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91.
Meghan Allen Rock Leung Joanna McGrenere Barbara Purves 《Universal Access in the Information Society》2008,7(3):145-154
Teams engaging in assistive technology research should include expertise in the domain of disability itself, in addition to
other areas of expertise that are more typical in human–computer interaction (HCI) research, such as computer science and
psychology. However, unexpected problems can arise when HCI researchers do not adequately plan the involvement of domain experts
in a research project. Although many research teams have included domain experts when designing assistive technologies, there
has been little work published on how to best involve these experts in the research process. This paper is a first step towards
filling that void. Based on the authors’ own experiences involving domain experts in research, as well as those documented
in the literature, five types of domain experts and three broad roles that domain experts can play are identified, and five
guidelines for their involvement are presented. This analysis will be useful to anyone in the assistive technology and universal
accessibility communities, especially those who are in the early stages of conducting research in this area. It is intended
to lay the foundation of best practices for involving domain experts in assistive technology research. 相似文献
92.
Lia Stanciu Dat Quach Christopher Faconti Joanna R. Groza Friedrich Raether 《Journal of the American Ceramic Society》2007,90(9):2716-2722
The behavior of nanostructured and submicrometer α-Al2 O3 powders during the initial stages of field-assisted sintering technique (FAST), conventional, and microwave sintering was investigated using the laser-flash technique for thermo-optical measurements (TOM). An enhanced neck formation due to surface diffusion at very early stages of sintering was found in FAST samples. No significant difference due to heating rate has been found in these various samples. 相似文献
93.
Magnetic resonance studies of cement based materials in inhomogeneous magnetic fields 总被引:1,自引:0,他引:1
Joanna Boguszynska Peter J. McDonald Jonathan Mitchell Jadwiga Tritt-Goc 《Cement and Concrete Research》2005,35(10):2033-2040
Single-sided magnets give hope that Nuclear Magnetic Resonance (NMR) might in future be used for in situ characterisation of hydration and water transport in the surface layers of concrete slabs. Towards that end, a portable NMR-MOUSE (MObile Universal Surface Explorer) has been used to follow the hydration of gypsum based plaster, a Portland cement paste and concrete mortar. The results compare favourably to those obtained using a standard laboratory bench-top spectrometer. Further, stray field imaging (STRAFI) based methods have been used with embedded NMR detector coils to study water transport across a mortar/topping interface. The measured signal amplitudes are found to correlate with varying sample conditions. 相似文献
94.
Jrmy Lamarche Luisa Ronga Joanna Szpunar Ryszard Lobinski 《International journal of molecular sciences》2021,22(12)
Selenoprotein P (SELENOP) is an emerging marker of the nutritional status of selenium and of various diseases, however, its chemical characteristics still need to be investigated and methods for its accurate quantitation improved. SELENOP is unique among selenoproteins, as it contains multiple genetically encoded SeCys residues, whereas all the other characterized selenoproteins contain just one. SELENOP occurs in the form of multiple isoforms, truncated species and post-translationally modified variants which are relatively poorly characterized. The accurate quantification of SELENOP is contingent on the availability of specific primary standards and reference methods. Before recombinant SELENOP becomes available to be used as a primary standard, careful investigation of the characteristics of the SELENOP measured by electrospray MS and strict control of the recoveries at the various steps of the analytical procedures are strongly recommended. This review critically discusses the state-of-the-art of analytical approaches to the characterization and quantification of SELENOP. While immunoassays remain the standard for the determination of human and animal health status, because of their speed and simplicity, mass spectrometry techniques offer many attractive and complementary features that are highlighted and critically evaluated. 相似文献
95.
The structural mobility of monomeric units of molecular bottle-brushes was studied by a systematic evaluation of NMR relaxation dynamics. The spin-spin relaxation time (T2) was determined by Carr-Purcell-Meiboom-Gill (CPMG) NMR spectroscopic measurements. T2 for protons that reside on the exterior and interior of the bottle-brush macromolecules varied with the grafting density and side chain length in bottle-brush copolymers. Poly((2-(2-bromopropionyloxy)ethyl methacrylate-stat-methyl methacrylate)-graft-butyl acrylate) (poly((BPEM-stat-MMA)-graft-PBA) was studied as a model brush copolymer. The T2 values for protons of MMA units in the brush backbone significantly decreased with increasing side chain length and grafting density of PBA. The mobility and relaxation times T2 for the side chain PBA protons decreased with grafting density. However, after initial increase, the relaxation times eventually decreased with PBA side chain length. 相似文献
96.
Ghada Ziadeh Sossy Shadarevian Amal Malek Joanna Khalil Tharwat Haddad John Haddad Imad Toufeili 《Journal of food science》2005,70(8):s548-s552
Pita bread loaves were prepared from flours fortified with calcium carbonate, calcium sulfate, and tricalcium dicitrate at 8 ascending levels to provide ranges of 800 to 2500, 700 to 1500, and 400 to 2000 mg of added Ca/100 g flour, respectively. The detection thresholds of calcium salts in pita bread were determined by the 3‐alter‐native forced choice (3‐AFC) test and construction of dose‐response curves. Detection thresholds determined by calculating geometric mean of individual best estimate thresholds, using criterion of 50%‐above‐chance and probit analysis of 3‐AFC data, were in the middle region of calcium concentrations. Analysis of dose‐response curves yielded values for thresholds outside the range of surveyed calcium concentrations. The detection threshold of CaSO4 (2724 mg/100 g) in pita bread was significantly higher (P < 0.01) than those of calcium carbonate (1984 mg/100 g) and tricalcium dicitrate (2132 mg/100 g). Calcium‐fortified pita bread was similar (P < 0.01) to its regular counterpart when formulated to contain 1254.6, 1772.5, or 1155 mg/100 g of CaCO3, CaSO4, or tricalcium dicitrate, respectively. At the indicated levels of fortification, calcium‐fortified pita bread is expected to provide between 61% and 126.5% of the recommended daily intake for calcium for Middle Eastern populations. 相似文献
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100.
Joanna Janisiak Patrycja Kopytko Marta Tkacz Dorota Rogiska Magdalena Peruyska Bogusaw Machaliski Andrzej Pawlik Maciej Tarnowski 《International journal of molecular sciences》2021,22(15)
Rhabdomyosarcoma (RMS) is a malignant soft tissue cancer that develops mostly in children and young adults. With regard to histopathology, four rhabdomyosarcoma types are distinguishable: embryonal, alveolar, pleomorphic and spindle/sclerosing. Currently, increased amounts of evidence indicate that not only gene mutations, but also epigenetic modifications may be involved in the development of RMS. Epigenomic changes regulate the chromatin architecture and affect the interaction between DNA strands, histones and chromatin binding proteins, thus, are able to control gene expression. The main aim of the study was to assess the role of protein arginine methyltransferases (PRMT) in the cellular biology of rhabdomyosarcoma. In the study we used two pan-inhibitors of PRMT, called AMI-1 and SAH, and evaluated their effects on proliferation and apoptosis of RMS cells. We observed that AMI-1 and SAH reduce the invasive phenotype of rhabdomyosarcoma cells by decreasing their proliferation rate, cell viability and ability to form cell colonies. In addition, microarray analysis revealed that these inhibitors attenuate the activity of the PI3K-Akt signaling pathway and affect expression of genes related to it. 相似文献