Design and synthesis of non-steroidal diclofenac derivatives as anti-inflammatory drugs

In the course of our studies directed towards the discovery of novel non-steroidal anti-inflammatory agents (NSAIDs), which are expected to have improved drug efficacy and better toxicity profile than diclofenac, we have synthesized new derivatives of diclofenac phosphonates. These phosphonate analogs were efficiently prepared from commercially available 2-hydroxymethylaniline in three steps. The 2-hydroxymethylaniline was converted to the azide in reasonable yield. Click chemistry with a variety of alkynes followed by Arbuzov reaction resulted in a series of triazole based phosphonate products. Our inhibitors are designed to reduce the gastrointestinal bleeding caused by diclofenac by substituting the carboxylic acid group with the phosphonate group and in addition replacing with the triazole ring would allow the flexibility to explore the importance of both hydrophilicity and hydrophobicity of the ring at the active site.     

Heat exchange during a slow flow of a liquid between coaxial conical surfaces

The problem of convective heat transfer during a slow liquid flow in conical annular channels is considered. For third-kind thermal boundary conditions, the problem is solved by separation of variables. The temperature distribution is represented as the product of an infinite Whittaker-function series in lateral coordinate and an exponential of longitudinal coordinate. Heat transfer in a variable-width annular conical channel is analyzed by stepwise approximation. Optimization of the distributing sections of extruder dies is shown to be possible.     

The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model

In our previous study, we revealed the ameliorative therapeutic effect of dexamethasone (Dex) for Lupus nephritis lesions in the MRL/MpJ-Fas ^lpr/lpr (Lpr) mouse model. The female Lpr mice developed a greater number of mediastinal fat-associated lymphoid clusters (MFALCs) and inflammatory lung lesions compared to the male mice. However, the effect of Dex, an immunosuppressive drug, on both lung lesions and the development of MFALCs in Lpr mice has not been identified yet. Therefore, in this study, we compared the development of lung lesions and MFALCs in female Lpr mice that received either saline (saline group “SG”) or dexamethasone (dexamethasone group “DG”) in drinking water as a daily dose along with weekly intraperitoneal injections for 10 weeks. Compared to the SG group, the DG group showed a significant reduction in the levels of serum anti-dsDNA antibodies, the size of MFALCs, the degree of lung injury, the area of high endothelial venules (HEVs), and the number of proliferating and immune cells in both MFALCs and the lungs. A significant positive correlation was observed between the size of MFALCs and the cellular aggregation in the lungs of Lpr mice. Therefore, this study confirmed the ameliorative effect of Dex on the development of lung injury and MFALCs via their regressive effect on both immune cells’ proliferative activity and the development of HEVs. Furthermore, the reprogramming of MFALCs by targeting immune cells and HEVs may provide a therapeutic strategy for autoimmune-disease-associated lung injury.     

Using equidistant vector-based hysteresis current regulators in DFIG wind generation systems

This paper proposes a novel equidistant vector-based hysteresis current regulator (VBHCR) in the rotor-side converter (RSC) of DFIG-based wind generation systems. The Γ-form equivalent circuit is used for the machine modelling, with the discrete formulation of the RSC output voltage. The overall vector control scheme is then explored and the control structure of the proposed equidistant VBHCR is presented. When compared to the commonly used PI current regulators, the proposed VBHCR exhibits several advantages such as very fast transient response, simple hardware implementation, satisfactory steady-state performance, and intrinsic robustness to machine parameters variations. Moreover, fixed hysteresis bands are replaced with equidistant bands in order to limit the instantaneous variations of the switching frequency and reduce the maximum switching frequency of the RSC. Detailed simulation studies are carried out for a 1.5 MW DFIG-based wind generator to examine the operation of the proposed current regulator under various operating conditions and demonstrate its superiority over the standard PI current regulator.     

Data-driven next-generation smart grid towards sustainable energy evolution: techniques and technology review

Meteorological changes urge engineering communities to look for sustainable and clean energy technologies to keep the environment safe by reducing CO2 emissions. The structure of these technologies relies on the deep integration of advanced data-driven techniques which can ensure efcient energy generation, transmission, and distribution. After conducting thorough research for more than a decade, the concept of the smart grid (SG) has emerged, and its practice around the world paves the ways for efcient use of reliable energy technology. However, many developing features evoke keen interest and their improvements can be regarded as the next-generation smart grid (NGSG). Also, to deal with the non-linearity and uncertainty, the emergence of data-driven NGSG technology can become a great initiative to reduce the diverse impact of non-linearity. This paper exhibits the conceptual framework of NGSG by enabling some intelligent technical features to ensure its reliable operation, including intelligent control, agent-based energy conversion, edge computing for energy management, internet of things (IoT) enabled inverter, agent-oriented demand side management, etc. Also, a study on the development of data-driven NGSG is discussed to facilitate the use of emerging data-driven techniques (DDTs) for the sustainable operation of the SG. The prospects of DDTs in the NGSG and their adaptation challenges in real-time are also explored in this paper from various points of view including engineering, technology, et al. Finally, the trends of DDTs towards securing sustainable and clean energy evolution from the NGSG technology in order to keep the environment safe is also studied, while some major future issues are highlighted. This paper can ofer extended support for engineers and researchers in the context of data-driven technology and the SG.     

Effect of Paralleling the Stator Coils in a Permanent-Magnet Machine

As low-voltage machines require smaller number of turns per phase compared to higher voltage machines, it is normal to connect the various stator phase coils in parallel to form the phase winding. The placement of various coil sides in the slot and the difference in the field produced by different poles of the rotor magnet can influence the induced voltage in various coils and the impedance of the coils. The difference in the induced voltages in the various parallel paths results in a circulating current in the winding and will cause increased losses in the machine. The unequal induced voltage and impedance will cause unequal distribution of stator current in the various parallel paths and will impact the torque-ripple contents. This paper will discuss the effects of these unbalanced parallel paths on the machine performance     

Modeling resistive switching materials and devices across scales

Resistance switching devices based on electrochemical processes have attractive significant attention in the field of nanoelectronics due to the possibility of switching in nanosecond timescales, miniaturization to tens of nanometer and multi-bit storage. Their deceptively simple structures (metal-insulator-metal stack) hide a set of complex, coupled, processes that govern their operation, from electrochemical reactions at interfaces, diffusion and aggregation of ionic species, to electron and hole trapping and Joule heating. A combination of experiments and modeling efforts are contributing to a fundamental understanding of these devices, and progress towards a predictive understanding of their operation is opening the possibility for the rational optimization. In this paper we review recent progress in modeling resistive switching devices at multiple scales; we briefly describe simulation tools appropriate at each scale and the key insight that has been derived from them. Starting with ab initio electronic structure simulations that provide an understanding of the mechanisms of operation of valence change devices pointing to the importance of the aggregation of oxygen vacancies in resistance switching and how dopants affect performance. At slightly larger scales we describe reactive molecular dynamics simulations of the operation of electrochemical metallization cells. Here the dynamical simulations provide an atomic picture of the mechanisms behind the electrochemical formation and stabilization of conductive metallic filaments that provide a low-resistance path for electronic conduction. Kinetic Monte Carlo simulations are one step higher in the multiscale ladder and enable larger scale simulations and longer times, enabling, for example, the study of variability in switching speed and resistance. Finally, we discuss physics-based simulations that accurately capture subtleties of device behavior and that can be incorporated in circuit simulations.     

Raman amplifiers for telecommunications

Raman amplifiers are being deployed in almost every new long-haul and ultralong-haul fiber-optic transmission systems, making them one of the first widely commercialized nonlinear optical devices in telecommunications. This paper reviews some of the technical reasons behind the wide-spread acceptance of Raman technology. Distributed Raman amplifiers improve the noise figure and reduce the nonlinear penalty of fiber systems, allowing for longer amplifier spans, higher bit rates, closer channel spacing, and operation near the zero-dispersion wavelength. Lumped or discrete Raman amplifiers are primarily used to increase the capacity of fiber-optic networks, opening up new wavelength windows for wavelength-division multiplexing such as the 1300 nm, 1400 nm, or short-wavelength S-band. As an example, using a cascade of S-band lumped amplifiers, a 20-channel, OC-192 system is shown that propagates over 867 km of standard, single-mode fiber. Raman amplifiers provide a simple single platform for long-haul and ultralong-haul amplifier needs and, therefore, should see a wide range of deployment in the next few years     

Effect of Channel Width Variation on Electrical Characteristics of Double Lateral Gate Junctionless Transistors; A Numerical Study

In this paper, the effect of channel width variation on performance of double lateral gate junctionless transistors in the depletion and accumulation regimes is investigated. The characteristics of the device with various channel widths is comprehensively examined through analysis of on and off state current, threshold voltage (V _th), transconductance (g _m) and drain conductance (g _D) variation in each operating regime. The carriers’ density distribution, electric field components and mobility are investigated through 3-D numerical simulations of the device to illustrate the variation of output characteristics. The results show that as the width decreases, the off-current (I _OFF) decreases significantly as a result of better electrostatic control of the lateral gates over the channel. The on-current (I _ON) is also decreased mainly due to the doping-dependent mobility degradation.It is also indicated that between the flat-band and fully depleted (pinch off) variation of the majority carriers is the main parameter that modifies the characteristics of the device, while the mobility variation is recognized as the basic factor in the accumulation regime.     

Generation of Hypervelocity Particle Flows by Explosive Compression of Ceramic Tubes

The compression of ceramic (corundum) tubes by the detonation products of explosives have been studied experimentally and numerically. The formation of the shaped-charge jet of ceramic particles and its effect on steel witnesses targets has been investigated. The tubes were produced by detonation spraying. Ceramic particles were deposited on copper tubes, which were then dissolved in a solution of ferric chloride. In the experiments, a considerable penetration of the flow of ceramic particles was observed. During the interaction of the flow with the target, the target material was partially evaporated, as shown by metallographic analysis. Numerical analysis of the formation of the discrete shaped-charge jet showed that the maximum velocity of the jet head was about 23 km/s, and the velocity of the main part of the jet was about 14 km/s.