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51.
An EKV-based high voltage MOSFET model is presented. The intrinsic channel model is derived based on the charge based EKV-formalism. An improved mobility model is used for the modeling of the intrinsic channel to improve the DC characteristics. The model uses second order dependence on the gate bias and an extra parameter for the smoothening of the saturation voltage of the intrinsic drain. An improved drift model [Chauhan YS, Anghel C, Krummenacher F, Ionescu AM, Declercq M, Gillon R, et al. A highly scalable high voltage MOSFET model. In: IEEE European solid-state device research conference (ESSDERC), September 2006. p. 270–3; Chauhan YS, Anghel C, Krummenacher F, Maier C, Gillon R, Bakeroot B, et al. Scalable general high voltage MOSFET model including quasi-saturation and self-heating effect. Solid State Electron 2006;50(11–12):1801–13] is used for the modeling of the drift region, which gives smoother transition on output characteristics and also models well the quasi-saturation region of high voltage MOSFETs. First, the model is validated on the numerical device simulation of the VDMOS transistor and then, on the measured characteristics of the SOI-LDMOS transistor. The accuracy of the model is better than our previous model [Chauhan YS, Anghel C, Krummenacher F, Maier C, Gillon R, Bakeroot B, et al. Scalable general high voltage MOSFET model including quasi-saturation and self-heating effect. Solid State Electron 2006;50(11–12):1801–13] especially in the quasi-saturation region of output characteristics.  相似文献   
52.
Free radical-mediated esophagitis was studied during duodenogastroesophageal reflux (mixed reflux) or acid reflux in rats. The influence of reflux on esophageal glutathione levels was also examined. Mixed reflux caused more gross mucosal injury than acid reflux. Gross mucosal injury occurred in the mid-esophagus. Total glutathione (GSH) in the esophageal mucosa of control rats was highest in the distal esophagus. The time course of esophageal GSH in rats treated by mixed reflux showed a significant decrease 4 hr after initiation of reflux, followed by a significant increase from the 12th hour on. Mucosal GSH was increased in both reflux groups after 24 hr but significantly more so in the mixed than in the acid reflux group. The free radical scavenger superoxide dismutase (SOD) prevented esophagitis and was associated with decreased GSH levels. GSH depletion by buthionine sulfoximine (BSO) prevented esophagitis and stimulated SOD production in the esophageal mucosa. It is concluded that gastroesophageal reflux is associated with oxidative stress in the esophageal mucosa. The lower GSH levels in the mid-esophagus may predispose to damage in this area. Duodenogastroesophageal reflux causes more damage than pure acid reflux. Oxidative stress leads to GSH depletion of the esophageal mucosa in the first few hours following damage but then stimulates GSH production. GSH depletion by BSO does not worsen esophagitis since it increases the esophageal SOD concentration.  相似文献   
53.
We have identified and cloned a new member of the papain family of cysteine proteinases from a human brain cDNA library. The isolated cDNA codes for a polypeptide of 334 amino acids that exhibits all of the structural features characteristic of cysteine proteinases, including the active site cysteine residue essential for peptide hydrolysis. Pairwise comparisons of this amino acid sequence with the remaining human cysteine proteinases identified to date showed a high percentage of identity (78%) with cathepsin L; the percentage of identity with all other members of the family was much lower (<40%). On the basis of these structural characteristics, we have tentatively called this novel protein cathepsin L2. The cDNA encoding the mature cathepsin L2 was expressed in Escherichia coli, and after purification, the recombinant protein was able to degrade the synthetic peptide benzyloxycarbonyl-L-phenylalanyl-L-arginine-7-amido-4-methylcoumarin, which is commonly used as a substrate for cysteine proteinases. Cathepsin L2 proteolytic activity on this substrate was abolished by trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane, an inhibitor of cysteine proteinases, thus providing additional evidence that the isolated cDNA encodes a functional cysteine proteinase. Northern blot analysis of polyadenylated RNAs isolated from a variety of human tissues demonstrated that cathepsin L2 is predominantly expressed in the thymus and testis. This finding is in marked contrast with the wide tissue distribution of most cysteine proteinases characterized to date, including cathepsin L, and suggests that cathepsin L2 may play a specialized role in the thymus and testis. Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas. These results open the possibility that this novel enzyme may be involved in tumor processes, as already reported for other cysteine proteinases, including cathepsin L.  相似文献   
54.
Shift work situations occur in almost all safety‐critical organizations, and the investigations of some catastrophes like Chernobyl, Exxon Valdez, and the Gol/Legacy mid‐air collision indicated that shift work information exchange played an important role during the evolution of the situation before the accidents. Inadequate communications during shift changeovers challenged operators' work in the moments that preceded these accidents, because they got inadequate information about the current situation. Our research focuses on the information exchange activities (verbal, written, and nonverbal) of nuclear power plant control operators during shift changeovers. Our aim is to investigate how verbal exchanges and other representations enable operator crews to share information regarding the events that occurred in the previous shift to achieve adequate situation awareness. Our findings indicated the importance and richness of the information exchange during the shift changeover process to update and validate individual and collective situation awareness, showing that information adequately shared enables the ad hoc configurations of regulation loops and a safer use of simplified strategies that can be understood and be validated by other operators, reducing the occurrence of cognitive overloads and contributing to the construction of a common cognitive ground that enhances system resilience. © 2010 Wiley Periodicals, Inc.  相似文献   
55.
Intelligent air traffic flow management is one of the fundamental challenges facing the Federal Aviation Administration (FAA) today. FAA estimates put weather, routing decisions and airport condition induced delays at 1,682,700 h in 2007 (FAA OPSNET Data, US Department of Transportation website, ), resulting in a staggering economic loss of over $41 billion (Joint Economic Commission Majority Staff, Your flight has been delayed again, 2008). New solutions to the flow management are needed to accommodate the threefold increase in air traffic anticipated over the next two decades. Indeed, this is a complex problem where the interactions of changing conditions (e.g., weather), conflicting priorities (e.g., different airlines), limited resources (e.g., air traffic controllers) and heavy volume (e.g., over 40,000 flights over the US airspace) demand an adaptive and robust solution. In this paper we explore a multiagent algorithm where agents use reinforcement learning (RL) to reduce congestion through local actions. Each agent is associated with a fix (a specific location in 2D space) and has one of three actions: setting separation between airplanes, ordering ground delays or performing reroutes. We simulate air traffic using FACET which is an air traffic flow simulator developed at NASA and used extensively by the FAA and industry. Our FACET simulations on both artificial and real historical data from the Chicago and New York airspaces show that agents receiving personalized rewards reduce congestion by up to 80% over agents receiving a global reward and by up to 90% over a current industry approach (Monte Carlo estimation).  相似文献   
56.
This work is part of a project aimed to develop automotive real-time observers based on detailed nonlinear multibody models and the extended Kalman filter (EKF). In previous works, a four-bar mechanism was studied to get insight into the problem. Regarding the formulation of the equations of motion, it was concluded that the state-space reduction method known as matrix-R is the most suitable one for this application. Regarding the sensors, it was shown that better stability, accuracy and efficiency are obtained as the sensored magnitude is a lower derivative and when it is a generalized coordinate of the problem. In the present work, the automotive problem has been addressed, through the selection of a Volkswagen Passat as a case-study. A model of the car containing fifteen degrees of freedom has been developed. The observer algorithm that combines the equations of motion and the integrator has been reformulated so that duplication of the problem size is avoided, in order to improve efficiency. A maneuver of acceleration from rest and double lane change has been defined, and tests have been run for the “prototype,” the “model” and the “observer,” all the three computational, with the model having 100 kg more than the prototype. Results have shown that good convergence is obtained for position level sensors, but the computational cost is high, still far from real-time performance.  相似文献   
57.
This work presents a study of RTP multiplexing schemes, which are compared with the normal use of RTP, in terms of experienced quality. Bandwidth saving, latency and packet loss for different options are studied, and some tests of Voice over IP (VoIP) traffic are carried out in order to compare the quality obtained using different implementations of the router buffer. Voice quality is calculated using ITU R-factor, which is a widely accepted quality estimator. The tests show the bandwidth savings of multiplexing, and also the importance of packet size for certain buffers, as latency and packet loss may be affected. The customer’s experience improvement is measured, showing that the use of multiplexing can be interesting in some scenarios, like an enterprise with different offices connected via the Internet. The system is also tested using different numbers of samples per packet, and the distribution of the flows into different tunnels is found to be an important factor in order to achieve an optimal perceived quality for each kind of buffer. Grouping all the flows into a single tunnel will not always be the best solution, as the increase of the number of flows does not improve bandwidth efficiency indefinitely. If the buffer penalizes big packets, it will be better to group the flows into a number of tunnels. The router processing capacity has to be taken into account too, as the limit of packets per second it can manage must not be exceeded. The obtained results show that multiplexing is a good way to improve customer’s experience of VoIP in scenarios where many RTP flows share the same path.  相似文献   
58.
We present three new approximation algorithms with improved constant ratios for selecting n points in n disks such that the minimum pairwise distance among the points is maximized.
  1. A very simple O(nlog?n)-time algorithm with ratio 0.511 for disjoint unit disks.
  2. An LP-based algorithm with ratio 0.707 for disjoint disks of arbitrary radii that uses a linear number of variables and constraints, and runs in polynomial time.
  3. A hybrid algorithm with ratio either 0.4487 or 0.4674 for (not necessarily disjoint) unit disks that uses an algorithm of Cabello in combination with either the simple O(nlog?n)-time algorithm or the LP-based algorithm.
The LP algorithm can be extended for disjoint balls of arbitrary radii in ? d , for any (fixed) dimension d, while preserving the features of the planar algorithm. The algorithm introduces a novel technique which combines linear programming and projections for approximating Euclidean distances. The previous best approximation ratio for dispersion in disjoint disks, even when all disks have the same radius, was 1/2. Our results give a positive answer to an open question raised by Cabello, who asked whether the ratio 1/2 could be improved.  相似文献   
59.
Radial Basis Function Neural Networks (RBFNNs) have been successfully employed in several function approximation and pattern recognition problems. The use of different RBFs in RBFNN has been reported in the literature and here the study centres on the use of the Generalized Radial Basis Function Neural Networks (GRBFNNs). An interesting property of the GRBF is that it can continuously and smoothly reproduce different RBFs by changing a real parameter τ. In addition, the mixed use of different RBF shapes in only one RBFNN is allowed. Generalized Radial Basis Function (GRBF) is based on Generalized Gaussian Distribution (GGD), which adds a shape parameter, τ, to standard Gaussian Distribution. Moreover, this paper describes a hybrid approach, Hybrid Algorithm (HA), which combines evolutionary and gradient-based learning methods to estimate the architecture, weights and node topology of GRBFNN classifiers. The feasibility and benefits of the approach are demonstrated by means of six gene microarray classification problems taken from bioinformatic and biomedical domains. Three filters were applied: Fast Correlation-Based Filter (FCBF), Best Incremental Ranked Subset (BIRS), and Best Agglomerative Ranked Subset (BARS); this was done in order to identify salient expression genes from among the thousands of genes in microarray data that can directly contribute to determining the class membership of each pattern. After different gene subsets were obtained, the proposed methodology was performed using the selected gene subsets as new input variables. The results confirm that the GRBFNN classifier leads to a promising improvement in accuracy.  相似文献   
60.
A novel mesh-free approach for solving differential equations based on Evolution Strategies (ESs) is presented. Any structure is assumed in the equations making the process general and suitable for linear and nonlinear ordinary and partial differential equations (ODEs and PDEs), as well as systems of ordinary differential equations (SODEs). Candidate solutions are expressed as partial sums of Fourier series. Taking advantage of the decreasing absolute value of the harmonic coefficients with the harmonic order, several ES steps are performed. Harmonic coefficients are taken into account one by one starting with the lower order ones. Experimental results are reported on several problems extracted from the literature to illustrate the potential of the proposed approach. Two cases (an initial value problem and a boundary condition problem) have been solved using numerical methods and a quantitative comparative is performed. In terms of accuracy and storing requirements the proposed approach outperforms the numerical algorithm.  相似文献   
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