Multi-scale modelling of elastic moduli of trabecular bone

We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.     

In vitro investigations of a novel wound dressing concept based on biodegradable polyurethane

Non-healing and partially healing wounds are an important problem not only for the patient but also for the public health care system. Current treatment solutions are far from optimal regarding the chosen material properties as well as price and source. Biodegradable polyurethane (PUR) scaffolds have shown great promise for in vivo tissue engineering approaches, but accomplishment of the goal of scaffold degradation and new tissue formation developing in parallel has not been observed so far in skin wound repair. In this study, the mechanical properties and degradation behavior as well as the biocompatibility of a low-cost synthetic, pathogen-free, biocompatible and biodegradable extracellular matrix mimicking a PUR scaffold was evaluated in vitro. The novel PUR scaffolds were found to meet all the requirements for optimal scaffolds and wound dressings. These three-dimensional scaffolds are soft, highly porous, and form-stable and can be easily cut into any shape desired. All the material formulations investigated were found to be nontoxic. One formulation was able to be defined that supported both good fibroblast cell attachment and cell proliferation to colonize the scaffold. Tunable biodegradation velocity of the materials could be observed, and the results additionally indicated that calcium plays a crucial role in PUR degradation. Our results suggest that the PUR materials evaluated in this study are promising candidates for next-generation wound treatment systems and support the concept of using foam scaffolds for improved in vivo tissue engineering and regeneration.     

Cell-based maximum entropy approximants for three-dimensional domains: Application in large strain elastodynamics using the meshless total Lagrangian explicit dynamics method

We present the cell-based maximum entropy (CME) approximants in E³ space by constructing the smooth approximation distance function to polyhedral surfaces. CME is a meshfree approximation method combining the properties of the maximum entropy approximants and the compact support of element-based interpolants. The method is evaluated in problems of large strain elastodynamics for three-dimensional (3D) continua using the well-established meshless total Lagrangian explicit dynamics method. The accuracy and efficiency of the method is assessed in several numerical examples in terms of computational time, accuracy in boundary conditions imposition, and strain energy density error. Due to the smoothness of CME basis functions, the numerical stability in explicit time integration is preserved for large time step. The challenging task of essential boundary condition (EBC) imposition in noninterpolating meshless methods (eg, moving least squares) is eliminated in CME due to the weak Kronecker-delta property. The EBCs are imposed directly, similar to the finite element method. CME is proven a valuable alternative to other meshless and element-based methods for large-scale elastodynamics in 3D. A naive implementation of the CME approximants in E³ is available to download at https://www.mountris.org/software/mlab/cme .     

High Dynamic Range Imaging and Low Dynamic Range Expansion for Generating HDR Content

In the last few years, researchers in the field of High Dynamic Range (HDR) Imaging have focused on providing tools for expanding Low Dynamic Range (LDR) content for the generation of HDR images due to the growing popularity of HDR in applications, such as photography and rendering via Image‐Based Lighting, and the imminent arrival of HDR displays to the consumer market. LDR content expansion is required due to the lack of fast and reliable consumer level HDR capture for still images and videos. Furthermore, LDR content expansion, will allow the re‐use of legacy LDR stills, videos and LDR applications created, over the last century and more, to be widely available. The use of certain LDR expansion methods, those that are based on the inversion of Tone Mapping Operators (TMOs), has made it possible to create novel compression algorithms that tackle the problem of the size of HDR content storage, which remains one of the major obstacles to be overcome for the adoption of HDR. These methods are used in conjunction with traditional LDR compression methods and can evolve accordingly. The goal of this report is to provide a comprehensive overview on HDR Imaging, and an in depth review on these emerging topics.     

Predicting Display Visibility Under Dynamically Changing Lighting Conditions

Display devices, more than ever, are finding their ways into electronic consumer goods as a result of recent trends in providing more functionality and user interaction. Combined with the new developments in display technology towards higher reproducible luminance range, the mobility and variation in capability of display devices are constantly increasing. Consequently, in real life usage it is now very likely that the display emission to be distorted by spatially and temporally varying reflections, and the observer's visual system to be not adapted to the particular display that she is viewing at that moment. The actual perception of the display content cannot be fully understood by only considering steady-state illumination and adaptation conditions. We propose an objective method for display visibility analysis formulating the problem as a full-reference image quality assessment problem, where the display emission under "ideal" conditions is used as the reference for real-life conditions. Our work includes a human visual system model that accounts for maladaptation and temporal recovery of sensitivity. As an example application we integrate our method to a global illumination simulator and analyze the visibility of a car interior display under realistic lighting conditions.     

Twenty years of telecommunications research in BIT

This paper reflects on 20 years of behavioural research in telecommunications published in BIT. The past 20 years have seen major changes in telecommunications technology and applications. They have also seen the deregulation of telecommunications markets and the pervasive penetration of the working environment by networked systems. Papers published in BIT have reflected these changes. Some research topics have attracted continuing interest throughout this period, and two are reviewed briefly: the effect of network delays on users and the relative effectiveness of different media and user choices between them. In addition many new technical and theoretical developments have been reported. Two major theoretical trends have been the convergence between behavioural research in telecommunications and computing, and the rise in social-science-based research. The question whether published behavioural research has been able to influence the development of the technologies studied is considered. Finally, the paper speculates on future topics for research.     

Monolithic Perovskite/Silicon Tandems with >28% Efficiency: Role of Silicon-Surface Texture on Perovskite Properties

Textured silicon wafers used in silicon solar cell manufacturing offer superior light trapping, which is a critical enabler for high-performance photovoltaics. A similar optical benefit can be obtained in monolithic perovskite/silicon tandem solar cells, enhancing the current output of the silicon bottom cell. Yet, such complex silicon surfaces may affect the structural and optoelectronic properties of the overlying perovskite films. Here, through extensive characterization based on optical and microstructural spectroscopy, it is found that the main effect of such substrate morphology lies in an altering of the photoluminescence response of the perovskite, which is associated with thickness variations of the perovskite, rather than lattice strain or compositional changes. With this understanding, the design of high-performance perovskite/silicon tandems is rationalized, yielding certified power conversion efficiencies of >28%.     

Reverse engineering approach to appearance-based design of metallic and pearlescent paints

We propose a new approach to interactive design of metallic and pearlescent coatings, such as automotive paints and plastic finishes of electronic appliances. This approach includes solving the inverse problem, that is, finding pigment composition of a paint from its bidirectional reflectance distribution function (BRDF) based on a simple paint model. The inverse problem is solved by two consecutive optimizations calculated in real-time on a contemporary PC. Such reverse engineering can serve as a starting point for subsequent design of new paints in terms of appearance attributes that are directly connected to the physical parameters of our model. This allows the user to have a paint composition in parallel with the appearance being designed.     

Broadcasting Spanning Forests on a Multiple-Access Channel

The problem of finding a spanning forest of a graph in a distributed-processing environment is studied. If an input graph is weighted, then the goal is to find a minimum-weight spanning forest. The processors communicate by broadcasting. The output consists of the edges that make a spanning forest and have been broadcast on the network. Input edges are distributed among the processors, with each edge held by one processor. The underlying broadcast network is implemented as a multiple-access channel. If exactly one processor attempts to perform a broadcast, then the broadcast is successful. A message broadcast successfully is delivered to all the processors in one step. If more than one processors broadcast simultaneously, then the messages interfere with each other and no processor can receive any of them. Optimality of algorithmic solutions is investigated, by way of comparing deterministic with randomized algorithms, and adaptive with oblivious ones. Lower bounds are proved that either justify the optimality of specific algorithms or show that the optimal performance depends on a class of algorithms.     

Safety and Danger Considerations of Novel Treatments for Atopic Dermatitis in Context of Primary Cutaneous Lymphomas

The impact of new and emerging therapies on the microenvironment of primary cutaneous lymphomas (PCLs) has been recently raised in the literature. Concomitantly, novel treatments are already used or registered (dupilumab, upadacitinib) and others seem to be added to the armamentarium against atopic dermatitis. Our aim was to review the literature on interleukins 4, 13, 22, and 31, and JAK/STAT pathways in PCLs to elucidate the safety of using biologics (dupilumab, tralokinumab, fezakinumab, nemolizumab) and small molecule inhibitors (upadacitinib, baricitinib, abrocitinib, ruxolitinib, tofacitinib) in the treatment of atopic dermatitis. We summarized the current state of knowledge on this topic based on the search of the PubMed database and related references published before 21 October 2021. Our analysis suggests that some of the mentioned agents (dupilumab, ruxolitinib) and others may have a direct impact on the progression of cutaneous lymphomas. This issue requires further study and meticulous monitoring of patients receiving these drugs to ensure their safety, especially in light of the FDA warning on tofacitinib. In conclusion, in the case of the rapid progression of atopic dermatitis/eczema, especially in patients older than 40 years old, there is a necessity to perform a biopsy followed by a very careful pathological examination.