In-vivo measurement of coronary stent dimensions throughout entire vascular segments with quantitative three-dimensional intravascular ultrasound: a review

The implantation of metallic endoprostheses (i. e., stents) is a rapidly expanding interventional technique for the catheter-based therapy of symptomatic patients with significant coronary stenoses. But stents are frequently radiolucent and after deployment difficult to appreciate on fluoroscopy and coronary angiograms obtained by x-ray. Intravascular ultrasound (IVUS), on the other hand, permits detailed examination of coronary stent apposition and expansion in vivo. Recently, automated systems for three-dimensional (3-D) reconstruction and analysis of IVUS images have been developed. The initial experience with 3-D IVUS in coronary stenting is positive. Different technical approaches demonstrated superiority of 3-D IVUS in detecting both, the site of the smallest in-stent lumen cross-sectional area and sub-optimal results following stent deployment. In-addition, the restenosis process inside stents can excellently be studied with IVUS. In-stent neointimal ingrowth can be exmined with a computerized 3-D contour detection system that permits off-line detection of the neointimal leading edge and the coronary stent struts. This 3-D approach provides computerized measurement of neointimal volume, based on a large number of IVUS images. Considering the current trend towards more complex coronary stenting procedures, a feasible and reliable 3-D analysis tool for clinical on-line assessment after stent deployment may also be very useful.     

Geometry and expected performance of the solid tungsten outer divertor row in JET

At JET new plasma-facing components for the main chamber wall and the divertor are being designed and built to mimic the expected ITER plasma wall conditions in the deuterium-tritium operation phase. The main wall elements at JET will be made of beryllium and the divertor plasma-facing surface will be made of tungsten. Most of the divertor tiles will consist of tungsten-coated Carbon Fibre Composite (CFC) material. However one toroidal row in the outer divertor will be made of solid, inertially cooled tungsten. The geometry of these solid tungsten divertor components is optimized within the boundary conditions of the interfaces and the constraints given by the electrodynamical forces. Shadowing calculations as well as rough field line penetration analysis is used to define the geometry of the tungsten lamella stacks. These calculations are based on a set of magnetic equilibria reflecting the operation domain of current JET plasma scenarios. All edges in poloidal and toroidal direction are shadowed to exclude near perpendicular field line impact. In addition, the geometry of the divertor structure is being optimized so that the fraction of the plasma wetted surface is maximised. On the basis of the optimized divertor geometry, performance calculations are done with the help of ANSYS to assess the maximum power exhaust possible with this inertially cooled divertor row.     

Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization

Epothilones are macrocyclic bacterial natural products with potent microtubule-stabilizing and antiproliferative activity. They have served as successful lead structures for the development of several clinical candidates for anticancer therapy. However, the structural diversity of this group of clinical compounds is rather limited, as their structures show little divergence from the original natural product leads. Our own research has explored the question of whether epothilones can serve as a basis for the development of new structural scaffolds, or chemotypes, for microtubule stabilization that might serve as a basis for the discovery of new generations of anticancer drugs. We have elaborated a series of epothilone-derived macrolactones whose overall structural features significantly deviate from those of the natural epothilone scaffold and thus define new structural families of microtubule-stabilizing agents. Key elements of our hypermodification strategy are the change of the natural epoxide geometry from cis to trans, the incorporation of a conformationally constrained side chain, the removal of the C3-hydroxyl group, and the replacement of C12 with nitrogen. So far, this approach has yielded analogs 30 and 40 that are the most advanced, the most rigorously modified, structures, both of which are potent antiproliferative agents with low nanomolar activity against several human cancer cell lines in vitro. The synthesis was achieved through a macrolactone-based strategy or a high-yielding RCM reaction. The 12-aza-epothilone ("azathilone" 40) may be considered a "non-natural" natural product that still retains most of the overall structural characteristics of a true natural product but is structurally unique, because it lies outside of the general scope of Nature's biosynthetic machinery for polyketide synthesis. Like natural epothilones, both 30 and 40 promote tubulin polymerization in vitro and at the cellular level induce cell cycle arrest in mitosis. These facts indicate that cancer cell growth inhibition by these compounds is based on the same mechanistic underpinnings as those for natural epothilones. Interestingly, the 9,10-dehydro analog of 40 is significantly less active than the saturated parent compound, which is contrary to observations for natural epothilones B or D. This may point to differences in the bioactive conformations of N-acyl-12-aza-epothilones like 40 and natural epothilones. In light of their distinct structural features, combined with an epothilone-like (and taxol-like) in vitro biological profile, 30 and 40 can be considered as representative examples of new chemotypes for microtubule stabilization. As such, they may offer the same potential for pharmacological differentiation from the original epothilone leads as various newly discovered microtubule-stabilizing natural products with macrolactone structures, such as laulimalide, peloruside, or dictyostatin.     

Attentional capture of objects referred to by spoken language.

Participants saw a small number of objects in a visual display and performed a visual detection or visual-discrimination task in the context of task-irrelevant spoken distractors. In each experiment, a visual cue was presented 400 ms after the onset of a spoken word. In experiments 1 and 2, the cue was an isoluminant color change and participants generated an eye movement to the target object. In experiment 1, responses were slower when the spoken word referred to the distractor object than when it referred to the target object. In experiment 2, responses were slower when the spoken word referred to a distractor object than when it referred to an object not in the display. In experiment 3, the cue was a small shift in location of the target object and participants indicated the direction of the shift. Responses were slowest when the word referred to the distractor object, faster when the word did not have a referent, and fastest when the word referred to the target object. Taken together, the results demonstrate that referents of spoken words capture attention. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Socio-economic status,racial composition and the affordability of fresh fruits and vegetables in neighborhoods of a large rural region in Texas

Background  

Little is known about how affordability of healthy food varies with community characteristics in rural settings. We examined how the cost of fresh fruit and vegetables varies with the economic and demographic characteristics in six rural counties of Texas.     

Tuned interactions of silver nanoparticles with ZSM-5 zeolite by adhesion-promoting poly(acrylic acid) deposited by electrospray ionization (ESI)

The electrospray ionization (ESI) method was used for deposition of thin films of poly(acrylic acid) (PAA) on Cu/ZSM-5 (5 wt.% Cu) and Ag–Cu/ZSM-5 (1 wt.% Ag and 4 wt.% Cu) composites. For comparative purposes, the ZSM-5 zeolite was synthesized under hydrothermal conditions and loaded with PAA under the same treating conditions as the composites. This method allowed the formation of uniform polymer films of controlled thickness on conductive substrates. The structural characteristics were characterized by X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, atomic force microscopy and X-ray diffraction (XRD). The deposited PAA layer over ZSM-5 acts as a common dispersing and stabilizing agent through coordination-driven guest-templated polymer via interaction of Ag⁺ and Cu²⁺ with carboxylic acid groups, thus increasing and controlling the adhesion and the release of metallic species. A short exposure to light and temperature has reduced the metal ions to Cu⁰ and Ag⁰ metallic nanoparticles. The results of XRD analysis let suggest that the interaction of Cu and Ag with carboxylic groups of PAA inhibits the formation of large metallic silver particles. These samples were being studied for their potential as antibacterial agents toward the bacterial strains such as Staphylococcus pneumonia, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa as Gram positive and Gram negative bacteria, respectively. Aspergillus fumigatus and Candida albicans as Fungi were also evaluated. The Cu/ZSM-5 and Ag–Cu/ZSM-5 nanocomposites coated with a 10 nm thick PAA layer exhibit significant antibacterial activity.     

振动信号短时分析方法及在机械故障诊断中的应用

研究了低信噪比情况下提取周期性冲击故障信号特征的短时分析方法。定量分析了短时能量方法的抑噪特征,指出信号的局部特征越明显则短时能量处理越能显著的提高信噪比,短时能量函数中实际有用信号能量与实际噪声信号能量的比值可作为一特征量使用。建立了信号的物理含义相同,反映的只是信号功率谱重心的变化,与信号能量的变化无关,故不适宜于分析受强噪声干扰的时变故障信号。最后以滚动轴承故障信号分析实例验证了短时能量分析