Neutrinos from photo-hadronic interactions in Pks2155-304

The high-peaked BL Lac object Pks2155-304 shows high variability at multiwavelengths, i.e. from optical up to TeV energies. A giant flare of around 1 h at X-ray and TeV energies was observed in 2006 [1]. In this context, it is essential to understand the physical processes in terms of the primary spectrum and the radiation emitted, since high-energy emission can arise in both leptonic and hadronic processes. In this contribution, we investigate the possibility of neutrino production in photo-hadronic interactions. In particular, we predict a direct correlation between optical and TeV energies at sufficiently high optical radiation fields. We show that in the blazar Pks2155-304, the optical emission in the low-state is sufficient to lead to photo-hadronic interactions and therefore to the production of high-energy photons.     

Steric Crowding Makes Challenging C(sp3)-F Reductive Eliminations Feasible

A high-yielding fluorination of (triphos)Pt-R(+) has been achieved using an array of F(+) sources, with XeF(2) yielding R-F in minutes. The C-F coupling proved to be a stereoretentive process that proceeds via a concerted reductive elimination from a putative dicationic Pt(IV) center. The larger the steric congestion of the (triphos)Pt-C(sp3) (+) complexes, the more efficient the fluorination, seemingly a result of sterically accelerated C-F reductive elimination along with simultaneous deceleration of its competing processes (β-H elimination).     

A comparison of two sampling methods for global sensitivity analysis

We compare the convergence properties of two different quasi-random sampling designs – Sobol?s quasi-Monte Carlo, and Latin supercube sampling in variance-based global sensitivity analysis. We use the non-monotonic V-function of Sobol? as base case-study, and compare the performance of both sampling strategies at increasing sample size and dimensionality against analytical values. The results indicate that in almost all cases investigated here, the Sobol? design performs better. This, coupled with the fact that effective Latin supercube sampling requires a priori knowledge of the interaction properties of the function, leads us to recommend Sobol? sampling in most practical cases.     

Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD

Object  The aim of our study was to determine total cystic volume in a mouse model of PKD using MR imaging to monitor therapeutic effects in vivo. Materials and methods  We imaged eight female pcy-mice in two groups: four belonged to an untreated control group and four were treated with the anticystic agent rapamycin, which has proven to be effective in reducing cystogenesis in animal models. The mice were imaged using a 9.4 Tesla animal scanner. MRI measurements were taken at six time points during the therapy. Total renal volumes and total cyst volumes were calculated using a thresholding approach. Results  During the course of the treatment, the total cyst volume increased significantly faster than the total renal volume in the untreated group, indicating that growth of the total renal volume in the untreated group was primarily due to the growth of the cysts, rather than the parenchyma. The measured total renal volume in the control (placebo) group was significantly higher than the volume in the treated group. Conclusion  Using MRI, we were able to monitor the cystic volume in a mouse model of PKD to assess the therapeutic effect of anticystic treatment.     

Mode I–III Decomposition of the J‐integral from DIC Displacement Data

This paper presents the implementation of the decomposition method on digital image correlation (DIC) obtained displacement fields to obtain J‐integral results (J) and respective stress intensity factors (SIFs). DIC is increasingly used with the J‐integral approach in experimental mechanics to obtain J estimates from complex fracture processes. In this approach, the decomposition method is applied to DIC displacement fields for the first time. Here, displacement fields are separated before stresses and strains are computed, so that subsequent computation of separate J or SIF components may follow the classical full‐field J‐integral approach. The sensitivity of the decomposition method to experimental errors is investigated using synthetically generated errors imposed on crack tip displacement fields (Williams' series), from which improvements to the procedure are proposed. The method is experimentally tested on PMMA Arcan specimens under mode I, II, and III, and mixed‐mode I–III loading. Test results were compared to fracture toughness values obtained from ASTM tests and literature with close agreement.     

Isolation and characterization of natural Ara h 6: evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat

Peanut allergy is a significant health problem because of its prevalence and the potential severity of the allergic reaction. The characterization of peanut allergens is crucial to the understanding of the mechanism of peanut allergy. Recently, we described cloning of the peanut allergen Ara h 6. The aim of this study was isolation and further characterization of nAra h 6. We purified nAra h 6 from crude peanut extract using gel filtration and anion exchange chromatography. The preparation was further characterized by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) with subsequent immunoblotting. Stability of nAra h 6 was studied by an in vitro digestibility assay as well as by resistance against thermal processing. Sequencing of nAra h 6 identified the N-terminal amino acid sequence as MRRERGRQGDSSS. Further results clearly demonstrated stability of nAra h 6 against pepsin digestion and heating. Immunoglobulin G (IgE) binding analysis and its biological activity shown by RBL 25/30-test of natural Ara h 6 supported the importance of this peanut allergen. Investigation of nAra h 6 revealed evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat.