Hyperphagia modifies FA profiles of plasma phospholipids,plasma FFA,and adipose tissue TAG

Hyperphagia was achieved by continuous intracerebroventricular infusion of a melanocortin receptor antagonist (HS024; Neosystem, Strasbourg, France) in rats. The effects of hyperphagia on FA composition and concentration of plasma phospholipids (PL), plasma FFA, and adipose tissue TAG were studied in rats for 8 d [short-term hyperphagia (STH); n=8], or 28 d [longterm hyperphagia (LTH); n=9]. The control rats were treated with artificial cerebrospinal fluid for 8 d (n=8) or 28 d (n=10). The rats were fed the same regular diet. In STH rats the plasma PL and fasting plasma FFA contained higher concentrations of saturated FA (SFA) and monounsaturated FA (MUFA), and plasma FFA contained lower n−6 PUFA than in the control rats. In LTH rats the plasma PL contained higher concentrations of SFA, MUFA, and n−3 PUFA and higher proportions of 16∶1n−7 and 18∶1n−9 at the expense of 18∶2n−6 than in the control rats. In LTH rats the abundant dietary intake of 18∶2n−6 did not enrich 18∶2n−6 of the plasma PL or adipose tissue TAG. In LTH rats the fasting plasma FFA contained more than twofold higher concentrations of SFA and MUFA, and higher proportions of 16∶1n−7 and 18∶1n−9 at the expense of 18∶2n−6 than in the control rats. This animal obesity model shows that LTH affects the FA composition and concentration of plasma PL, plasma FFA, and adipose tissue TAG, a result consistent with changes associated with increased risk of various diseases in humans. These results also demonstrate that LTH alters the FA composition of plasma PL and adipose tissue TAG in a way that does not reflect the FA composition of dietary fat.     

一种新颖的双桥矩阵变换器控制策略

矩阵变换器是一种AC/AC变换器,它具有正弦输入电流、正弦输出电压、能量双向流动及体积小的优点,但存在着控制方法复杂,开关器件和保护元器件太多的问题.近年来提出的双桥矩阵变换器具有矩阵变换器的优点,同时其控制方法更简单,所用开关元件数目更少.论述了双桥矩阵变换器的原理,讨论了变换器的PWM控制策略以及基于线电压符号的换流方法,提出了整流级、逆变级单独控制,整流级开关频率为10kHz、逆变级开关频率为2kHz的新颖双桥矩阵变换器方案,给出了仿真和实验结果.     

QoS Performance Bounds and Efficient Connection Admission Control for Heterogeneous Services in Wireless Cellular Networks

Quality-of-Service (QoS) performance and connection admission control (CAC) for heterogeneous services in wireless multiple access networks are investigated. The heterogeneous services include constant bit rate (CBR), variable bit rate (VBR) and available bit rate (ABR) services. Multiple access control is handled by a polling-based scheme with non-preemptive priority. Tight delay variation (jitter) bounds for CBR connections and delay bounds for VBR connections are derived. A CAC scheme based on the derived bounds is developed. The CAC makes use of user mobility information to reserve an appropriate amount of system resources for potential handoff connections to achieve low handoff connection dropping rate (HCDR). Simulation results show that the proposed CAC scheme can achieve both low HCDR and high resource utilization.     

Intelligent Handoff for Mobile Wireless Internet

This paper presents an intelligent mobility management scheme for Mobile Wireless InterNet – MWIN. MWIN is a wireless service networks wherein its core network consisting of Internet routers and its access network can be built from any Internet-capable radio network. Two major standards are currently available for MWIN, i.e., the mobile IP and wireless LAN. Mobile IP solves address mobility problem with the Internet protocol while wireless LAN provides a wireless Internet access in the local area. However, both schemes solve problems independently at different layers, thereby some additional problems occur, e.g., delayed handoff, packet loss, and inefficient routing. This paper identifies these new problems and performs analyses and some real measurements on the handoff within MWIN. Then, a new handoff architecture that extends the features of both mobile IP and wireless LAN handoff mechanism was proposed. This new architecture consists of mobile IP extensions and a modified wireless LAN handoff algorithm. The effect of this enhancement provides a linkage between different layers for preventing packet loss and reducing handoff latency. Finally, some optimization issues regarding network planning and routing are addressed.     

Habitat fragmentation has interactive effects on the population genetic diversity and individual behaviour of a freshwater salmonid fish

Sufficient genetic diversity can aid populations to persist in dynamic and fragmented environments. Understanding which mechanisms regulate genetic diversity of riverine fish can therefore advance current conservation strategies. The aim of this study was to investigate how habitat fragmentation interacted with population genetic diversity and individual behaviour of freshwater fish in large river systems. We studied a population of the long‐distance migratory, iteroparous freshwater salmonid European grayling (Thymallus thymallus) in south‐eastern Norway. Genotyping (n = 527) and radio‐tracking (n = 54) of adult fish throughout a 169‐km river section revealed three major migration barriers limiting gene flow and depleting genetic diversity upstream. Individuals from upstream areas that had dispersed downstream of barriers showed different movement behaviour than local genotypes. No natal philopatry was found in a large unfragmented river section, in contrast to strong fidelity to spawning tributaries known for individuals overwintering in lakes. We conclude that (a) upstream sub‐populations in fragmented rivers show less genetic variation, making it less likely for them to adapt to environmental changes; (b) fish with distinct genotypes in the same habitat can differ in their behaviour; (c) spawning site selection (natal philopatry) can differ between fish of the same species living in different habitats. Together this implies that habitat loss and fragmentation may differently affect individual fish of the same species if they live in different types or sections of habitat. Studying behaviour and genetic diversity of fish can unravel their complex ecology and help minimize human impact.     

Phage‐mediated transfer of virulence genes

Bacteriophages as accessory genetic elements play a crucial role in the dissemination of genes and the promotion of genetic diversity within bacterial populations. Such horizontal transfer of DNA is critical in the emergence of new pathogenic organisms, through the dissemination of genes encoding virulence factors such as toxins, adhesins and agressins. Phages can transfer genes that are not necessary for bacteriophage persistence and are generally recognised by their ability to convert their host bacteria to new phenotypes. This phenomenon is known as phage conversion. If such converting genes encode for virulence factors, the consequences of phage infection may include increased virulence of the host bacteria, and the conversion of a non‐pathogenic strain to a potentially dangerous pathogen. A number of virulence factors in bacteria causing diseases in plants, animals and humans are encoded by converting phages, the vast majority of which are temperate as opposed to lytic in nature. © 2001 Society of Chemical Industry