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991.
This paper presents a new approach to robustness analysis in multi-objective optimization problems aimed at obtaining the most robust Pareto front solutions and distributing the solutions along the most robust regions of the optimal Pareto set. A new set of test problems accounting for the different types of robustness cases is presented in this study. Non-dominated solutions are classified according to their degree of robustness and are distributed along the Pareto front according to specific algorithm parameter values. Verification of the proposed method is carried out using the developed test problems and artificial and real world benchmark test problems present in the literature.  相似文献   
992.
Intravascular clotting remains a major health problem in the United States, the most prominent being deep vein thrombosis, pulmonary embolism and thromboembolic stroke. Previous reports on the use of pyridine derivatives in cardiovascular drug development encourage us to pursue new types of compounds based on a pyridine scaffold. Eleven pyridine derivatives (oximes, semicarbazones, N-oxides) previously synthesized in our laboratories were tested as anticoagulants on pooled normal plasma using the prothrombin time (PT) protocol. The best anticoagulant within the oxime series was compound AF4, within the oxime N-oxide series was compound AF4-N-oxide, and within the semicarbazone series, compound MD1-30Y. We also used a molecular modeling approach to guide our efforts, and found that there was good correlation between coagulation data and computational energy scores. Molecular docking was performed to target the active site of thrombin with the DOCK v5.2 package. The results of molecular modeling indicate that improvement in anticoagulant activities can be expected by functionalization at the three-position of the pyridine ring and by N-oxide formation. Results reported here prove the suitability of DOCK in the lead optimization process.  相似文献   
993.
The point-feature cartographic label placement problem (PFCLP) is an NP-hard problem, which appears during the production of maps. The labels must be placed in predefined places avoiding overlaps and considering cartographic preferences. Owing to its high complexity, several heuristics have been presented searching for approximated solutions. This paper proposes a greedy randomized adaptive search procedure (GRASP) for the PFCLP that is based on its associated conflict graph. The computational results show that this metaheuristic is a good strategy for PFCLP, generating better solutions than all those reported in the literature in reasonable computational times.  相似文献   
994.
An important area of Human Reliability Assessment in interactive systems is the ability to understand the causes of human error and to model their occurrence. This paper investigates a new approach to analysis of task failures based on patterns of operator behaviour, in contrast with more traditional event-based approaches. It considers, as a case study, a formal model of an Air Traffic Control system operator’s task which incorporates a simple model of the high-level cognitive processes involved. The cognitive model is formalised in the CSP process algebra. Various patterns of behaviour that could lead to task failure are described using temporal logic. Then a model-checking technique is used to verify whether the set of selected behavioural patterns is sound and complete with respect to the definition of task failure. The decomposition is shown to be incomplete and a new behavioural pattern is identified, which appears to have been overlooked in the informal analysis of the problem. This illustrates how formal analysis of operator models can yield fresh insights into how failures may arise in interactive systems.
Antonio Cerone (Corresponding author)Email:
Simon ConnellyEmail:
Peter LindsayEmail:
  相似文献   
995.
Superpipelined high-performance optical-flow computation architecture   总被引:1,自引:0,他引:1  
Optical-flow computation is a well-known technique and there are important fields in which the application of this visual modality commands high interest. Nevertheless, most real-world applications require real-time processing, an issue which has only recently been addressed. Most real-time systems described to date use basic models which limit their applicability to generic tasks, especially when fast motion is presented or when subpixel motion resolution is required. Therefore, instead of implementing a complex optical-flow approach, we describe here a very high-frame-rate optical-flow processing system. Recent advances in image sensor technology make it possible nowadays to use high-frame-rate sensors to properly sample fast motion (i.e. as a low-motion scene), which makes a gradient-based approach one of the best options in terms of accuracy and consumption of resources for any real-time implementation. Taking advantage of the regular data flow of this kind of algorithm, our approach implements a novel superpipelined, fully parallelized architecture for optical-flow processing. The system is fully working and is organized into more than 70 pipeline stages, which achieve a data throughput of one pixel per clock cycle. This computing scheme is well suited to FPGA technology and VLSI implementation. The developed customized DSP architecture is capable of processing up to 170 frames per second at a resolution of 800 × 600 pixels. We discuss the advantages of high-frame-rate processing and justify the optical-flow model chosen for the implementation. We analyze this architecture, measure the system resource requirements using FPGA devices and finally evaluate the system’s performance and compare it with other approaches described in the literature.  相似文献   
996.
The Amazon rainforest is one of the world's greatest natural wonders and holds great importance and significance for the world's environmental balance. Around 60% of the Amazon rainforest is located in the Brazilian territory. The two biggest states of the Amazon region are Amazonas (the upper Amazon) and Pará (the lower Amazon), which together account for around 73% of the Brazilian Legal Amazon, and are the only states that are serviced by international airports in Brazil's north region. The purpose of this paper is to model and forecast sustainable international tourism demand for the states of Amazonas, Pará, and the aggregate of the two states. By sustainable tourism is meant a distinctive type of tourism that has relatively low environmental and cultural impacts. Economic progress brought about by illegal wood extraction and commercial agriculture has destroyed large areas of the Amazon rainforest. The sustainable tourism industry has the potential to contribute to the economic development of the Amazon region without destroying the rainforest. The paper presents unit root tests for monthly and annual data, estimates alternative time series models and conditional volatility models of the shocks to international tourist arrivals, and provides forecasts for 2006 and 2007.  相似文献   
997.
This paper presents a novel method for location recognition, which exploits an epitomic representation to achieve both high efficiency and good generalization. A generative model based on epitomic image analysis captures the appearance and geometric structure of an environment while allowing for variations due to motion, occlusions, and non-Lambertian effects. The ability to model translation and scale invariance together with the fusion of diverse visual features yields enhanced generalization with economical training. Experiments on both existing and new labeled image databases result in recognition accuracy superior to state of the art with real-time computational performance.  相似文献   
998.
Knowledge and Information Systems - The rapid increase of available data in different complex contexts needs automatic tasks to manage and process contents. Semantic Web technologies represent the...  相似文献   
999.
Electronic Commerce Research - This paper investigated the role of information related, social and customer characteristics in public information adoption tendencies of online customers to result...  相似文献   
1000.
Networks and Spatial Economics - We deal with the analysis of a general equilibrium model with restricted participation in financial markets and with numeraire assets. We consider an exchange...  相似文献   
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