Mobilization of lead from human bone tissue during pregnancy and lactation--a summary of long-term research

The skeleton is potential endogenous source of lead during pregnancy and lactation. We have undertaken a longitudinal investigation into the mobilization of lead from the human maternal skeleton to determine whether lead is mobilized from the maternal skeleton during pregnancy and lactation, and if so, when and how much is released. Subjects in the study were migrants to Australia (n=15) whose skeletal lead isotopic composition (endogenous lead) was different to that prevailing in the Australian environment (exogenous lead). This migrant cohort was compared with 6 multi-generational Australian controls. Biological and environmental samples were taken pre-pregnancy where possible, throughout pregnancy and postpartum for at least 6 months. Newly-born infants of the migrant and Australian mothers were monitored for 6 months. Blood lead concentrations for the migrant mothers ranged from 1.5 to 20 microg/dl (geometric mean 2.8) and for Australian mothers ranged from 1.9 to 4.3 microg/dl (geometric mean 2.9). There was minimal change in lead isotopic composition of the Australian pregnant controls although there were increases of approximately 40% in blood lead concentration in 3 of 6 cases during the postpartum period and from 0 to 12% in the other 3. In the migrant pregnant subjects, the geometric mean skeletal lead contribution to blood lead using the isotopic composition was approximately 33% (range 10-88%) for 14 subjects using a revised estimate for exogenous lead. Skeletal contribution to blood lead during the postpartum period was significantly greater than during pregnancy (P<0.001). The skeletal contributions to blood lead are higher and the changes are more consistent in those subjects who conceived within 100 days of arrival in Australia compared with those who conceived longer than 100 days. In the migrant subjects, changes in blood lead concentration during pregnancy and postpartum varied from subject to subject with an overall 20% increase; the increases during the postpartum period were greater than during pregnancy (P<0.001). It was estimated that the amount of maternal skeletal lead mobilized during pregnancy and transferred to the infant via cord blood averaged approximately 79%. The increased skeletal contribution to blood lead is attributed to a low daily calcium intake of approximately 500 mgCa/day, a condition which was present in both migrant and Australian subjects. An ongoing clinical trial is providing a new cohort with calcium supplements. A summary of other aspects of the study is included and covers: additional flux released from the skeleton during pregnancy and postpartum; XRF bone lead results; urinary excretion of lead during pregnancy and postpartum; dietary contribution to blood lead in female adults and children; comparison of rates of exchange of lead in blood of newly-born infants and mothers; relationships of lead in breast milk to lead in blood, urine and diet of the infant and mother; changes in blood lead after cessation of breastfeeding; urinary lead isotopes during pregnancy and postpartum indicate no preferential partitioning of endogenous lead into plasma; a comparison of some aspects of the nonhuman primate and human pregnancy studies.     

ASSESSING AND MANAGING THE RISKS OF PATHOGEN TRANSFER FROM LIVESTOCK MANURES INTO THE FOOD CHAIN

A review was undertaken of (a) the levels and prevalence of Salmonella spp., Campylobacter spp., Listeria monocytogenes, Escherichia coli 0157. Cryptosporidium parvum and Giardia intestinalis in livestock manure, and (b) factors which affect their survival during storage and following land application. Pathogens are commonly present in livestock manures and can survive in soil for several months or years after spreading or excretion onto land. Temperature was identified as being the most important factor influencing pathogen survival, although pH, UV light and drying were also important. Various practical measures to minimise the risk of pathogen transfer into the food chain were identified, including treatment, extended storage and no/harvest periods following land spreading. Guidelines are being developed on managing farm manures to minimise the risks of microbiological contamination of ready-to-eat crops.     

Full scale fire tests for ship accommodation quarters

Ten full-scale test fires were conducted in a chamber simulating a three person ship accommodation quarter. The test fires used three different ventilation conditions, two types of bunks and furnishings with either polyurethane foam or chloroprene foam. The chamber was instrumented to follow the development of the fire.The furnishings with polyurethane foam were readily ignited and produced an intense fire within 2 to 4 minutes. The furnishings with chloroprene foam ignited but burned slowly with a small flame or in smoldering combustion.The ventilation conditions had a significant effect on the development and intensity of the fire as the test fires were burning under oxygen-limiting conditions.The solid pan bunks retarded the early development of the fire compared to open bunks for polyurethane furnishings. However, once the mattresses on the three bunks were ignited the intensity of the test fires was similar for both types of bunks.     

An experimental determination of combustibility

The author describes a laboratory method for determining ignitability, rate of heat release, and total heat release as a measure of the combustibility of materials. The results may be applied to building design and designation of contents with an eye towards reducing the possibility of a major fire. Note: Professor Smith is Director of Chemical Engineering Research, Engineering Experiment Station, The Ohio State University, Columbus, Ohio.     

Oxygen transfer in a rotating disc treatment plant

In this paper experiments are described in a bio-disc pilot plant. A new method has been developed for a reproducible measurement of the thickness of the waterfilm on the rotating discs. The results were used to calculate the oxygen transfer coefficient into water (K_L). The values of K_L, calculated in this way, appeared to be considerably higher than experimental K_L-values, which is mainly due to the fact that the water layer on the rotating disc is outdistanced by the disc. This effect has not been taken into account in the literature so far.     

Treatment capability of a physical—Chemical package plant

A short-term study of a commercially-available physical—chemical waste treatment plant is reported. Results indicate that an excellent quality of effluent can be consistently obtained despite wide fluctuations of influent wastewater characteristics. Physical, chemical, and biological parameters were monitored. The short-term data obtained offer some evidence of superior treatment efficiency in terms of COD, color, turbidity, and phosphorus removals when compared to more conventional treatment methods.     

西安市金华北路邮政局营业楼裂缝分析

本文用弦线模量计算了营业楼地基的压缩变形和湿陷变形,以及由它们引起的差异沉降值和局部倾斜。计算结果和楼房的裂缝情况吻合。计算湿陷变形时考虑地基浸水后的含水量为30.00％,这是由实测情况确定。根据浸水的实际状况计算建筑物的湿陷变形,分析工程事故在文献中似未见到。