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31.
Pauline V. Marck Marco T. Pessoa Yunhui Xu Laura C. Kutz Dominic M. Collins Yanling Yan Cierra King Xiaoliang Wang Qiming Duan Liquan Cai Jeffrey X. Xie Jerry B. Lingrel Zijian Xie Jiang Tian Sandrine V. Pierre 《International journal of molecular sciences》2021,22(7)
The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of cardiac conditions, CTS inhibit the ion-pumping function of Na/K-ATPase. At much lower concentrations, in the range of those reported for endogenous CTS in the blood, they stimulate hypertrophic growth of cultured cardiac myocytes through initiation of a Na/K-ATPase-mediated and reactive oxygen species (ROS)-dependent signaling. To examine a possible effect of endogenous concentrations of CTS on cardiac structure and function in vivo, we compared mice expressing the naturally resistant Na/K-ATPase α1 and age-matched mice genetically engineered to express a mutated Na/K-ATPase α1 with high affinity for CTS. In this model, total cardiac Na/K-ATPase activity, α1, α2, and β1 protein content remained unchanged, and the cardiac Na/K-ATPase dose–response curve to ouabain shifted to the left as expected. In males aged 3–6 months, increased α1 sensitivity to CTS resulted in a significant increase in cardiac carbonylated protein content, suggesting that ROS production was elevated. A moderate but significant increase of about 15% of the heart-weight-to-tibia-length ratio accompanied by an increase in the myocyte cross-sectional area was detected. Echocardiographic analyses did not reveal any change in cardiac function, and there was no fibrosis or re-expression of the fetal gene program. RNA sequencing analysis indicated that pathways related to energy metabolism were upregulated, while those related to extracellular matrix organization were downregulated. Consistent with a functional role of the latter, an angiotensin-II challenge that triggered fibrosis in the α1r/rα2s/s mouse failed to do so in the α1s/sα2s/s. Taken together, these results are indicative of a link between circulating CTS, Na/K-ATPase α1, ROS, and physiological cardiac hypertrophy in mice under baseline laboratory conditions. 相似文献
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添加稀土引致的磷化膜变化与促进机制 总被引:1,自引:0,他引:1
邝钜炽 《腐蚀科学与防护技术》2006,18(3):190-191
用能谱与SEM分析,发现加入稀土硝酸盐(REN)后明显提高了无定形晶体Zn2Fe(PO4)2在磷化膜表面的覆盖率,而使得膜的耐蚀性能提高.此时膜内相关元素含量比例发生了变化:P增大,Zn减小,可见磷对膜耐蚀性的贡献比锌大.讨论认为,稀土硝酸盐是一个有良好载氧能力的催化剂,具有良好的成核促进作用和阴极去极化作用,从而能加速磷化并使膜的耐腐蚀性能提高.
相似文献
33.
测定了庚烯-(3)的蒸气压。用Gillespie型平衡器测定了甲苯—庚烯-(3)、正庚烷—庚烯-(3)二元系及甲苯—正庚烷—庚烯-(3)三元系统的平衡数据,并分别用Spinner及White方法验证了这些数据,计算结果与实验结果是符合的。三元系统气液平衡的数据不论在工程中或是实验工作上都很重要,过去对三元系统气液平衡的研究虽然有一些,但对甲苯—正庚烷—庚烯-(3)三元系统气液平衡至今在文献上尚未有记载。 由于庚烯-(3)的蒸气压数据不见于文献,我们测定了它的蒸气压数据。正庚烷—甲苯二元系统前人已有许多结果发表,我们进行了一些校核,结果与文献记载符合。甲苯—庚烯-(3)二元系统文献上没有,我们倣效了并用Spinner方法及White方法整理。至于正庚烷—庚烯-(3)二元系统,因为此两组分的性质(如沸点、n_D~(20)等)极其接近,分析误差较大,我们将其当作理想溶液处理,误差当在允许误差以内。 三元系统的分析较为繁难,误差也较大,故希望从理论和实验材料找出其规律性,以校核实验数据和推算未知三元系统。本工作利用三个二元系统的数据,用Spinner以及White的方法推算三元系统的气液平衡,与实验数据相比较,是相互符合的。 相似文献
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The new dust removal technical route using the carbon-granular bed filter,packed of carbon particles with appropriate grade derive from an online-process vibration sieve,to replace the traditional baggy filter had been developed successfully for capturing the micro-carbon dusts produced from pulverization of petroleum coke,and the green close loop of carbon materials is thus completed in the combined pulverizing and classifying system and pulverized carbon dust removal process.The high dust removal efficiency greater than 99%,low outlet dust concentration less than 100 mg.m-3,low pressure drop through dust filtration chamber less than 980 Pa,simple and easy design,and flexible and stable operation were achieved also with the carbon-granular bed filter in both bench and industrial scale operations. 相似文献
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KUANG Li FAN Shuanshi 《化工学报》2003,54(Z1):81-85
The effect of diluted solution's magnetization on induction time and growth period of natural gas hydrate (NGH) has been investigated in quiescent reaction system at pressure of 4.5 MPa and temperature of 274 K with SDS as surfactant, by using volume fixed and pressure falling method. Experimental results show that magnetization will have effect on the induction time of NGH. After magnetization with magnetic field intensity of 0.33 T, the induction time of NGH has been reduced to 47 min (average) from 99 min (average) in which there is no magnetization. On the other hand, the induction time has been prolonged after magnetization of the diluted solution with magnetic field intensity of 0.05 T, 0.11 T, 0.22 T, 0.44 T. Especially with magnetic field intensity of 0.11 T, the induction time had even been prolonged to 431 min (average). The effect of magnetization on the growth period of NGH has not been found at the experimental condition. 相似文献
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针对不同厂商、不同系统的楼宇自控设备互操作、互通信的局限性,分析了BACnet/IP技术和实时数据库,设计开发了一种基于BACnet/IP技术的实时数据库DasRdb的设备驱动程序。该设备驱动程序采用UDP通信方式,通过调用每个BACnet/IP设备的标准接口函数来驱动实时数据库DasRdb分别进行写操作和读操作,能够有效地实现BACnet/IP设备与实时数据库DasRdb之间的通信,从而使楼控设备的互操作成为可能。现场工程应用表明,该程序的运行契合BACnet的一致性要求,具有简单、高效、精确度高、实时性好的特点。 相似文献