Static Strategies for Worksharing with Unrecoverable Interruptions

One has a large workload that is “divisible”—its constituent work’s granularity can be adjusted arbitrarily—and one has access to p remote worker computers that can assist in computing the workload. How can one best utilize the workers? Complicating this question is the fact that each worker is subject to interruptions (of known likelihood) that kill all work in progress on it. One wishes to orchestrate sharing the workload with the workers in a way that maximizes the expected amount of work completed. Strategies are presented for achieving this goal, by balancing the desire to checkpoint often—thereby decreasing the amount of vulnerable work at any point—vs. the desire to avoid the context-switching required to checkpoint. Schedules must also temper the desire to replicate work, because such replication diminishes the effective remote workforce. The current study demonstrates the accessibility of strategies that provably maximize the expected amount of work when there is only one worker (the case p=1) and, at least in an asymptotic sense, when there are two workers (the case p=2); but the study strongly suggests the intractability of exact maximization for p≥2 computers, as work replication on multiple workers joins checkpointing as a vehicle for decreasing the impact of work-killing interruptions. We respond to that challenge by developing efficient heuristics that employ both checkpointing and work replication as mechanisms for decreasing the impact of work-killing interruptions. The quality of these heuristics, in expected amount of work completed, is assessed through exhaustive simulations that use both idealized models and actual trace data.     

Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by unexplained physical fatigue, cognitive and sensory dysfunction, sleeping disturbances, orthostatic intolerance, and gastrointestinal problems. People with ME/CFS often report a prodrome consistent with infections. Using regression, Bayesian and enrichment analyses, we conducted targeted and untargeted metabolomic analysis of plasma from 106 ME/CFS cases and 91 frequency-matched healthy controls. Subjects in the ME/CFS group had significantly decreased levels of plasmalogens and phospholipid ethers (p < 0.001), phosphatidylcholines (p < 0.001) and sphingomyelins (p < 0.001), and elevated levels of dicarboxylic acids (p = 0.013). Using machine learning algorithms, we were able to differentiate ME/CFS or subgroups of ME/CFS from controls with area under the receiver operating characteristic curve (AUC) values up to 0.873. Our findings provide the first metabolomic evidence of peroxisomal dysfunction, and are consistent with dysregulation of lipid remodeling and the tricarboxylic acid cycle. These findings, if validated in other cohorts, could provide new insights into the pathogenesis of ME/CFS and highlight the potential use of the plasma metabolome as a source of biomarkers for the disease.     

双压板轴向夹紧夹具

针对文献中多次装夹、弹性心轴定位、软爪径向夹持等夹具不能解决高精度管壳工件装夹变形的问题,提出了双压板夹紧夹具,一次装夹工件,通过换压板端面形式,将管壳工件外圆、内孔、端面一次加工成型。多批次薄壁管壳工件的加工表明达到保证工件的外圆、孔、端面的形位公差要求,消除了径向夹紧变形。     

Catalytic wall reactor: Catalytic coatings of stainless steel by VOx/TiO2 and Co/SiO2 catalysts

Catalytic wall (structured) reactors and structured supports are suitable to study the catalytic properties of nanosized materials. The coating of metallic (aluminum and stainless steel) plates by thin layers of active phase is presented in two cases, VO_x/TiO₂ and Co/SiO₂, catalysts used in the oxidative dehydrogenation (ODH) of propane and in Fischer–Tropsch synthesis (FTS) of clean fuels, respectively. The preparation of coated plates and their characterisation by various methods of physicochemical analysis are described. Both chemical and physical methods were used for coating. VO_x/TiO₂ layers were obtained by grafting of Ti (on Al or stainless-steel plates) and V (on TiO₂) alkoxides and use of sol–gel media or suspension. A silica primer was deposited (on stainless-steel plate) by plasma-assisted chemical vapour deposition (PACVD) onto which Co oxide and silica were coprecipitated from sol–gel. The catalytic experiments in the respective reactions were carried out in special plate reactors and compared with those of catalytic powders. The study shows that the coating of a metallic substrate by a catalyst is not straightforward and requires specific studies dealing with both chemistry (chemical affinity between substrate and catalytic layers) and catalytic engineering (catalytic performance in taylor-made reactors).     

Enhanced deep-joint segmentation with deep learning networks of glioma tumor for multi-grade classification using MR images

Pattern Analysis and Applications - The crucial imaging modality employed in medicinal diagnostic tools to detect the tumors is magnetic resonance image (MRI). Based on the glioma anatomical...     

Effect of temperature and pH on the post-mortem degradation of myofibrillar proteins

Incubation of bovine muscle at 37°C promoted a more drastic proteolytic change in myofibrillar proteins, as determined from sodium dodecyl sulphate polyacrylamide gels of isolated myofibrils, than incubation at 4°C. Degradation of myosin and troponin-T were the most noticeable changes at 37°C. Loss of α-actinin was observed in the 4°C incubated muscle. Ground bovine muscle incubated at pH 5·4 and 7 revealed that alterations in myosin and troponin-T were the most noticeable changes at ph 5·4 while troponin-T and α-actinin were altered at pH7. More troponin-T degradation occurred at pH 5·4 and 37°C than at pH7 and 4°C (similar to the degradation of myosin), indicating that troponin-T degradation in post-mortem muscle may be an indicator of overall myofibrillar proteolysis and not responsible for post-mortem tenderisation per se. Myosin degradation in the ground samples incubated at pH 5·4 and in whole samples incubated at 37°C was compared with the digestion of myofibrillar myosin by papain. Both pyrophosphate and Guba-Straub extracts of the 37°C and pH 5·4 treated samples confirmed that myosin degradation did occur to a much greater extent at this temperature and pH than at 4°C and pH7, and, in addition, at pH 5·4 frequent cleavage occurred near the papain sensitive site of myosin.     

Radiation shielding of spacecraft in manned interplanetary flights.

During the interplanetary flights the crewmembers will be exposed to cosmic ray radiation with great risk for their health. The absorbed dose due to CR depends on the galactic (GCR) or solar (SCR) origin. GCRs are isotropic and relatively high in energy and deliver a dose nearly constant with time that can be reduced only by means of "heavy" passive protection. The outer walls of the spacecraft usually shield the SCRs up to a few tens of MeV, but during some exceptional solar bursts, a great number of particles, mainly protons, are ejected at higher energies. In this case the dose delivered in a few hours by a solar burst can easily exceed 1 year cumulated dose by GCRS. The high-energy component of SCRs is quasi-directional so that a shielding system based on a superconductive magnetic lens can reduce the daily dose of SCRs to the level delivered by GCRS.     

Urocanic acid enhances IL-10 production in activated CD4+ T cells

The immunosuppressive effects of UV radiation have been well documented. This suppression has been attributed to the action of the cis form of urocanic acid (UCA), a photoproduct of trans-UCA, a natural constituent of the skin. Here, we show that mouse spleen cells preincubated with cis-UCA have a diminished proliferative response to allogeneic cells in MLC and to stimulation with anti-CD3 mAb. Cells preincubated with cis-UCA also had a decreased ability to serve as APC and to stimulate the proliferation of allogeneic lymphocytes in MLC. Simultaneously, the production of IL-2 and IFN-gamma by cells preincubated with cis-UCA was decreased. However, IL-10 gene expression and IL-10 protein secretion by spleen cells stimulated in the presence of cis-UCA were significantly enhanced. The principal cell population displaying the cis-UCA-induced elevated production of IL-10 was CD4+ T cells, which were shown to be a direct target of cis-UCA action. This was also supported by the observation that production of IL-10 by stimulated splenic non-T cells or by macrophages was not altered by cis-UCA. The enhanced production of IL-10 by activated CD4+ T cells may represent a novel pathway of UVB radiation-induced, cis-UCA-mediated immunosuppression. We suggest that the elevated production of IL-10 by activated CD4+ T cells may account for the suppressor T cell phenomena described in UV-irradiated recipients.     

Determination of Fracture Toughness of Underfill/Chip Interface With Digital Image Speckle Correlation Technique

The layered packages are prone to multimode damages and failures when they are subjected to complicated and coupling environmental loading. As a result, fracture toughness is usually used as a fracture criterion to evaluate the reliability of polymer/inorganic interface. In this study, an in-situ/real-time micro-digital image speckle correlation (mu-DiSC) system was established and employed to determine the fracture toughness of underfill/chip interface involved in flip chip assembly. The tests were carried out over a wide range of temperatures and at various loading angles. In order to verify the finding of the mu-DiSC technique, an interface fracture mechanics based finite element model is implemented into ANSYS to calculate the values of crack-tip opening displacement of underfill/chip joint under different loading configurations. The results obtained from the simulation are found to be in good agreement with those measured by the mu-DiSC system, indicating that the system can be used as an accurate and effective experimental tool for the electronic packages. The fractographs, with respect to different temperatures and loading angles, are further discussed     

Estimation of X-band scattering properties of treecomponents

An X-band FM-CW very-fine-range resolution scatterometer was used to acquire backscattering data for individual branches for a number of tree species. Using a model to describe the scattering source function and an experimental procedure for selected removal of plant parts, an estimation was made of η, the volume backscatter coefficient, and κ, the volume extinction coefficient. It is found that: (1) leaves are strong attenuators as well as scatterers; (2) the albedo (the ratio η/κ), at a given angle of incidence, is nearly independent of the tree type; (3) the tree limbs are good attenuators but rather poor scatterers; and (4) te albedo changes as a function of the angle of incidence and for deciduous trees is also a function of the season