Structural-symmetry-related sequence patterns of the proteins of beta-propeller family

It is still not very clear to what extent and how does the amino acid sequences of proteins determine their tertiary structures. In this paper, we report our investigations of the sequence-structure relations of the proteins in the beta-propeller fold family, which adopt highly symmetrical tertiary structures while their sequences appear "random". We analyzed the amino acid sequences by using a similarity matrix plus Pearson correlation method and found that the sequences can show the same symmetries as their tertiary structures only if we deduce the conditions of sequence similarity. This suggests that some key residues may play an important role in the formation of the tertiary structures of these proteins.     

Physiological and psychophysical responses in handling maximum acceptable weights under different footwear--floor friction conditions

A study on combined manual materials-handling tasks performed on floors under three friction levels was conducted. Eight male subjects participated in the study. The maximum acceptable weight of handling, including lifting, carrying for 3m, lowering, and walking 3m back at twice per minute was determined. The subject then performed the same tasks for 10 min. Heart rate, Vo2, energy efficiency, perceived sense of slip, and rating of perceived exertion for whole body strain were measured. The results showed that the effects of friction level on the maximum acceptable weights of handling, perceived sense of slip, Vo2, and energy efficiency were statistically significant (p相似文献   

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Self-clocking principle for congestion control in the Internet

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