Can EC-IC bypass prevent brain ischemia from recurring?

The effectiveness of extracranial-intracranial arterial bypass (EC-IC bypass) surgery for patients with hemodynamic compromise still remains controversial. In the present study, we evaluated the correlation between the pre- and post-surgical cerebral hemodynamics and long-term prognosis. 28 patients and a subsequent 21 patients (41 men, eight women: mean age 59.9 [S.D. 8.6] years) with reduced cerebrovascular reserve due to steno-occlusive disease of the cerebral major arteries formed the study groups 1 and 2, respectively. Measurement of the mean hemispheric cerebral blood flow (mCBF) and the cerebral vasoreactivity (%mCVR) with an intravenous acetazolamide injection were performed by a 133Xe inhalation method and SPECT. Patients were treated with EC-IC bypass surgery and measurement of mCBF and %mCVR were made again about one month after surgery. The patients were observed for a long period (mean 44.3 months). During the follow-up period, 6 patients experienced recurrent ischemic strokes. The annual incidence of recurrent ischemic stroke was 4.4%. The patients with significantly reduced pre- and post-surgical resting mCBF of the affected hemisphere were at significantly higher risk of recurrent ischemic stroke than the patients with normal mCBF (p < 0.01). The %mCVR of the affected hemisphere rose after surgery.     

The equivalent transmission-path model-a tool for analyzing errorfloor characteristics due to intersymbol interference in Nakagami-Ricefading environments

Land mobile radio systems such as car telephones and handy personal terminals used outdoors have enjoyed a remarkable evolution. To design reliable mobile radio systems, however, it is vital to have a good understanding of the impact of wave propagation characteristics on digital transmission quality in a wide variety of mobile radio environments. A very simple but general scheme for calculating irreducible bit error rate (BER) (namely, BER floor) due to intersymbol interference in frequency-selective Nakagami-Rice fading environments has been developed. The scheme, which we call the equivalent transmission-path model, plays a role in connecting wave propagation with digital transmission characteristics in a general manner. Through computer simulations assuming various types of delay profiles, we first identify key parameters of Nakagami-Rice fading dominating principally the occurrence of irreducible errors and we develop a simple method for the calculation of irreducible BER utilizing the nature or the key parameters. Then we examine the accuracy of the scheme for various types of phase-shift keying (PSK) transmission systems. Finally, based on the scheme, we show calculation examples of BER floor characteristics in line-of-sight fading environments     

The combined method: a novel access technique for fetal endoscopic surgery

BACKGROUND/PURPOSE: To develop practical and less invasive techniques for fetal endoscopic surgery, new methods of lifting the uterine wall to allow fetal surgery without maternal laparotomy were developed and assessed. METHODS: Fetal endoscopic surgical procedures, including tracheostomy and umbilical vascular cannulation, were performed using one of the three methods to enter the uterus without maternal laparotomy in pregnant goats (n = 6; 105 to 115 days' gestation): (1) direct uterine lifting with an air-cushion device; (2) indirect uterine lifting, in which the uterine wall was fixed to the maternal abdominal wall using balloon tip ports inserted percutaneously by Seldinger's method, then the maternal abdomen was lifted mechanically; and (3) combined method, in which low pressure CO2 (5 mm Hg for initial inflation and 2 mm Hg for maintenance) was insufflated into the uterus in addition to the indirect uterine lifting cited above. RESULTS: The direct uterine lifting caused massive injury of myometrium and uterine membranes. The creation of intrauterine space and the protection of the membranes were not accomplished effectively by the indirect uterine lifting only. The combined method provided the adequate intrauterine space and excellent endoscopic visibility for completion of the endoscopic procedures with minimal uterine injury. CONCLUSION: The fetal endoscopic surgery may be accomplished simply and safely by the combined method, a novel technique of uterine lifting to allow fetal surgery without maternal laparotomy.     

Periacinar collagenization in patients with chronic alcoholism

To examine the development of pancreatic fibrosis in alcoholics, the fibrosis types grouped according to Martin's classification were examined by immunohistochemistry using an antibody against alpha-smooth muscle actin (alpha-SMA). The initial stage of periacinar collagenization was also investigated by electron microscopy. The total incidence of pancreatic fibrosis at autopsy of the 29 alcoholics was significantly higher than that of the 40 non-alcoholics. Intralobular sclerosis was observed to be the most frequent type of fibrosis regardless of alcohol intake. No differences in the enhancement of alpha-SMA expression in each type of fibrosis were found between the alcoholics and non-alcoholics. Electron microscopically, myofibroblasts were found around acini in the early stage of periacinar collagenization, and were accompanied by numerous fine filaments (8-15 nm in diameter). The various changes in zymogen granules (ZG), lysosomes and lipid droplets were augmented in the acinar cells of alcoholics. Medium-density materials were also found in dilated rough endoplasmic reticulum (RER). The contents of ZG and RER occasionally leaked out. In conclusion, pancreatic fibrosis was increased in alcoholics; myofibroblasts may play an important role in the initial stage of periacinar collagenization; and the intracellular transport blockage of protein as represented by abnormalities of ZG, ER and lysosomes may contribute to the development of periacinar collagenization.     

Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in rats

A computer aided monitor-data processing system (CAMP-System) was developed in order to get a consistent and comprehensive database which can very precisely reflect intra-operative haemodynamic courses. The goal of the present study was to introduce a new method to scan and to gauge haemodynamic courses and to demonstrate its superiority over the traditional way of data processing based on a handwritten anaesthesia protocol. METHODS: The computerized system was applied to a study which was designed to investigate the influence of ketanserin (K) vs. urapidil (U) on haemodynamic stability during cardiac operations. Twenty male patients scheduled for myocardial revascularization received either 20 mg K or 30 mg U. Heart rate, central venous, arterial and pulmonary artery pressures were measured and on-line recorded every 20 seconds by the computer record system. In the handwritten protocol these variables were registered at eight pre-defined time points. Computerized data processing (including artifact depletion and data condensation) was compared to the results evaluated from the handwritten protocol. RESULTS: While the only significant differences in the handwritten protocol were slightly higher values of pulmonary artery pressures in group K, the computer analysis revealed a number of further differences. Higher maximum and a less stable time course of HR in group K in the pre-bypass phase and lower mean and standard deviation of MAP during cardiopulmonary bypass. CONCLUSION: Computerized data processing including automatic artifact suppression and data condensation was able to reveal differences in the course of haemodynamic variables that cannot be detected in a conventional handwritten protocol.     

Path planning for an autonomous mobile robot considering a region with a velocity constraint in a real environment

Recently, many research projects and competitions have attempted to find an autonomous mobile robot that can drive in the real world. In this article, we consider a path-planning method for an autonomous mobile robot that would be safe in a real environment. In such a case, it is very important for the robot to be able to identify its own position and orientation in real time. Therefore, we applied a localization method based on a particle filter. Moreover, in order to improve the safety of such autonomous locomotion, we improved the path-planning algorithm and the generation of the trajectory so that it can consider a region with a limited maximum velocity. In order to demonstrate the validity of the proposed method, we participated in the Real World Robot Challenge 2010. The experimental results are given.     

Temperature-stable low-noise ferrite memory cores

Temperature-stable low-noise memory cores made from the substituted lithium and nickel ferrites were studied. Ferrite compositions which are suitable for miniature cores have been developed by studying magnetic properties of the ferrite in the system Li-M-M' and Ni-M-M' ferrite (M:Mn, Fe, Co, Ni, Cu, and Zn). Technological approaches for fabricating small memory cores were made by studying the effect of ferrite-powder parameters and sintering conditions on magnetic properties of the substituted ferrites. Typical pulse characteristics taken with coincident current mode for cores of 0.48, 0.32, and 0.27 mm φ OD are presented. It was found that the Ni-Mn-F(II) ferrites are suitable for a low-drive high signal-to-noise ratio (dV1/dVz) temperature-stable memory core.     

New amphoteric surfactants containing a phosphoric acid group: I. syntheses and physicochemical properties of sodium 2-(n-2-hydroxyalkyl-n-methylamino)ethyl hydrogen phosphate

A series of new amphoteric surfactants having a phosphoric acid group, a tertiary amino group and a 2-hydroxyalkyl group, sodium 2-(N-2-hydroxyalkyl-N-methyl-amino)ethyl hydrogen phosphates (alkyl: n-tetradecyl, n-hexadecyl, n-octadecyl), were prepared by an addition reaction of 1,2-epoxyalkanes to N-methylaminoethanol, followed by the introduction of a phosphoric acid group and neutralization with sodium hydroxide. The structures of these compounds were confirmed by spectroscopy and elemental analysis. The solubility in solvents, Krafft point, surface tension, critical micelle concentration (CMC), occupation area of the molecule at the surface of aqueous solutions and foaming power were measured. It was shown that a 2-hydroxyethyl group in a long alkyl chain seemed to behave as a hydrophobic part.     

The distribution of soap in the polymerization system for preparation of carboxylated polystyrene latexes

The distribution of soap in the polymerization system for preparation of carboxylated polystyrene latexes has been investigated. The critical micelle concentration (CMC) for sodium dodecyl sulfate (SDS) in the polymerization system was determined by surface tension measurement to be 0.173 mmole/l. The solubility of styrene (St) in the aqueous phase of the polymerization system was determined by NMR measurement to be 4.52 mmole/l. It was confirmed by NMR measurement that at the concentration of SDS higher than the CMC, St is solubilized in the interior of the SDS micelles, and the concentration of solubilized St is almost proportional to the concentration of micellar SDS. From this relationship, the number and radius of SDS micelles containing solubilized St can be determined.     

Effect of changing groundwater levels caused by land-use changes on greenhouse gas fluxes from tropical peat lands

Monthly measurements of carbon dioxide (CO₂), methane (CH₄) and nitrous oxide (N₂O) fluxes in peat soils were carried out and compared with groundwater level over a year at four sites (drained forest, upland cassava,upland and lowland paddy fields) located in Jambi province, Indonesia. Fluxes from swamp forest soils were also measured once per year as the native state of this investigated area. Land-use change from drained forest to lowland paddy field significantly decreased the CO₂ (from 266 to 30 mg C m^–2 h^–1) and N₂O fluxes (from 25.4 to 3.8 g N m^–2 h^–1), but increased the CH₄ flux (from 0.1 to 4.2 mg C m^–2 h^–1) in the soils. Change from drained forest to cassava field significantly increased N₂O flux (from 25.4 to 62.2 g N m^–2 h^–1), but had no significant influence on CO₂ (from 266 to 200 mg C m^–2 h^–1) and CH₄ fluxes (from 0.1 to 0.3 mg C m^–2 h^–1) in the soils. Averaged CO₂ fluxes in the swamp forests (94 mg C m^–2 h^–1) were estimated to be one-third of that in the drained forest. Groundwater levels of drained forest and upland crop fields had been lowered by drainage ditches while swamp forest and lowland paddy field were flooded, although groundwater levels were also affected by precipitation. Groundwater levels were negatively related to CO₂ flux but positively related to CH₄ flux at all investigation sites. The peak of the N₂O flux was observed at –20 cm of groundwater level. Lowering the groundwater level by 10 cm from the soil surface resulted in a 50 increase in CO₂ emission (from 109.1 to 162.4 mg C m^–2 h^–1) and a 25% decrease in CH₄ emission (from 0.440 to 0.325 mg C m^–2 h^–1) in this study. These results suggest that lowering of groundwater level by the drainage ditches in the peat lands contributes to global warming and devastation of fields. Swamp forest was probably the best land-use management in peat lands to suppress the carbon loss and greenhouse gas emission. Lowland paddy field was a better agricultural system in the peat lands in terms of C sequestration and greenhouse gas emission. Carbon loss from lowland paddy field was one-eighth of that of the other upland crop systems, although the Global Warming Potential was almost the same level as that of the other upland crop systems because of CH₄ emission through rice plants.