Disposable potentiometric citrate sensor based on polypyrrole‐doped films for indirect determination of sildenafil in pharmaceuticals formulations

A new sensitive and selective disposable potentiometric sensor based on polypyrrole (PPy) films for determination of sildenafil citrate (SC) was proposed. The pyrrole polymerization was performed in presence of citrate ions under galvanostatic conditions which resulted in a membrane of PPy doped with citrate anion at graphite pencil electrode surface. Experimental conditions (e.g., pH and conditioning time) and instrumental parameters (e.g., current density and electrical charge) were evaluated in order to reach the best potentiometric response for the proposed sensor. Under optimized conditions, the device presented a linear dynamic range (LDR) for citrate ions concentrations varying from 0.034 to 1.7 mmol L^?1 with a Nernstian slope of 57.2 mV dec^?1 and a limit of detection (LOD) of 30 µmol L^?1. The developed potentiometric sensor was applied for sildenafil citrate (SC) determination (pharmaceutical formulations) and results compared with an official spectrophotometric method indicating a good agreement for a confidence level of 95%. Effect of concomitants species on the potentiometric response of the proposed device and morphologic characterization using microscopy of atomic force (AFM) were realized. The surface roughness of PPy films (synthesized in citrate solution and chloride) showed poorly affected by changing the doping anion, probably because the polypyrrole nodules grow three‐dimensionally simultaneously. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43762.     

A PSS‐Free PEDOT Conductive Film Supported by a Hierarchical Nanoporous Layer Glass

The importance of transparent conductive film is increasing due to its use in applications such as touch‐panel devices. Although indium tin oxide is widely used because of its high conductivity and transparency, conductive polymers are being studied as alternative materials that avoid the use of rare metals and the brittleness associated with existing systems. Polyethylene dioxythiophene (PEDOT)/polyethylene sulfonic acid (PSS) is drawing a lot of attention due to its well‐balanced conductivity, transparency, film formability, and chemical stability. The nonconductive PSS reportedly covers the conductive PEDOT. The PSS shell provides carrier and film‐formability to PEDOT but is also a barrier that hinders electrical conductivity. Therefore, the PEDOT film formability is explored supported by a substrate without the addition of PSS. The “hierarchical nanoporous layer glass” holds the PSS‐free PEDOT with its nanopores to form a homogeneous, transparent film. The PSS‐free PEDOT film thus achieves transparency of over 85% and resistivity of below 500 Ω sq^?1.     

Magnetic Field–Temperature Phase Diagram of Quasi-Two-Dimensional Organic Conductors Under Magnetic Fields

Under magnetic fields perpendicular to the conductive plane in quasi-two-dimensional organic conductors: -(BEDT-TTF)₂ MHg(SCN)₄ (M= K, Rb, and Tl), the experimentally reported H–T phase diagram has been explained partially. By the self-consistent numerical calculation including the quantum magnetic oscillation and the magnetic breakdown; in addition to the imperfectness of the SDW nesting, we try to completely understand the phase diagram.     

3D reconstruction considering calculation time reduction for linear trajectory shooting and accuracy verification with simulator

Artificial Life and Robotics - Photogrammetry is a three-dimensional (3D) reconstruction from images. In photogrammetry, when each image captures the features of the target object for 3D...     

Consumer confusion from price competition and excessive product attributes under the curse of dimensionality

AI & SOCIETY - The purpose of our study is to (i) investigate the effects of the number of products, product attributes, and prices on consumer confusion, (ii) conduct a numerical analysis to...     

Stress disturbance due to broken fibres in metal matrix composites with non-uniform fibre spacing

Premature fracture of weaker fibres causes stress disturbances in composites. These disturbances are affected by non-uniformity of fibre spacing. In order to evaluate quantitatively how the disturbances in metal matrix composites are affected by the extent of non-uniformity of fibre spacing, a method of calculation is presented on the basis of two-dimensional shear lag analysis. Static tensile stress concentrations in the intact fibres to broken fibres, tensile stress distribution along the fibre axis in the broken and intact fibres and shear stresses between broken and intact fibres were calculated by the method presented, using some examples. It is shown quantitatively that the spacing between broken and intact fibres and that between intact and next fibres has a significant influence on tensile stress concentrations in intact fibres and also on the shear stresses between broken and intact fibres: the narrower the former spacing and the wider the latter spacing, the higher become both tensile and shear stress concentrations. This tendency is enhanced when the number of broken fibres is large and when the strain hardening of the matrix is high.     

New integral experiments for large angle scattering cross section data benchmarking with DT neutron beam at JAEA/FNS

A new integral experiment with a deuteron–triton fusion (DT) neutron beam started in order to validate scattering cross section data. First the DT neutron beam was constructed with a collimator. The performance of the collimator system and the characteristics of the DT neutron beam were measured. Second a new integral experiment for type 316 stainless steel (SS316) was carried out with this DT neutron beam. The DT neutron beam of 3.5 cm in diameter was injected to the front surface center of an SS316 cylindrical assembly. Reaction rates of the ⁹³Nb(n,2n)^92mNb reaction in the assembly were measured with the activation foil method and were calculated with the Monte Carlo transport calculation code. The measurement points were located at three positions, on the center of the beam axis and at 15 cm and 30 cm apart from the axis. The ratio of calculation to experiment of the ⁹³Nb(n,2n)^92mNb reaction rate became smaller than 1 with the distance from the beam axis. Then, the dependency of each reaction rate on scattering angle was calculated. It was proved that at off-axis positions, where C/E is smaller than 1, 90° scattering contribute relatively larger than at on-axis positions and backward scattering made little contribution to the results in this experiment. The reasons of the discrepancy between the measured and calculated data will be investigated.     

Effect of sweep gas species on tritium release behavior from lithium titanate packed bed during 14 MeV neutron irradiation

In a fusion reactor, the prediction of tritium release behavior from breeder blanket is important to design the tritium recovery system, but the amount of tritium generated is necessary information to do that. Hence, tritium generation and recovery studies on lithium ceramics packed bed have been started by using fusion neutron source (FNS) in Japan Atomic Energy Agency (JAEA). Lithium titanate (Li₂TiO₃) was selected as tritium breeding material, and its packed bed was enclosed by the beryllium blocks, and was kept at certain temperature during fusion neutron irradiation. During irradiation, the packed bed was purged with the sweep gas continuously, and tritium released was trapped in each gas absorber selectively by chemical form. In this work, the effect of sweep gas species on tritium release behavior was investigated. In the case of sweep by helium with 1% of hydrogen, tritium in water form was released sensitively corresponding to the irradiation. This is due to existence of the water vapor in the sweep gas. On the other hand, in the case of sweep by helium without water vapor, tritium in gaseous form was released first, and release of tritium in water form was delayed from gaseous tritium and was gradually increased.