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101.
Klaus Julisch Christophe Suter Thomas Woitalla Olaf Zimmermann 《Computers & Security》2011,30(6-7):410-426
System and process auditors assure – from an information processing perspective – the correctness and integrity of the data that is aggregated in a company’s financial statements. To do so, they assess whether a company’s business processes and information systems process financial data correctly. The audit process is a complex endeavor that in practice has to rely on simplifying assumptions. These simplifying assumptions mainly result from the need to restrict the audit scope and to focus it on the major risks. This article describes a generalized audit process. According to our experience with this process, there is a risk that material deficiencies remain undiscovered when said simplifying assumptions are not satisfied. To address this risk of deficiencies, the article compiles thirteen control patterns, which – according to our experience – are particularly suited to help information systems satisfy the simplifying assumptions. As such, use of these proven control patterns makes information systems easier to audit and IT architects can use them to build systems that meet audit requirements by design. Additionally, the practices and advice offered in this interdisciplinary article help bridge the gap between the architects and auditors of information systems and show either role how to benefit from an understanding of the other role’s terminology, techniques, and general work approach. 相似文献
102.
Huth J Buchholz M Kraus JM Mølhave K Gradinaru C v Wichert G Gress TM Neumann H Kestler HA 《Computer methods and programs in biomedicine》2011,104(2):227-234
The direct observation of cells over time using time-lapse microscopy can provide deep insights into many important biological processes. Reliable analyses of motility, proliferation, invasive potential or mortality of cells are essential to many studies involving live cell imaging and can aid in biomarker discovery and diagnostic decisions. Given the vast amount of image- and time-series data produced by modern microscopes, automated analysis is a key feature to capitalize the potential of time-lapse imaging devices. To provide fast and reproducible analyses of multiple aspects of cell behaviour, we developed TimeLapseAnalyzer. Apart from general purpose image enhancements and segmentation procedures, this extensible, self-contained, modular cross-platform package provides dedicated modalities for fast and reliable analysis of multi-target cell tracking, scratch wound healing analysis, cell counting and tube formation analysis in high throughput screening of live-cell experiments. TimeLapseAnalyzer is freely available (MATLAB, Open Source) at http://www.informatik.uni-ulm.de/ni/mitarbeiter/HKestler/tla. 相似文献
103.
104.
The speed and reliability of mammalian perception indicate that cortical computations can rely on very few action potentials per involved neuron. Together with the stochasticity of single-spike events in cortex, this appears to imply that large populations of redundant neurons are needed for rapid computations with action potentials. Here we demonstrate that very fast and precise computations can be realized also in small networks of stochastically spiking neurons. We present a generative network model for which we derive biologically plausible algorithms that perform spike-by-spike updates of the neuron's internal states and adaptation of its synaptic weights from maximizing the likelihood of the observed spike patterns. Paradigmatic computational tasks demonstrate the online performance and learning efficiency of our framework. The potential relevance of our approach as a model for cortical computation is discussed. 相似文献
105.
Human eye-head co-ordination in natural exploration 总被引:1,自引:0,他引:1
Einhäuser W Schumann F Bardins S Bartl K Böning G Schneider E König P 《Network (Bristol, England)》2007,18(3):267-297
During natural behavior humans continuously adjust their gaze by moving head and eyes, yielding rich dynamics of the retinal input. Sensory coding models, however, typically assume visual input as smooth or a sequence of static images interleaved by volitional gaze shifts. Are these assumptions valid during free exploration behavior in natural environments? We used an innovative technique to simultaneously record gaze and head movements in humans, who freely explored various environments (forest, train station, apartment). Most movements occur along the cardinal axes, and the predominance of vertical or horizontal movements depends on the environment. Eye and head movements co-occur more frequently than their individual statistics predicts under an independence assumption. The majority of co-occurring movements point in opposite directions, consistent with a gaze-stabilizing role of eye movements. Nevertheless, a substantial fraction of eye movements point in the same direction as co-occurring head movements. Even under the very most conservative assumptions, saccadic eye movements alone cannot account for these synergistic movements. Hence nonsaccadic eye movements that interact synergistically with head movements to adjust gaze cannot be neglected in natural visual input. Natural retinal input is continuously dynamic, and cannot be faithfully modeled as a mere sequence of static frames with interleaved large saccades. 相似文献
106.
Giesen J Mueller K Schuberth E Wang L Zolliker P 《IEEE transactions on visualization and computer graphics》2007,13(6):1664-1671
Visualization algorithms can have a large number of parameters, making the space of possible rendering results rather high-dimensional. Only a systematic analysis of the perceived quality can truly reveal the optimal setting for each such parameter. However, an exhaustive search in which all possible parameter permutations are presented to each user within a study group would be infeasible to conduct. Additional complications may result from possible parameter co-dependencies. Here, we will introduce an efficient user study design and analysis strategy that is geared to cope with this problem. The user feedback is fast and easy to obtain and does not require exhaustive parameter testing. To enable such a framework we have modified a preference measuring methodology, conjoint analysis, that originated in psychology and is now also widely used in market research. We demonstrate our framework by a study that measures the perceived quality in volume rendering within the context of large parameter spaces. 相似文献
107.
Klaus Meer 《Theory of Computing Systems》2007,41(1):107-118
In [10] it was recently shown that
that is the existence of transparent long proofs for
was established. The latter denotes the class of real number decision problems verifiable in polynomial time as introduced
by Blum et al. [6]. The present paper is devoted to the question what impact a potential full real number
theorem
would have on approximation issues in the BSS model of computation. We study two natural optimization problems in the BSS
model. The first, denoted by MAX-QPS, is related to polynomial systems; the other, MAX-q-CAP, deals with algebraic circuits.
Our main results combine the PCP framework over
with approximation issues for these two problems. We also give a negative approximation result for a variant of the MAX-QPS
problem. 相似文献
108.
One of the cornerstones of expert performance in complex domains is the ability to perceive problem situations in terms of
their task-relevant semantic properties. One such class of properties consists of phenomena that are defined in terms of patterns
of change over time, i.e., events. A basic pre-requisite for working towards tools to support event recognition is a method for understanding the events that
expert practitioners find meaningful in a given field of practice. In this article we present the modified unit marking procedure
(mUMP), a technique adapted from work on social perception to facilitate identification of the meaningful phenomena which
observers attend to in a dynamic data array. The mUMP and associated data analysis techniques are presented with examples
from a first of a kind study where they were used to elicit and understand the events practitioners found meaningful in a
scenario from an actual complex work domain.
相似文献
David D. WoodsEmail: |
109.
Braunschweig T Kaserer K Chung JY Bilke S Krizman D Knezevic V Hewitt SM 《Proteomics. Clinical applications》2007,1(3):264-271
Thyroid cancer is the most common endocrine neoplasm with multiple histologic subtypes, each associated with different treatments and outcomes. Differentiating benign neoplasms such as follicular adenomas from malignant entities such as follicular carcinomas and papillary carcinoma can be challenging. To define the proteomic profile of different thyroid tumors, we screened an antibody array of 330 features against five thyroid neoplasms: follicular adenoma, follicular carcinoma, papillary carcinoma, anaplastic carcinoma, and medullary carcinoma as well as normal thyroid epithelium. Eight candidate biomarkers; c-erbB-2, Stat5a, Annexin IV, IL-11, RARα, FGF7, Caspase 9, and phospho-c-myc were identified as differentially expressed on the antibody array, and validated with immunohistochemistry on tissue microarrays, with a total of 144 samples of the same variety of thyroid neoplasms. Analysis revealed c-erbB-2, Annexin IV, and Stat5a have potential clinical utility to differentiate follicular adenoma, follicular carcinoma, and papillary carcinoma from each other. By using an antibody array as a discovery platform and a tissue microarray as a first step in validation on a large number of specimens, we have identified new markers that have potential utility in the diagnosis of thyroid neoplasms. 相似文献
110.
A knowledge-based framework for multimedia adaptation 总被引:4,自引:0,他引:4