1 and TALAM1. Since long non-coding RNA MALAT1 is associated with cancer cell metastasis and migration, its gene amplification represents an important event for adenoma development.     

Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist

Transient receptor potential vanilloid 1 (TRPV1) channels contribute to the development of several chronic pain states and represent a possible therapeutic target in many painful disease treatment. Proinflammatory mediator bradykinin (BK) sensitizes TRPV1, whereas noxious peripheral stimulation increases BK level in the spinal cord. Here, we investigated the involvement of spinal TRPV1 in thermal and mechanical hypersensitivity, evoked by intrathecal (i.t.) administration of BK and an endogenous agonist of TRPV1, N-oleoyldopamine (OLDA), using behavioral tests and i.t. catheter implantation, and administration of BK-induced transient thermal and mechanical hyperalgesia and mechanical allodynia. All these hypersensitive states were enhanced by co-administration of a low dose of OLDA (0.42 µg i.t.), which was ineffective only under the control conditions. Intrathecal pretreatment with TRPV1 selective antagonist SB366791 prevented hypersensitivity induced by i.t. co-administration of BK and OLDA. Our results demonstrate that both thermal and mechanical hypersensitivity evoked by co-administration of BK and OLDA is mediated by the activation of spinal TRPV1 channels.     

Performance analysis of LoRa in the 2.4 GHz ISM band: coexistence issues with Wi-Fi

Telecommunication Systems - Within realization of the visions of the Internet-of-Things (IoT), Low Power Wide Area Networks (LPWANs) are undoubtedly one of the fields that attract high interest...     

Activity of ruthenium hydrogenation catalysts in copper(II) formate decomposition

Charcoal-, silica-, alumina- and titanium(IV) oxide-supported ruthenium catalysts, prepared by conventional impregnation and incipient wetness methods from a ruthenium(III) oxide precursor were tested in copper(II) formate decomposition in aqueous solution. Such a reaction was found to be an efficient and simple activity test of charcoal-supported catalysts. The application of this reaction for a bimetallic ruthenium–copper catalyst preparation was also suggested. Experimental results were compared with those obtained using commercial catalysts and ruthenium black.     

Utility of silver‐coated fabrics as electrodes in electrotherapy applications

The present study deals with the deposition of silver particles onto knitted fabrics for possible applications in electrotherapy. The performance of silver‐coated fabrics was evaluated based on number of properties such as electrical conductivity, physiological comfort, antibacterial, and durability. Furthermore, the conductive fabrics were subjected to various repeated extensions and change in electrical resistivity was examined to simulate the performance of electrodes under various movements of human body. With increase in extension till 80%, very small change in volume electrical resistance was observed and after 90% extension, the electrical resistance was found to increase significantly. The volume resistance was found to remain constant for repeated extensions of over 100 cycles and also there was insignificant change in electrical resistivity when constant current was applied over prolonged time. The utility of silver‐coated fabrics can be expected as flexible textile electrodes in transcutaneous electrical nerve stimulation electrotherapy applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46357.