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91.
Kevin Munoz Samiksha Wasnik Amir Abdipour Hongzheng Bi Sean M. Wilson Xiaolei Tang Mahdis Ghahramanpouri David J. Baylink 《International journal of molecular sciences》2021,22(10)
Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study aimed to develop a therapy to normalize the excess production of inflammatory cytokines and promote tissue repair in the lipopolysaccharide (LPS)-induced ALI. Based on our previous studies, we tested the insulin-like growth factor I (IGF-I) and BTP-2 therapies. IGF-I was selected, because we and others have shown that elevated inflammatory cytokines suppress the expression of growth hormone receptors in the liver, leading to a decrease in the circulating IGF-I. IGF-I is a growth factor that increases vascular protection, enhances tissue repair, and decreases pro-inflammatory cytokines. It is also required to produce anti-inflammatory 1,25-dihydroxyvitamin D. BTP-2, an inhibitor of cytosolic calcium, was used to suppress the LPS-induced increase in cytosolic calcium, which otherwise leads to an increase in proinflammatory cytokines. We showed that LPS increased the expression of the primary inflammatory mediators such as toll like receptor-4 (TLR-4), IL-1β, interleukin-17 (IL-17), TNF-α, and interferon-γ (IFN-γ), which were normalized by the IGF-I + BTP-2 dual therapy in the lungs, along with improved vascular gene expression markers. The histologic lung injury score was markedly elevated by LPS and reduced to normal by the combination therapy. In conclusion, the LPS-induced increases in inflammatory cytokines, vascular injuries, and lung injuries were all improved by IGF-I + BTP-2 combination therapy. 相似文献
92.
Catherine M. Davis Wenri H. Zhang Elyse M. Allen Thierno M. Bah Robert E. Shangraw Nabil J. Alkayed 《International journal of molecular sciences》2021,22(11)
Soluble epoxide hydrolase (sEH) is abundant in the brain, is upregulated in type 2 diabetes mellitus (DM2), and is possible mediator of ischemic injury via the breakdown of neuroprotective epoxyeicosatrienoic acids (EETs). Prophylactic, pre-ischemic sEH blockade with 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid (tAUCB) reduces stroke-induced infarct in normal and diabetic mice, with larger neuroprotection in DM2. The present study tested whether benefit occurs in normal and DM2 mice if tAUCB is administered after stroke onset. We performed 60 min middle cerebral artery occlusion in young adult male C57BL mice divided into four groups: normal or DM2, with t-AUCB 2 mg/kg or vehicle 30 min before reperfusion. Endpoints were (1) cerebral blood flow (CBF) by laser Doppler, and (2) brain infarct at 24 h. In nondiabetic mice, t-AUCB reduced infarct size by 30% compared to vehicle-treated mice in the cortex (31.4 ± 4 vs. 43.8 ± 3 (SEM)%, respectively) and 26% in the whole hemisphere (26.3 ± 3 vs. 35.2 ± 2%, both p < 0.05). In contrast, in DM2 mice, tAUCB failed to ameliorate either cortical or hemispheric injury. No differences were seen in CBF. We conclude that tAUCB administered after ischemic stroke onset exerts brain protection in nondiabetic but not DM2 mice, that the neuroprotection appears independent of changes in gross CBF, and that DM2-induced hyperglycemia abolishes t-AUCB-mediated neuroprotection after stroke onset. 相似文献
93.
Slater Carl Bandi Bharath Dastur Pedram Davis Claire 《Metallurgical and Materials Transactions A》2022,53(6):2286-2299
Metallurgical and Materials Transactions A - Banding in commercial dual-phase steels, such as banded ferrite and pearlite or ferrite and martensite microstructures, is inherited from segregation... 相似文献
94.
B. M. Davis F. Sebba 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1966,16(10):297-300
A flotation circuit operating on a continuous basis has been designed and constructed for removal of Sr ions from simple aqueous solutions. Under steady-state conditions, a continuous extraction rate of 97.3% has so far been achieved. The effects of changing the gas rate and flow rates of both the Sr and collector solutions were also examined. Finally a discussion is included where the results of these experiments are compared with those from similar continuous-scale experiments where Sr ions are removed by the technique of foam separation. 相似文献
95.
The Lovász ?-function (Lovász in IEEE Trans. Inf. Theory, 25:1–7, 1979) of a graph G=(V,E) can be defined as the maximum of the sum of the entries of a positive semidefinite matrix X, whose trace Tr(X) equals 1, and X ij =0 whenever {i,j}∈E. This function appears as a subroutine for many algorithms for graph problems such as maximum independent set and maximum clique. We apply Arora and Kale’s primal-dual method for SDP to design an algorithm to approximate the ?-function within an additive error of δ>0, which runs in time $O(\frac{\vartheta ^{2} n^{2}}{\delta^{2}} \log n \cdot M_{e})$ , where ?=?(G) and M e =O(n 3) is the time for a matrix exponentiation operation. It follows that for perfect graphs G, our primal-dual method computes ?(G) exactly in time O(? 2 n 5logn). Moreover, our techniques generalize to the weighted Lovász ?-function, and both the maximum independent set weight and the maximum clique weight for vertex weighted perfect graphs can be approximated within a factor of (1+?) in time O(? ?2 n 5logn). 相似文献
96.
Robert A. Moreau David B. Johnston Kevin B. Hicks 《Journal of the American Oil Chemists' Society》2007,84(11):1039-1044
All commercial corn oil is obtained by pressing corn germ and/or extracting the germ with hexane. In the current study, six
types of corn oil were prepared by extracting corn germ, corn fiber and ground corn, each with hexane or with ethanol. The
levels of lutein, zeaxanthin and other carotenoids were quantitatively analyzed in the six corn oils. The levels of lutein + zeaxanthin
in the oil ranged from 2.3 μg/g for hexane-extracted corn germ oil to 220.9 μg/g for ethanol-extracted ground corn oil. These
results indicate that a diet that includes 30 g (~2 tbsp) per day of the unrefined corn oil obtained by extracting ground
corn with ethanol would provide ~6 mg of lutein + zeaxanthin, the daily dosage that is currently considered to be necessary
to slow the progression of age-related macular degeneration.
Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information
and does not imply recommendation or endorsement by the U.S. Department of Agriculture. 相似文献
97.
Lianhang Ma Hao Huang Qinming He Kevin Chiew Zhenguang Liu 《Journal of Intelligent Information Systems》2014,43(1):183-203
Local community detection aims at finding a community structure starting from a seed which is a given vertex in a network without global information, such as online social networks that are too large and dynamic to ever be known fully. Nonetheless, the existing approaches to local community detection are usually sensitive to seeds, i.e., some seeds may lead to missing of some true communities. In this paper, we present a seed-insensitive method called GMAC and its variation iGMAC for local community detection. They estimate the similarity among vertices by investigating vertices’ neighborhoods, and reveal a local community by maximizing its internal similarity and minimizing its external similarity simultaneously. Extensive experimental results on both synthetic and real-world data sets verify the effectiveness of our algorithms. 相似文献
98.
We present several novel techniques to summarize the high-level behavior in surveillance video. Our proposed methods can employ either optical flow or trajectories as input, and incorporate spatial and temporal information together, which improve upon existing approaches for summarization. To begin, we extract common pathway regions by performing graph-based clustering on similarity matrices describing the relationships between location/orientation states. We then employ the activities along the pathway regions to extract the aggregate behavioral patterns throughout scenes. We show how our summarization methods can be applied to detect anomalies, retrieve video clips of interest, and generate adaptive-speed summary videos. We examine our approaches on multiple complex urban scenes and present experimental results. 相似文献
99.
Halogen-free flame retardant additives based on phosphorus function by developing a protective char. A variety of additives are available, ranging from the element itself, in the form of amorphous red phosphorus, to specialty organophosphorus compounds, and examples of their use in a range of thermoplastics are given. Intumescent formulations based on phosphates are especially designed for polyolefins. The behavior of a typical intumescent system is described with respect to flame retardant performance, thermal stability, water sensitivity, and filler compatibility. 相似文献
100.
An in-situ corrosion sensor was used to obtain electrochemical impedance spectroscopy (EIS) measurements on coated panels
under a variety of accelerated laboratory test conditions as well as ambient exposure at a Florida beach. Three studies are
reported. The first compared the sensor (EIS) measurements taken in a salt fog chamber to those obtained using a clamp-on
cell and the conventional remote electrode/immersion approach. For coatings with minimal edge defects, the two methods gave
equivalent results. For coatings with edge defects, the sensor was able to detect the defects provided the surface was wet,
as in the salt fog chamber. In contrast, the conventional approach was unable to detect defects unless they were within the
confines of the clamp-on cell. In the second case, sensor measurements were used to compare coating degradation during salt
fog, a cyclic corrosion test, humidity, and immersion to that occurring at a Florida beach. The cyclic corrosion test showed
an excellent correlation with beach exposure while the salt fog and other test showed very little correlation, suggesting
that the cyclic test is more valid for discriminating coating performance for seacoast exposure. The sensor also indicated
that the test could be short-ened by up to 40% without significantly reducing the validity of the test. In the final example,
a series of primers and appliqués were evaluated using the cyclic corrosion test. The sensor EIS results allowed a discrimination
between the materials sets even though there was little or no visual difference between the specimens.
10260 Old Columbia Rd., Columbia, MD 21046. 相似文献