Impact of the 1998 Gobi dust event on hospital admissions in the Lower Fraser Valley, British Columbia

The adverse public health impacts of anthropogenically derived particulate matter have been well documented, with measurable increases in both morbidity and mortality rates associated with high particulate matter pollution events. Most current research has focussed on the health impacts of anthropogenically derived particulate matter, and there is a distinct scarcity of literature that examines the role of naturally derived particulate matter and adverse health impacts in the urban context. This study of a Gobi desert dust event in the Greater Vancouver region of British Columbia, Canada, in spring of 1998 provided a unique opportunity to identify the adverse health effects related to naturally derived particulate matter in a large urban setting. Respiratory and cardiac hospitalizations were examined for a three-year period (January 1997 to December 1999), with the Gobi dust event occurring in late April 1998. A meteorological analogue was identified for spring 1997 in order to identify the public health impacts associated with anthropogenically derived particulate matter and those impacts associated with the presence of the Gobi desert dust. Results indicate that this Gobi dust event was not associated with an excess of hospitalizations in the Greater Vancouver region. Peak particulate matter concentrations of Gobi desert dust in the airshed were only associated with an additional one or two hospitalizations per 100,000 population for respiratory and cardiac illnesses, and these increases were not distinguishable from the 'normal' variability in hospitalization rates. Despite high particulate matter concentrations, fine particle size, presence of heavy metals in the dust and extended exposure periods, it appears that the Gobi desert dust event was not associated with significant risk to public health in Greater Vancouver, British Columbia. Therefore it is concluded that naturally derived particulate matter is more benign than particulate matter of anthropogenic origin, and thus poses a low risk to health for the general public.     

The effect of bone drilling on pain in gonarthrosis

Problem doctors are a heterogeneous group, and it is sometimes difficult to determine whether a doctor is incompetent or simply makes repeated mistakes hard to avoid completely under pressure of the clinical work-load. The profession has a small repertoire of informal methods for dealing with situations where a colleague has become a problem. An interview study, carried out in Britain and Sweden, revealed the approaches most commonly used. It also showed that the problem doctor's colleagues often hesitate too long in taking the informal approach that the problem is much more difficult to resolve by the time department heads and administrators become involved.     

Effects of leukocyte depletion on the storage quality of whole blood

BACKGROUND: According to the German Guidelines for Hemotherapy, preoperative autologous blood donations can be stored and transfused as whole blood. In contrast to the storage of blood components, however, storage of whole blood results in deterioration of the biological quality due to contamination with leukocytes and platelets. In this study we examined the influence of prestorage leukocyte depletion on the quality of filtered whole blood donations during storage. MATERIAL AND METHODS: Whole blood was donated by healthy volunteers (n = 14,500 ml, 70 ml CPDA-1) and was filtered using an integrated whole blood filter system (Leukotrap A1, Fa.Pall, Dreieich, Germany). The leukocyte-depleted whole blood units were then stored for up to 49 days. Several hematological and biochemical parameters indicative of the quality of blood donations were determined during storage. RESULTS: Our data indicate a quality of leukocyte-depleted whole blood donations comparable to buffy-coat-free red blood cell units. CONCLUSIONS: The Leukotrap A1 whole blood filter system is an interesting option for hospitals lacking the technical capacity to separate whole blood into components. The clinical suitability remains to be investigated by means of clinical studies.     

Basic fibroblast growth factor and insulinlike growth factor I support the growth of human septal chondrocytes in a serum-free environment

OBJECTIVE: To determine if insulinlike growth factor I (IGF-I) and basic fibroblast growth factor (bFGF), individually or in combination, support the growth and viability of human septal chondrocytes in a serum-free medium (SFM) and a serum-enhanced culture medium. DESIGN: Chondrocytes were recovered from enzymatically digested human septal cartilage and were plated for monolayer culture in a newly developed medium. The medium included Dulbecco modified Eagle medium mixed 1:1 with Ham F12 medium and a supplement of known amounts of 2 growth factors-bFGF (100 ng/mL) and IGF-I (100 ng/mL)-used in combination and separately. RESULTS: The combination of IGF-I and bFGF enhanced chondrocyte growth and maintained a high degree of viability in SFM and 10% fetal calf serum. After an initial lag, the SFM, augmented with both growth factors, produced a comparable number of viable cells (4.25+/-0.31 x 10(4)) to that of the medium with 10% fetal calf serum (4.64+/-0.35 x 10(4)) by the seventh day of the experiment. Combined with the 2 growth factors, 10% fetal calf serum provided the greatest proliferation by the end of the experiment. However, the overall mean cell counts for the IGF-I- and bFGF-enhanced SFM were not statistically different. CONCLUSIONS: The combination of IGF-I and bFGF in a serum-free and a serum-supplemented environment supports the growth and viability of human septal chondrocytes in short-term culture. In an SFM, the results obtained approximate those produced in a medium enhanced with 10% fetal calf serum.     

2D Vector field approximation using linear neighborhoods

We present a vector field approximation for two-dimensional vector fields that preserves their topology and significantly reduces the memory footprint. This approximation is based on a segmentation. The flow within each segmentation region is approximated by an affine linear function. The implementation is driven by four aims: (1) the approximation preserves the original topology; (2) the maximal approximation error is below a user-defined threshold in all regions; (3) the number of regions is as small as possible; and (4) each point has the minimal approximation error. The generation of an optimal solution is computationally infeasible. We discuss this problem and provide a greedy strategy to efficiently compute a sensible segmentation that considers the four aims. Finally, we use the region-wise affine linear approximation to compute a simplified grid for the vector field.     

Fast and Scalable CPU/GPU Collision Detection for Rigid and Deformable Surfaces

We present a new hybrid CPU/GPU collision detection technique for rigid and deformable objects based on spatial subdivision. Our approach efficiently exploits the massive computational capabilities of modern CPUs and GPUs commonly found in off‐the‐shelf computer systems. The algorithm is specifically tailored to be highly scalable on both the CPU and the GPU sides. We can compute discrete and continuous external and self‐collisions of non‐penetrating rigid and deformable objects consisting of many tens of thousands of triangles in a few milliseconds on a modern PC. Our approach is orders of magnitude faster than earlier CPU‐based approaches and up to twice as fast as the most recent GPU‐based techniques.     

Numerical solution of singular ODE eigenvalue problems in electronic structure computations

We put forward a new method for the solution of eigenvalue problems for (systems of) ordinary differential equations, where our main focus is on eigenvalue problems for singular Schrödinger equations arising for example in electronic structure computations. In most established standard methods, the generation of the starting values for the computation of eigenvalues of higher index is a critical issue. Our approach comprises two stages: First we generate rough approximations by a matrix method, which yields several eigenvalues and associated eigenfunctions simultaneously, albeit with moderate accuracy. In a second stage, these approximations are used as starting values for a collocation method which yields approximations of high accuracy efficiently due to an adaptive mesh selection strategy, and additionally provides reliable error estimates. We successfully apply our method to the solution of the quantum mechanical Kepler, Yukawa and the coupled ODE Stark problems.