The anesthetic agent propofol (2,6-diisopropylphenol) is the most widely used intravenously administered drug in general anesthesia. However, a viable online capability to monitor metabolized levels of propofol in patients does not currently exist. Here we show for the first time that optical spectroscopy has good potential to detect metabolized propofol from patients' exhaled breath. We present quantitative absorption measurements of gas phase propofol both in the ultraviolet and middle-infrared spectral regions. We demonstrate that a detection limit in the subparts-per-billion concentration range can be reached with photoacoustic spectroscopy in the UV spectral region, paving the way for the development of future optical monitors. 相似文献
New municipal service buildings must be energy effective, and cost-optimality is one of the criteria for selecting the suitable energy performance improvement measures. A daycare building in a cold climate was studied by means of simulation-based, multi-objective optimisation. Using a genetic algorithm, both target energy use and life-cycle cost of the selected measures were minimised. It was found that extensive insulation of the building envelope is not a cost-optimal method to reduce the daycare building energy use. Improving energy efficiency of the ventilation system, utilising solar energy on-site and employing a light control strategy are preferable ways of improving the building energy performance. Ground-source heat pump is a more cost-optimal heating system for the daycare building than district heating. The cost-optimal sizing of the heat pump is small, only 28% of the required maximum heating power.
Abbreviations: AHU: air handling unit; CAV: constant air volume; COMBI: comprehensive development of nearly zero-energy municipal service buildings; COP: coefficient of performance; DH: district heating; DHW: domestic hot water; EPBD: energy performance of buildings directive; EU: European Union; FINVAC: Finnish Association of HVAC Societies; GSHP: ground-source heat pump; HRU: heat recovery unit; IDA ICE: IDA Indoor Climate and Energy; LED: light-emitting diode; MOBO: multi-objective building optimisation tool; NSGA-II: Non-dominated Sorting Genetic Algorithm II; nZEB: nearly zero-energy building; PV: photovoltaic; TRY: test reference year; VAV: variable air volume; ZEB: zero-energy building 相似文献
Energy and development are closely intertwined. Yet, increasing fossil fuel-based energy consumption contributes significantly to environmental problems both locally and globally. This article explores the interlinkages between local livelihood and environmental benefits from the provision of energy to remote rural households through small hydropower development. The analysis is based on research carried out around a large development project designed to assist the Government of India in the optimum utilization of small hydropower resources in the Himalayan and sub-Himalayan regions. There are about 100,000 villages in India that are not connected to electricity supply, many of them in the hilly regions with ample hydropower potential. The project aimed to demonstrate the utility of and options for providing electricity to such villages through clean mini-hydro. The article addresses the nature of the impacts of the demonstration small hydel schemes on the local communities, to what extent they translate into environmental benefits both locally and globally, and the perceptions and participation of the local communities in these small hydro schemes. The study explores the impacts of the schemes on financial capital, natural capital, social capital, physical capital, human capital, and gender equity in the local communities. It further provides a discussion on the links between local and global environmental benefits. Overall, it is found that the schemes’ impacts both on the local communities and the environment are mostly marginally positive or neutral, although achieving clearly demonstrable benefits would require major upscaling of the effort involving broader changes than possible under this project. Furthermore, it is argued that some of the assumptions behind the project design were faulty. Involvement of the local communities and direct livelihood benefits to them are essential for the long-term sustainability of the small hydro schemes. The discussion and conclusions are intended to provide guidance to programmes and projects that aim to promote environmentally sound energy in the rural areas of developing countries. 相似文献
A novel catalyst of cobalt supported by single crystal MgO was prepared by atomic layer deposition and used for carbon nanotube growth. With CO as carbon source, vertically-aligned carbon nanotubes with predominant double-walled (82%) were produced at 700 °C. Similar carbon nanotube array with a majority of single-walled tubes (62%) was produced at 900 °C using methane as the carbon source. Due to their high flexibility compared with multi-walled carbon nanotubes, the low-wall-number carbon nanotube array could form a 3-dimensional honeycomb-like network when being spread with acetone. 相似文献
This study presents measurements of the transport of quasiparticle excitations in the B phase of superfluid 3He at temperatures below 0.2Tc. We find that creating and then removing a layer of A-phase superfluid leads to a measurable increase in the thermal impedance of the background B phase. This increase must be due to the survival of defects created as the AB and BA interfaces on either side of the A-phase layer annihilate. We speculate that a new type of defect may have been formed. The highly ordered A-B interface may be a good analogy for branes discussed in current cosmology. If so, these experiments may provide insight into how the annihilation of branes can lead to the formation of topological defects such as cosmic strings. 相似文献
Protective coatings based on manganese cobalt oxide spinels are required in solid oxide fuel cells (SOFCs) to prevent the evaporation of volatile Cr(VI)-compounds from the metallic interconnectors and to minimize high temperature corrosion. Atmospheric plasma spraying (APS) was used to manufacture dense manganese cobalt oxide protective coatings on Crofer 22 APU substrates by employing two different spinel powders. The spray powders were MnCo2O4 and Mn2CoO4 + Co (equivalence for Mn1.5Co1.5O4). The Mn2CoO4 + Co powder was prepared by agglomerating the oxide powder with fine metallic cobalt powder. The coated substrates were oxidized at 700 °C in air for 1000 h. During the high temperature oxidation, a four-point on-line measurement technique with a current density of 640 mA/cm2 was simultaneously used for area specific resistance (ASR) studies. The coatings were characterized by X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), an energy dispersive spectrometer (EDS) and Raman spectroscopy. 相似文献
The Baltic Sea ecosystem and fish stocks contain high concentrations of environmental chemicals such as polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs), and polychlorinated biphenyls (PCBs). This study forecasts how changes in fishing or natural mortality would probably influence concentrations of PCDD/F and PCB in the Bothnian Sea (Northern Baltic) herring (Clupea harengus L.). An age-structured simulation model was developed to forecast herring stock dynamics, catches, and weight-at-age under different assumptions about exploitation and natural mortality. The simulated herring weight-at-age estimates were employed in a bioenergetics model capable of simultaneous estimation of bioaccumulation of 17 PCDD/F and 37 PCB congeners. Although the natural variability in recruitment greatly influences the stock dynamics, considerable changes in weight-at-age would ensue changes in exploitation rate or in natural mortality rate. If exploitation rates increase, growth rates would be higher and herring in the weight categories of commercial fisheries would be younger and contain less PCDD/F and PCB. Hence, the average toxicant concentrations in catches would also decline. However, it is likely that only fairly small changes would occur in toxicant concentrations-at-age. On the other hand, a drastic decrease in herring fishing would substantially increase PCDD/F and PCB concentrations in herring. The study indicated that, in spite of the clear influences of fishing on the toxicant concentrations, fishing alone cannot resolve the problems associated with a high concentration of toxicants in herring; further decreases in loading are still required. 相似文献
Our representation of peripersonal space does not always accurately reflect the physical world. An example of this is pseudoneglect, a phenomenon in which neurologically normal individuals bisect to the left of the veridical midpoint, reflecting an overrepresentation of the left portion of space compared with the right one. Consistent biases have also been observed in the vertical and radial planes. It is an open question whether these biases depend on normal visual experience for their occurrence. Here we systematically investigated this issue by testing blindfolded sighted and early blind individuals in a haptic line bisection task. Critically, we found a robust leftward bias in all participants. In the vertical and radial planes, sighted participants showed a consistent downward and proximal bias. Conversely, the directional bias in blind participants was dependent on the final movement direction; thus, there was no general bias in either direction. These findings are discussed in terms of different reference frames adopted by sighted and blind participants when encoding space. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献