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11.
Hahlweg Kurt; Markman Howard J.; Thurmaier Franz; Engl Jochen; Eckert Volker 《Canadian Metallurgical Quarterly》1998,12(4):543
This article reports on the development and long-term evaluation of a marital distress prevention program for German couples, the Ein Partnerschaftliches Lernprogramm (EPL, A Couple's Learning Program). The EPL is a 6-session program designed to teach couples effective communication and problem-solving skills. In the current article, the EPL is evaluated in a prospective, quasi-experimental, controlled trial. The results of the 3-year follow-up are reported, contrasting 55 EPL couples with a control group of 17 couples. Significant differences emerged with regard to the couples' dissolution rates, relationship satisfaction, and positive and negative communication behavior favoring the EPL couples. These results demonstrate the utility of the EPL program in assisting happy couples who are preparing for marriage. The implications of the findings for prevention research and for the dissemination of prevention programs are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
12.
Rodrigo F. Ortiz-Meoz Liping Wang Rosalie Matico Anna Rutkowska-Klute Martha De la Rosa Sabrina Bedard Robert Midgett Katrin Strohmer Douglas Thomson Cunyu Zhang Makda Mebrahtu Jeffrey Guss Rachel Totoritis Thomas Consler Nino Campobasso David Taylor Tia Lewis Kurt Weaver Marcel Muelbaier John Seal Richard Dunham Wieslaw Kazmierski David Favre Giovanna Bergamini Lisa Shewchuk Alan Rendina Guofeng Zhang 《Chembiochem : a European journal of chemical biology》2021,22(3):516-522
Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the rate-limiting step in the kynurenine pathway of tryptophan (TRP) metabolism. As it is an inflammation-induced immunoregulatory enzyme, pharmacological inhibition of IDO1 activity is currently being pursued as a potential therapeutic tool for the treatment of cancer and other disease states. As such, a detailed understanding of the mechanism of action of IDO1 inhibitors with various mechanisms of inhibition is of great interest. Comparison of an apo-form-binding IDO1 inhibitor (GSK5628) to the heme-coordinating compound, epacadostat (Incyte), allows us to explore the details of the apo-binding inhibition of IDO1. Herein, we demonstrate that GSK5628 inhibits IDO1 by competing with heme for binding to a heme-free conformation of the enzyme (apo-IDO1), whereas epacadostat coordinates its binding with the iron atom of the IDO1 heme cofactor. Comparison of these two compounds in cellular systems reveals a long-lasting inhibitory effect of GSK5628, previously undescribed for other known IDO1 inhibitors. Detailed characterization of this apo-binding mechanism for IDO1 inhibition might help design superior inhibitors or could confer a unique competitive advantage over other IDO1 inhibitors vis-à-vis specificity and pharmacokinetic parameters. 相似文献
13.
Stefan Kühne Kurt Haskic Stephanie Lemke Martin Schmidt 《Microsystem Technologies》2014,20(10-11):2103-2107
The production of three dimensional blazed grating structures based on ultra-precision machining is an up-to-date issue. Hence, in the development of manufacturing technologies technology-related failure modes are generated due to structural variations. These failure errors must be recorded in cause and effect and then characterized by their type in order to achieve the optimum quality. This paper addresses the influence of processing parameters on the shape-persistence and hence on the grating quality and explains the possibility of detection and classification of them. 相似文献
14.
Communication is a key success factor of distributed software projects. Poor communication has been identified as a main obstacle to successful collaboration. Global projects are especially endangered by information gaps between collaborating sites. Different communication styles, technical equipment, and missing awareness of each other can cause severe problems. Knowledge about actual and desired channels, paths, and modes of communication is required for improving communication in a globally distributed project. However, many project participants know little about communication and information flow in their projects. In this contribution, we focus on knowledge about communication and information flow. It is acquired by modelling on‐going and desired flows of information, including documented and non‐documented channels of information flow. We analyzed a distributed software project from the information flow perspective. Based on the findings, we developed specific techniques to improve information flow in distributed software development according to the FLOW Method. In a second distributed project, we evaluated one of the techniques. We found the FLOW mapping technique to be suitable for effectively spreading knowledge about communication and information flow in global software projects. 相似文献
15.
The solubility of propane in sulpholane has been determined at temperatures in the range 298‐403 K at pressures up to 17.6 MPa. The experimental results were correlated by the Peng‐Robinson equation of state, and binary interaction parameters have been obtained for this system. The parameters in the Krichevsky‐Ilinskaya equation were calculated from these interaction parameters. 相似文献
16.
Wolff RL Lavialle O Pédrono F Pasquier E Destaillats F Marpeau AM Angers P Aitzetmüller K 《Lipids》2002,37(1):17-26
The seed fatty acid (FA) compositions of Abietoids (Abies, Cedrus, Hesperopeuce, Keteleeria, Pseudolarix, and Tsuga) are reviewed in the present study in conclusion to our survey of Pinaceae seed FA compositions. Many unpublished data are
given. Abietoids and Pinoids (Pinus, Larix, Ficea, and Pseudotsuga)—constituting the family Pinaceae—are united by the presence of several Δ5-olefinic acids, taxoleic (5,9–18∶2), pinolenic
(5,9,12–18∶3) coniferonic (5,9,12,15–18∶4), keteleeronic (5,11–20∶2), and sciadonic (5,11,14–20∶3) acids, and of 14-methyl
hexadecanoic (anteiso-17∶0) acid. These acids seldom occur in angiosperm seeds. The proportions of individual Δ5-olefinic
acids, however, differ between Pinoids and Abietoids. In the first group, pinolenic acid is much greater than taxoleic acid,
whereas in the second group, pinolenic acid is greater than or equal to taxoleic acid. Moreover, taxoleic acid in Abietoids
is much greater than taxoleic acid in Pinoids, an apparent limit between the two subfamilies being about 4.5% of that acid
relative to total FA. Tsuga spp. appear to be a major exception, as their seed FA compositions are much like those of species from the Pinoid group.
In this respect, Hesperopeuce mertensiana, also known as Tsuga mertensiana, has little in common with Abietoids and fits the general FA pattern of Pinoids well. Tsuga spp. and H. mertensiana, from their seed FA compositions, should perhaps be separated from the Abietoid group and their taxonomic position revised.
It is suggested that a “Tsugoid” subfamily be created, with seed FA in compliance with the Pinoid pattern and other botanical
and immunological criteria of the Abietoid type. All Pinaceae genera, with the exception of Pinus, are quite homogeneous when considering their overall seed FA compositions, including Δ5-olefinic acids. In all cases but
one (Pinus), variations from one species to another inside a given genus are of small amplitude. Pinus spp., on the other hand, have highly variable levels of Δ5-olefinic acids in their FA compositions, particularly when sections
(e.g., Cembroides vs. Pinus sections) or subsections (e.g., Flexiles and Cembrae subsections from the section Strobus) are compared, although they show qualitatively the same FA patterns characteristic of Pinoids. Multicomponent analysis of
Abietoid seed FA allowed grouping of individual species into genera that coincide with the same genera otherwise characterized
by more classical botanical criteria. Our studies exemplify how seed FA compositions, particularly owing to the presence of
Δ5-olefinic acids, may be useful in sustaining and adding some precision to existing taxonomy of the major family of gymnosperms,
Pinaceae. 相似文献
17.
18.
Matthias Berger Kurt Laumen Manfred P. Schneider 《Journal of the American Oil Chemists' Society》1992,69(10):955-960
Regioisomerically pure 1,3-sn-diacylglycerols are conveniently prepared in high yields (>80%) and in large quantities by enzymatic esterification of glycerol
in the presence of various 1,3-selective lipases(Chromobacterium viscosum, Rhizopus delemar, Rhizomucor miehei) and a variety of different acyl donors like free fatty acids, fatty acid alkyl esters and vinyl esters. All reactions are
carried out in aprotic organic solvents of low water content, namelyn-hexane, diethyl ether or tBuOMe. The creation of an artificial interphase between the solvent-immiscible hydrophilic glycerol
and the hydrophobic reaction media by the adsorption of glycerol onto a solid support prior to use was essential for the success
of these transformations. The effects of reaction conditions and the regioselectivities of the lipases on the product yields
are described in detail. 相似文献
19.
Bhikhu Suthar Daniel Klempner Kurt C. Frisch Zoran Petrovic Zelimir Jelcic 《应用聚合物科学杂志》1994,53(8):1083-1090
Three series of interpenetrating polymer networks (IPNs) based on a polyurethane (castor oil + toluene diisocyanate) with polystyrene, poly(methyl methacrylate), and poly(n-butyl methacrylate) were synthesized and characterized. Dielectric relaxation studies of these IPNs were carried out from ?150 to 100°C in the 100 Hz to 100 kHz range. The effects of structural variables such as composition, type of vinyl monomer, as well as the effect of interaction of the phases on the dielectric properties were studied. A certain degree of phase mixing was observed to exist in all series as detected by the variation of the glass-transition temperatures of the IPNs. Maxwell–Wagner–Sillars polarization at the interface of the two phases was observed. © 1994 John Wiley & Sons, Inc. 相似文献
20.