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排序方式: 共有206条查询结果,搜索用时 15 毫秒
11.
Imola Wilhelm Judit Molnár Csilla Fazakas János Haskó István A. Krizbai 《International journal of molecular sciences》2013,14(1):1383-1411
The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate through the endothelial cell layer of brain capillaries, which forms the morphological basis of the blood-brain barrier (BBB). The BBB has a dual role in brain metastasis formation: it forms a tight barrier protecting the central nervous system from entering cancer cells, but it is also actively involved in protecting metastatic cells during extravasation and proliferation in the brain. The mechanisms of interaction of cancer cells and cerebral endothelial cells are largely uncharacterized. Here, we provide a comprehensive review on our current knowledge about the role of junctional and adhesion molecules, soluble factors, proteolytic enzymes and signaling pathways mediating the attachment of tumor cells to brain endothelial cells and the transendothelial migration of metastatic cells. Since brain metastases represent a great therapeutic challenge, it is indispensable to understand the mechanisms of the interaction of tumor cells with the BBB in order to find targets of prevention of brain metastasis formation. 相似文献
12.
Judit Olh Tibor Sznsi Attila Lehotzky Victor Norris Judit Ovdi 《International journal of molecular sciences》2022,23(3)
Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, however, the discovery of small molecules for use as drugs entails targeting individual proteins rather than targeting PPIs. This is largely because discovering small molecules to modulate PPIs has been seen as extremely challenging. Here, we review the difficulties and limitations of strategies to discover drugs that target PPIs directly or indirectly, taking as examples the disordered proteins involved in neurodegenerative diseases. 相似文献
13.
Josefina Pérez-Arantegui Judit Molera Angel Larrea Trinitat Pradell Marius Vendrell-Saz Ilaria Borgia Brunetto G. Brunetti Franco Cariati Paola Fermo Marcello Mellini Antonio Sgamellotti Cecilia Viti 《Journal of the American Ceramic Society》2001,84(2):442-46
Luster is a decorative metallic film that was applied on the surface of medieval glazed pottery. It can be obtained via the low-temperature (∼650°C), controlled reduction of copper and silver compounds. In this paper, we show that luster is a thin layered film (200–500 nm thick) that contains metallic spherical nanocrystals dispersed in a silicon-rich matrix and has a metal-free outermost glassy layer that is 10–20 nm thick. Silver nanocrystals seem to be separated from those of copper, forming aggregates 5–100 μm in diameter. This composite structure exhibits optical properties that are dependent on both the particle size and the matrix. Luster is indeed the first reproducible nanostructured thin metallic film that was made by humans. 相似文献
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The production of a lead glaze with galena: Thermal transformations in the PbS–SiO2 system 下载免费PDF全文
Roberta Di Febo Judit Molera Trinitat Pradell Joan C. Melgarejo Josep Madrenas Oriol Vallcorba 《Journal of the American Ceramic Society》2018,101(5):2119-2129
Galena, also known as PbS, was widely used in the production of lead glazes from the beginning of the 18th century to the second half of the 20th century. Although the PbO‐SiO2 system has been studied for years, the PbS–SiO2 phase diagram, involved in the formation of a glaze with galena, has not yet been investigated. Temperature transformations for the system 75 wt% PbS‐25 wt% SiO2 are investigated in a high‐temperature resolved X‐ray diffraction experiment with synchrotron radiation and compared to those of the equivalent system 70 wt% PbO‐30 wt% SiO2. Lanarkite, PbO·PbSO4, is the phase predominantly formed as soon as galena decomposes during the heating. The results show that the system melts at a temperature higher than the PbO–SiO2 system, but far lower than those expected for the PbO–PbSO4–PbS system. A historical misfired lead glaze produced with galena is also studied. The presence of galena, lanarkite, and mattheddleite, Pb10(SiO4)3.5(SO4)2Cl2, is determined and discussed in terms of the composition of the galena mineral used and the firing conditions in light of the high‐temperature transformations previously obtained. 相似文献
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C. Charles Chen Gabor Kaszas Judit E. Puskas Joseph P. Kennedy 《Polymer Bulletin》1989,22(5-6):463-470
Mono- and bifunctionaltert-alcohols, i.e., cumyl alcohol (CumOH), 2,4,4-trimethyl-2-pentanol (TMPOH), 2,6-dihydroxy-2,4, 4, 6-tetramethylheptane (TMHDiOH), in conjunction with BCl3 have been shown to be efficient initiating systems for the living polymerization of isobutylene (IB) in CH3Cl or CH2Cl2 solvents in the –10° to –80°C range. The living nature of the polymerizations was demonstrated by linear Mn versus amount of polyisobutylene (PIB) formed (WPIB) plots starting at the origin and corresponding horizontal number of PIB moles formed (N) versus WPIB plots. Quenching with methanol producestert-chlorine terminated PIBs. Quantitative dehydrochlorination of the latter products yields exo-olefin (isopropylidene) end groups. These experiments demonstrate that living carbocationic polymerizations have in fact been conducted in these laboratories long ago (1) without having been recognized as such. 相似文献
18.
Judit Molera Trinitat Pradell Nati Salvadó Marius Vendrell-Saz 《Journal of the American Ceramic Society》1999,82(10):2871-2875
Tin oxide (SnO2 ) particles that are a few hundred nanometers in size and are embedded in a lead glaze act as a white opacifier. The insolubility of SnO2 particles in a lead glaze is responsible for this microstructure. Although it is assumed that SnO2 particles do not react during the glaze formation, we demonstrate that the development of metastable phases prior to the fusion of the PbO-SiO2 -SnO2 mixture allows the SnO2 particles to react and then recrystallize subsequent to the fusion of the mixture. The recrystallization of SnO2 occurs during heating and/or cooling until the temperature is sufficiently low and/or the tin supply is exhausted. 相似文献
19.
Đurović Gordana Van Neerbos Francine A. C. Bossaert Sofie Herrera-Malaver Beatriz Steensels Jan Arnó Judit Wäckers Felix Sobhy Islam S. Verstrepen Kevin J. Jacquemyn Hans Lievens Bart 《Journal of chemical ecology》2021,47(8-9):788-798
Journal of Chemical Ecology - There is increasing evidence that microorganisms, particularly fungi and bacteria, emit volatile compounds that mediate the foraging behaviour of insects and therefore... 相似文献
20.
The World Wide Web is growing at an enormous speed, and has become an indispensable source for information and research. New
pages are constantly added, but there are additional processes as well: pages are moved or removed and/or their content changes.
We report here the results of an eight year long project started in 1998, when multiple search engines were used to identify
a set of pages containing the term informetrics. Data collection was repeated once a year for the last eight years (with the exception of 2000 and 2001) using both search
engines and revisiting previously identified pages. The results show that the number of pages grew from 866 in 1998 to 28,914
in 2006 — a 33-fold growth. Besides the obvious growth of the topic on the Web, we observed both decay (pages disappearing
from the Web) and modification. Even though most of the pages from 1998 either disappeared or ceased to contain the term informetrics, 165 pages (19.1%) still exist in 2006 and contain the search term. We followed the “fate” of these 165 pages: characterized
the publishers, the contents and the changes that occurred the whole period. In recent years e-print servers and publishers’
sites became sources of large number of pages related to informetrics. Longitudinal studies following the evolution of a topic on the Web are very important, since they provide insights about
content and the underlying Web processes. 相似文献