Photo‐crosslinking of poly[ethene‐stat‐(methacrylic acid)] functionalised with maleimide side groups

BACKGROUND: Photo‐crosslinkable polymers are well known and commercially applied as photoresists. But so far they have not been applied as membrane materials for separation processes. They would offer certain advantages in membrane fabrication over conventional crosslinked polymer materials. Therefore, in this work, a poly[ethene‐stat‐(methacrylic acid)] (PEMAA) which is a potential membrane polymer for different separation problems was functionalised with photo‐crosslinkable maleimide side groups. RESULTS: It has been shown that PEMAA can be used as basic polymer material and a conversion with 3‐hydroxypropylmaleimide is possible in order to obtain a photo‐crosslinkable polymer. Investigation of the crosslinking mechanism was performed using stationary infrared and UV‐visible spectroscopy as well as nanosecond transient spectroscopy absorption measurements of a rotating film. Intense transient absorption of the maleimide‐esterified PEMAA occurs at 250 nm in the film pointing to maleimide anion formation and crosslinking via an ionic dimerisation mechanism. CONCLUSION: It is found that crosslinking reactions can be observed spectroscopically in situ using a maleimide‐functionalised PEMAA. Furthermore, experiments can be performed in the liquid phase (polymer in solution) as well as in the solid phase (polymer film) using a rotating polymer film sample. Maleimide anion formation and crosslinking via an ionic dimerisation mechanism can be investigated by variation of the polymer structure as well as the structure of the maleimide side groups. Copyright © 2009 Society of Chemical Industry     

Large‐Scale Preparation of Polymer Nanocarriers by High‐Pressure Microfluidization

Polymer nanocarriers are used as transport modules in the design of the next generation of drug delivery technology. However, the applicability of nanocarrier‐based technology depends strongly on our ability to precisely control and reproduce their synthesis on a large scale because their properties and performances are strongly dependent on their size and shape. Fundamental studies and practical applications of polymer nanocarriers are hampered by the difficulty of using the current methods to produce monodispersed nanocarriers in large quantities and with high reproducibility. Here, a versatile and scalable approach is reported for the large‐scale synthesis of polymer nanocarriers from water‐in‐oil miniemulsions. This method uses microfluidization to perform a controlled emulsification and is proven to be effective to prepare nanocarriers of different biopolymers (polysaccharides, lignin, proteins) up to 43 g min^?1 with reproducible size and distribution.     

Analysis of quality-of-service in a wide-area interactive distance learning system

Interactive distance learning (IDL) is an evolving paradigm of instruction and learning that attempts to overcome both distance and time constraints found in traditional classroom learning. The electronic classrooms at two sites of the University of Oslo and two further sites in Norway overcome separations in space by exchanging digital audio, video, and whiteboard information via the Norwegian academic ATM-based network Supernett II. The electronic classrooms are used since 1993 for teaching graduate level courses. This paper presents measurements and analysis results of transport, application, and user level Quality-of-Service (QoS) of the electronic classrooms. We describe our general experiences with this system for synchronous IDL. The lessons learned represent the motivation for the ongoing extension to support asynchronous IDL by a multimedia database system (MMDBS) to manage all data used and generated in the electronic classrooms.     

Absorption and elimination kinetics of zidovudine in the cerebrospinal fluid in HIV-1-infected patients

The first two surveys of the dental health of young Finnish men were conducted in 1919 and 1965. The objective of four subsequent surveys (1976, 1981, 1986, and 1991) was to collect both interview and clinical examination data for the monitoring of changes in the oral health status of the recruits. A significant reduction in self-reported toothache, gingival bleeding, and number of decayed teeth was observed from 1976 to 1991. At examination, the numbers of decayed teeth, teeth indicated for extraction, teeth in need of fillings, and missing teeth decreased substantially, as did the teeth with visible plaque, subgingival calculus, and teeth with 4-mm or deeper periodontal pockets. This comprehensive series of successive cross-sectional oral health surveys clearly shows that since 1976 a significant decrease in oral disease and treatment needs has taken place among the Finnish population of young men.     

Abusive testing of large Li/SOCl2 cells

Results are reported of various abuse tests conducted with lithium-thionyl chloride primary batteries of 2 000 A h and 10 000 A h capacity. The mechanical abuse tests, such as shock and vibration, showed that the large prismatic cells can now be built to satisfy typical military requirements. The thermal abuse tests showed that the cells can withstand a considerable overheating or a thermal shock treatment, as long as provisions were made for the thermal expansion of the electrolyte. The electrochemical abuse tests showed that the cells could be overdischarged (driven in reverse beyond discharge) to an equivalent of up to 50% of the discharge capacity with no adverse effects. The short circuit test, as a combination of the electrochemical and thermal abuse, was performed with no rupture, explosion or any other adverse effects on the surroundings.