Pluronic lecithin organogel of 5-aminosalicylic acid for wound healing

5-Aminosalicylic acid (5-ASA) is an aminosalicylate anti-inflammatory drug, which is also known as mesalazine or mesalamine. Currently employed in treating inflammatory bowel disease, ulcerative colitis, inflamed anus or rectum, and maintain remission in Crohn's disease. Evidence from the researchers highlighted its significant re-epithelization in allergic asthma, aphthous, and gastric ulcerative conditions. The objective of the study was to formulate the pluronic lecithin organogel (PLO) containing 5-ASA and evaluate its wound-healing ability in a full thickness excision wound rat model. The data obtained from in silico docking studies revealed 5-ASA is having an affinity towards the transforming growth factor-beta (TGF-β) specifically towards beta1. Among various formulations prepared (F1 to F8), F1, and F6 have shown a maximum in vitro drug release with optimum pH and viscosity. From MTT assay it was found that selected PLO formulations showed no toxicity and enhanced cell proliferation in HaCaT cell lines. In vivo wound-healing studies in albino Wistar rats has revealed that PLO accelerates wound closure and reepithelization to the statistically significant level on day 3 (p?相似文献   

Evidence of low-symmetry phases in pressure-dependent Raman spectroscopic study of BaTiO<Subscript>3</Subscript>

In the earlier pressure-dependent Raman spectroscopic studies, it has been reported that BaTiO₃ undergoes a tetragonal to cubic phase transition above ~ 2 GPa, whereas pressure-dependent X-ray absorption, X-ray diffuse scattering studies and pair distribution function studies have reported the presence of a low-symmetry rhombohedral phase above ~ 2.3 GPa. In this report, we present our pressure-dependent Raman spectroscopic studies on polycrystalline BaTiO₃ which shows that it first undergoes a transition from tetragonal to orthorhombic/rhombohedral phase above ~ 2.6 GPa and then finally goes to the cubic phase above 8.4 GPa. Pressure-dependent synchrotron X-ray diffraction (SXRD) studies have also been carried out that provided rate of change of volume as a function of pressure resulting in bulk modulus of 215 ± 9 GPa.     

New exact solutions of the coupled sine-Gordon equations in nonlinear optics using the modified Kudryashov method

The main aim of this article is studying the coupled sine-Gordon equations in nonlinear optics, which describe the propagation of an optical pulse in fibre waveguide. New exact solutions of the coupled sine-Gordon equations have been derived through the use of the well-organized modified Kudryashov method.     

Wave packet enriched finite element for generalized thermoelasticity theories for thermal shock wave problems

A unified enriched finite element (FE) formulation for two generalized thermoelsaticity theories is developed for the transient thermal shock problems in one and two dimensional domains. Both the displacement and temperature field interpolations are enriched with harmonic functions defined in the local element coordinates. The coupled field finite element equations are derived using the generalized Hamilton’s principle and solved directly in time domain using the standard Newmark-β time integration technique as opposed to the transform techniques usually adopted for thermal shock problems. The method is assessed in comparison with the Laplace transform based analytical solutions and FE solutions with dynamic meshing available in the literature. It is shown that the present solution with a static uniform mesh captures the sharp discontinuities in the temperature and displacement fields and the wave properties of heat conduction very accurately, practically eliminating the severe drawbacks of the conventional FE solutions such as the spurious undulations and flattening out, while maintaining better computational e?ciency.     

Physical Effects of Variable Thermophysical Fluid Properties on Flow and Thermal Development in Micro-Channel

Micro-scale cooling is an efficient and effective cooling technique to achieve the goal of higher heat removal capabilities. The present research focuses to find the physical effects of fluid property variations on flow and thermal development in micro-channel. The effects of temperature-dependent density, viscosity, and thermal conductivity variations on single-phase laminar forced convection are numerically investigated. The problem is especially simulated for hydrodynamically and thermally developing water flow in micro-channel with no-slip, no-temperature jump, and constant wall heat flux boundary conditions. It is observed that the density variation induces radially inward flow due to continuity, which sharpens the axial velocity profile and decreases Nusselt number compared to constant property solution. The axial velocity profile significantly alters due to viscosity variation. This alteration varies along the micro-flow and it induces radially flow due to flow continuity. The reducing rate of Nusselt number for viscosity variation is substantially lower than constant property solution due to a significant flattening effect of the axial velocity profile, which augments the Nusselt number. Thermal-conductivity variation across the flow induces radial conduction, which enhances convection compared to constant property solution. Additionally, the effects of thermophysical fluid property variations on static gauge pressure drop are also investigated.     

Role of weave design on the mechanical properties of 3D woven fabrics as reinforcements for structural composites

3D fabrics as reinforcement can be manipulated in discrete numbers of weave designs in order to earn maximum gain so that the desired mechanical properties of the composites can be achieved eventually for particular end use. Thus interest has been focused to investigate tensile, impact and knife penetration properties of 3D orthogonal and interlock structures of different weave designs by varying their binder interlacement patterns keeping stuffer binder ratio constant. The tensile properties were effectively influenced by the linear densities as well as crimp of load bearing tows, which were determined by the weave design of the fabric. The compact structure generated from regular weave pattern in case of 1 × 1 plain orthogonal and 1 × 1 plain interlock fabrics exhibited better impact energy absorption. Owing to higher values of peak energy in the knife penetration test, it is revealed that more is the number of fibres in the in-plane direction better is the protection.     

Land surface deformation parameter estimation using persistent scatterer interferometry approach in an underground metal mining environment

Persistent scatterer interferometry (PSI) is a major advancement in radar interferometry for detecting and monitoring land deformation. PSI is the most advanced class of differential interferometric synthetic aperture radar (DInSAR) techniques. The technique conquers the main drawbacks of the conventional DInSAR technique by identifying radar targets having stable backscattering characteristics in time. These targets are termed as persistent scatterers (PSs). The higher the number of PSs for a study area the higher the accuracy of the results will be, which is most common for deformation analysis in urban areas. However, for non-urban or highly de-correlated areas, PSs density collapses significantly, which needs to increase for optimal results. For this purpose, partially coherent/distributed scatterers (DSs) are being exploited in addition to the PSs. The field surface of this study is one of the copper-rich mining belts in India, which consists of two major underground metal mines. Scatterer characterziation of the field surface under study suggests that most of the scatterers are DSs and very few scatterers under the influence of the mining zone are PSs. In addition to this, a preliminary investigation of deformation characteristics of the field surface under study reveals that the spatial extent of deformation is small/localized along with slow and non-linear deformation. Keeping in view scatterer and deformation characteristics of the field surface under study, in this research paper, a Quasi-Persistent Scatterer based PSI approach has been applied using high-resolution TerraSAR-X interferometric data stack (10 images) to generate deformation time series and deformation velocity. Furthermore, results obtained from the applied PSI approach and ground-based observations (using GNSS) have shown good agreement with each other, in the order of ?5.20?mm/year (LOS) and ?5.38?mm/year (subsiding), respectively.     

Correction to: Comparative analysis of limit equilibrium and numerical methods for prediction of a landslide

Bulletin of Engineering Geology and the Environment - Landslides that occur due to the rapid motion of a rock-mass are a primary risk in mountainous terrains and are a danger to human life and...     

Impulse Pressure Assisted Diffusion Bonding of Low Carbon Steel Using Silver Interlayer

In the present study, impulse pressure assisted diffusion bonding of low carbon steel was carried out using silver interlayer. To study the influence of input process parameters namely bonding temperature (T), maximum pulse pressure (P), and number of pulses (N), experiments of diffusion bonding were conducted according to the Taguchi L9 orthogonal array. To reveal the typical bond interface characteristics, selected samples were examined by scanning electron microscopy (FESEM) equipped with energy dispersive spectroscopy (EDS). The EDS analysis revealed a diffusion affected zone at the interface due to the diffusion of silver and iron across the interface. Lap joints were developed to measure the shear strength of the diffusion bonds. The optimum level of bonding temperature, maximum pulse pressure and number of pulses (875 °C, 10 MPa and 10 pulses) were identified. The ANOVA results indicated that bonding temperature had the highest statistical effect of 66.37% on shear strength followed by number of pulses and maximum pulse pressure. The fracture surface of the lap joints was also examined by FESEM and X-ray diffraction analysis.