Discriminating age-associated memory impairment from Alzheimer's disease.

The authors attempt to provide a better understanding of the differences between the normal memory decline characteristic of age-associated memory impairment (AAMI) and the pathological decline typical of mild Alzheimer's disease (AD). Batteries of traditional memory tests and computer-simulated everyday-memory tests discriminated between the 2 groups, which were matched on age, gender, and education, with reasonable degrees of accuracy (87.5% and 88.4%, respectively). False positives were the most frequent classification errors when using either battery. These results indicate that it is possible to use ecologically valid memory assessment paradigms without sacrificing discriminant validity. The clinical significance of discriminating mild AD from AAMI is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

2,4-Dichlorophenoxyacetic acid action on in vitro protein synthesis and its relation to polyamines

The effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on the in vitro synthesis of proteins was studied in Chinese hamster ovary cells. A remarkable inhibition of the synthesis of proteins was observed when cells grew for 24 h in presence of 1 mM 2,4-D. This effect was reversed by adding 0.1 mM of the three polyamines (putrescine, spermidine and spermine) to the cultured cells. The mRNA is not altered, indicating that the 2,4-D action is located at a different locus, which may be the ribosomes. From these studies, one can speculate that the alterations in the protein synthesis may be a consequence of the effect of 2,4-D on the polyamine metabolism.     

Properties of titanium-containing sol-gel films modified with copper and vanadium oxides

Translated from Steklo i Keramika, No. 1, pp. 4–6, January, 1994.     

Worm plots

Scientists sometimes spend hours conducting experiments only to find that the resulting data proves difficult to analyze with traditional visualization techniques. A typical laboratory experiment, for example, will setup several systems in each of two or more groups-a control group and various treatment groups. The investigator will then measure various parameters for each system over time (sometimes dozens to hundreds of parameters). The investigator tries to answer this question: What is different between the control and treatment groups? Field monitoring of polluted and unpolluted sites within a region result in the same kinds of data and the same difficulties in visualization. Plotting multiple lines on a single 2D plot quickly gets confusing. Plus, the dynamic interactions between parameters can be hard to see. 3D visualizations help researchers make qualitative insights about data more easily. We developed a 3D plotting technique, called “worm plots”, for visualizing these kinds of data. Our visualization tool examines how groups of points change over time. If we plot circles for each time slice, then these circles will change their relative sizes and positions as time goes by. To visualize these evolving dynamics, we connect these time slices with conic sections. This gives us spacetime worms that can be displayed graphically. In our experience, these simple circular cross sections work best when exploring data. They can be rendered quickly and give an easily intuited summary of each group. Further enhancements tend to make the image busy and difficult to interpret     

Singular value properties of LQ regulators

The closed-loop singular values of an LQ regulator transfer function are proved to be no greater than the singular values of the open-loop transfer function and, in the case of output-weighted cost function, to be no greater than the output-weighting parameter     

Spatial soliton-induced guiding by cross-phase modulation

The authors show that spatial solitons are able to induce the stable guiding of a weak probe beam in a homogeneous Kerr-type nonlinear media through cross-phase modulation (XPM). The modes of the induced waveguide are derived from the propagation equation of the probe. Experiments have been performed in Kerr liquid CS₂, with beams of picosecond duration at infrared and visible wavelengths. Stable guiding of a green probe induced by an IR soliton beam has been demonstrated in several different experimental situations. Induced antiguiding and beam splitting are also reported for pump and probe of perpendicular polarizations. All results are in excellent agreement with numerical simulations of the propagation     

Speed reduction on through roads in Nordrhein-Westfalen.

The paper describes a program of experiments for speed reduction on 28 through roads in Nordrhein-Westfalen. In the process, different measures of construction, design, and traffic control were examined to determine their usefulness to reduce speed and to improve road safety. The need for systematic evaluation of a catalogue of measures partly resulted in unsatisfactory design conceptions for the through roads. The evaluation of the effects of the program has been carried out by use of before-and-after-studies of large extent. The speed measurements show that a distinct speed reduction can be obtained only from selected physical improvements. Measures based on optical effects and traffic signs were found to have very little effect on vehicle speeds. Furthermore, in light of the relatively small number of accidents that occur on the selected facilities, it was not possible to establish the beneficial impact of each specific control measure with statistical certainty. However, the results of the experiment have had an influence on the current definition of new design standards for main urban streets in Germany.