The effects of shadow‐fading on QoS‐aware routing and admission control protocols designed for multi‐hop MANETs

Providing quality‐of‐service (QoS) assurances in a mobile ad hoc network (MANET) is difficult due to node mobility, contention for channel access, a lack of centralised coordination, and the unreliable nature of the wireless channel. QoS‐aware routing (QAR) and admission control (AC) protocols comprise two of the most important components of a system attempting to provide QoS guarantees in the face of the above‐mentioned difficulties. This paper presents a comparative study, utilising a realistic shadow fading channel, of the performance of several state‐of‐the‐art amalgamated QAR‐AC protocols, which are designed for providing throughput guarantees to applications. The advantages and drawbacks of their particular features are highlighted. For an environment where link quality varies rapidly, the results of the study highlight the ineffectiveness of previously‐proposed methods of relying merely on the success of route discovery to perform AC, of relying on the exceeding of the MAC layer retransmission count for link failure detection, of existing congestion detection schemes and of careful re‐admission of data sessions rather than fast re‐routing after shadowing‐induced link failures. Based on the lessons learnt, design guidelines for future QAR and AC protocols operating in a mobile shadow‐fading‐afflicted environment are presented. Copyright © 2010 John Wiley & Sons, Ltd.     

Ligand-specific conformations of an ionotropic glutamate receptor

A simple in silico procedure is proposed with a view to predictthe agonist or antagonist character of new, AMPA-type Glu receptorchannel ligands. Based on the experimental binding domain structures,the orientation of a single Lys residue close to the ligandbinding core was found to be diagnostic of ligand-induced conformationalchanges. Acting as a switch, the position of the Lys residueindicates the agonist or antagonist character of AMPA receptorligands, known to bind to the receptor. Stability centre analysissubstantiated the key role this switch might play in ligand-inducedconformational changes.     

奥钢联(VAI)紧凑型连铸机--增加板坯生产能力及灵活生产的新型连铸机理念

介绍了采用一流导向系统、双机铸造板坯宽度达2×1600 mm,单机铸造板坯最大宽度为3500mm新型板坯连铸机技术的可能性.在双机铸造的模式下,可以分别控制每块板坯,而结晶器振动系统和铸造速度也是独立控制的.在单机铸造的模式下,两流生产线是同步作业的.     

Algorithmic properties of maximal orders in simple algebras over Q

This paper addresses an algorithmic problem related to associative algebras. We show that the problem of deciding if the index of a given central simple algebra over an algebraic number field isd, whered is a given natural number, belongs to the complexity classN P co N P. As consequences, we obtain that the problem of deciding if is isomorphic to a full matrix algebra over the ground field and the problem of deciding if is a skewfield both belong toN P co N P. These results answer two questions raised in [25]. The algorithms and proofs rely mostly on the theory of maximal orders over number fields, a noncommutative generalization of algebraic number theory. Our results include an extension to the noncommutative case of an algorithm given by Huang for computing the factorization of rational primes in number fields and of a method of Zassenhaus for testing local maximality of orders in number fields.     

Symmetric RBF classifier for nonlinear detection in multiple-antenna-aided systems.

In this paper, we propose a powerful symmetric radial basis function (RBF) classifier for nonlinear detection in the so-called "overloaded" multiple-antenna-aided communication systems. By exploiting the inherent symmetry property of the optimal Bayesian detector, the proposed symmetric RBF classifier is capable of approaching the optimal classification performance using noisy training data. The classifier construction process is robust to the choice of the RBF width and is computationally efficient. The proposed solution is capable of providing a signal-to-noise ratio (SNR) gain in excess of 8 dB against the powerful linear minimum bit error rate (BER) benchmark, when supporting four users with the aid of two receive antennas or seven users with four receive antenna elements.     

Magnetically controlled valve for flow manipulation in polymer microfluidic devices

A simple, external in-line valve for use in microfluidic devices constructed of polydimethylsiloxane (PDMS) is described. The actuation of the valve is based on the principle that flexible polymer walls of a liquid channel can be pressed together by the aid of a permanent magnet and a small metal bar. In the presence of a small NdFeB magnet lying below the channel of interest, the metal bar is pulled downward simultaneously pushing the thin layer of PDMS down thereby closing the channel stopping any flow of fluid. The operation of the valve is dependent on the thickness of the PDMS layer, the height of the channel, the gap between the chip and the magnet and the strength of the magnet. The microfluidic channels are completely closed to fluid flows ranging from 0.1 to 1.0 μL/min commonly used in microfluidic applications.     

Expression and Functional Studies on the Noncoding RNA,PRINS

PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated variable expressions in different human tissues and a consistent staining pattern in epidermal keratinocytes and in vitro cultured keratinocytes. To identify the cellular function(s) of PRINS, we searched for a direct interacting partner(s) of this stress-induced molecule. In HaCaT and NHEK cell lysates, the protein proved to be nucleophosmin (NPM) protein as a potential physical interactor with PRINS. Immunohistochemical experiments revealed an elevated expression of NPM in the dividing cells of the basal layers of psoriatic involved skin samples as compared with healthy and psoriatic uninvolved samples. Others have previously shown that NPM is a ubiquitously expressed nucleolar phosphoprotein which shuttles to the nucleoplasm after UV-B irradiation in fibroblasts and cancer cells. We detected a similar translocation of NPM in UV-B-irradiated cultured keratinocytes. The gene-specific silencing of PRINS resulted in the retention of NPM in the nucleolus of UV-B-irradiated keratinocytes; suggesting that PRINS may play a role in the NPM-mediated cellular stress response in the skin.     

Protease evolution in Streptomyces griseus. Discovery of a novel dimeric enzymes

This report describes the cloning and sequencing of a novel protease gene derived from Streptomyces griseus. Also described is the heterologous expression of the gene in Bacillus subtilis and characterization of the gene product. The sprD gene encodes a prepro mature protease of 392 amino acids tentatively named S. griseus protease D (SGPD). A significant component of the enzyme preregion was found to be homologous with the mitochondrial import signal of hsp60. The sprD gene was subcloned into an Escherichia coli/B. subtilis shuttle vector system such that the pro mature portion of SGPD was fused in frame with the promoter, ribosome binding site, and signal sequences of subtilisin. The gene fusion was subsequently expressed in B. subtilis DB104, and active protease was purified. SGPD has a high degree of sequence homology to previously described S. griseus proteases A, B, C, and E and the alpha-lytic protease of Lysobacter enzymogenes, but unlike all previously characterized members of the chymotrypsin superfamily, the recombinant SGPD forms a stable alpha 2 dimer. The amino acid sequence of the protein in the region of the specificity pocket is similar to that of S. griseus proteases A, B, and C. The purified enzyme was found to have a primary specificity for large aliphatic or aromatic amino acids. Nucleotide sequence data were used to construct a phylogenetic tree using a method of maximum parsimony which reflects the relationships and potentially the lineage of the chymotrypsin-like proteases of S. griseus.