Does sodium fluoride in bone cement affect implant fixation? Part I: Bone tissue response, implant fixation and histology in nine rabbits

The addition of sodium fluoride to poly (methyl-methacrylate) (PMMA) bone cement may theoretically improve the fixation of joint replacement. This hypothesis was tested in an animal model using nine mature healthy lop-eared rabbits. A femoral prosthesis was inserted in both knees to resurface the patellofemoral articulation. The same acrylic cement, with and without sodium fluoride, was randomised between the two sides for prosthetic fixation. Two screw shaped implants machined from cured rods of either cement were also inserted bilaterally into the proximal tibia. Qualitative and quantitative histomorphometry of the bone tissue response surrounding the cement in the femur and the intact tibial implants revealed similar results regardless of sodium fluoride addition. Six weeks after surgery removal, torque did not significantly differ between the two sides. Our findings indicate that addition of sodium fluoride to PMMA has little effect on implant stability and bone remodeling in rabbits in the short-term.     

Lipids and endothelium-dependent vasodilation—A review

Studies using both in vitro and in vivo techniques have repeatedly shown that endothelium-dependent vasodilation (EDV) is impaired in different forms of experimental as well as human hypercholesterolemia. Clearly this impaired EDV can be reversed by lowering cholesterol levels by diet or medical therapy. Competitive blocking of l-arginine, changes in nitric oxide synthase acitivity, increased release of endothelin-1, and inactivation of nitric oxide due to superoxide ions all contribute to the impairment in EDV during dyslipidemia. The oxidation of low density lipoprotein, with its compound lysophosphatidylcholine, plays a critical role in these events. However, data on the role of triglycerides and fat-rich meals regarding EDV are not so consistent as data for cholesterol, although a view that the compositions of individual fatty acids and antioxidants are of major importance is emerging. Thus, this review shows that while impaired FDV is a general feature of hypercholesterolemia, the mechanisms involved and the therapeutic opportunities available still have to be investigated. Furthermore, discrepancies regarding the role of triglycerides and fat content in food may be explained by divergent effects of different fatty acids on the endothelium.     

Physical workload on neck and upper limb using two CAD applications

The aim was to evaluate (1) the physical workload on neck and upper limb in computer-aided design (CAD) work; (2) the impact of two applications (PROFESSIONAL-CADAM and PRO/Engineering) and (3) two input devices (computer mouse and keyboard), as well as (4) sitting and standing work positions. Fifteen CAD operators were interviewed and examined physically. For nine subjects, the physical workload was measured: electromyography (EMG) of trapezius and forearm extensor muscles, inclinometry of the head, the upper back and upper arms, as well as wrist goniometry. The muscular load was low in CAD work, but the inter-individual variation was considerable. Neither the positions were extreme, nor the movements. The applications, per se, did not have a large impact on the workload, but because of the need for different input devices the effect was strong. Using a keyboard meant higher angular velocities than using a mouse. Hence, when choosing a new software, which requires mainly a mouse as input device, this has to be balanced against the risk of disorders.     

Surveyance of disease frequency in a population by linkage to diagnostic laboratory databases. A system for monitoring the incidences of hyper- and hypothyroidism as part of the Danish iodine supplementation program

In Denmark an increase in iodine intake through salt iodization has been introduced in 1998. In parallel a program for surveyance of thyroid diseases in the population was developed as recommended by UNICEF and WHO. OBJECTIVE: To develop and evaluate a computer based system to identify and register new cases of hyper- and hypothyroidism in a well defined cohort, by linkage to diagnostic laboratory databases. DESIGN AND RESULTS: (1) Two sub cohorts for monitoring were defined (n=535,859), and evaluated to minimize loss of new cases. Collaboration was established with laboratories covering thyroid hormone analyses in the cohort; (2) a diagnostic algorithm was defined and evaluated against clinical practice; (3) evaluation of the laboratory methods employed by the four participating laboratories, to ensure they would reach the same diagnosis in a patient; (4) a register database was developed which used data imported from the laboratory databases to automatically identify previously unknown cases of hyper- and hypothyroidism and record diagnostic activity in the area. All parts of the registration were carefully evaluated. CONCLUSION: We describe for the first time a computer based system for prospective measuring the incidence rate of hyper- and hypothyroidism. The system is particularly useful for monitoring of iodine supplementation programmes.     

Impact of understory vegetation on forest canopy reflectance and remotely sensed LAI estimates

Forest leaf area index (LAI), is an important variable in carbon balance models. However, understory vegetation is a recognized problem that limits the accuracy of satellite-estimated forest LAI. A canopy reflectance model was used to investigate the impact of the understory vegetation on LAI estimated from reflectance values estimated from satellite sensor data. Reflectance spectra were produced by the model using detailed field data as input, i.e. forest LAI, tree structural parameters, and the composition, distribution and reflectance of the forest floor. Common deciduous and coniferous forest types in southern Sweden were investigated. A negative linear relationship (r² = 0.6) was observed between field estimated LAI and the degree of understory vegetation, and the results indicated better agreement when coniferous and deciduous stands were analysed separately. The simulated spectra verified that the impact of the understory on the reflected signal from the top of the canopy is important; the reflectance values varying by up to ± 18% in the red and up to ± 10% in the near infra-red region of the spectra due to the understory. In order to predict the variation in LAI due to the understory vegetation, model inversions were performed where the input spectra were changed between the minimum, average and maximum reflectance values obtained from the forward runs. The resulting variation in LAI was found to be 1.6 units on average. The LAI of the understory could be predicted indirectly from simple stand data on forest characteristics, i.e. from allometric estimates, as an initial step in the process of estimating LAI. It is suggested here that compensation for the effect of the understory would improve the accuracy in the estimates of canopy LAI considerably.     

Optimal recovery schemes in fault tolerant distributed computing

Clusters and distributed systems offer fault tolerance and high performance through load sharing. When all n computers are up and running, we would like the load to be evenly distributed among the computers. When one or more computers break down, the load on these computers must be redistributed to other computers in the system. The redistribution is determined by the recovery scheme. The recovery scheme is governed by a sequence of integers modulo n. Each sequence guarantees minimal load on the computer that has maximal load even when the most unfavorable combinations of computers go down. We calculate the best possible such recovery schemes for any number of crashed computers by an exhaustive search, where brute force testing is avoided by a mathematical reformulation of the problem and a branch-and-bound algorithm. The search nevertheless has a high complexity. Optimal sequences, and thus a corresponding optimal bound, are presented for a maximum of twenty one computers in the distributed system or cluster.Received: 26 May 2004, Published online: 14 March 2005     

Can you Trust a Single Data Source Exploratory Software Engineering Case Study?

As the demand for empirical evidence for claims of improvements in software development and evolution has increased, the use of empirical methods such as case studies has grown. In case study methodology various types of triangulation is a commonly recommended technique for increasing validity. This study investigates a multiple data source case study with the objective of identifying whether more findings, trustworthier findings and other findings are made using multiple data source triangulation, than had a single data source been used. The case study investigated analyses key lead-time success factors for a software evolution project in a large organization developing eBusiness systems with high-availability high throughput transaction characteristics. By tracing each finding in that study to the individual evidences motivating the finding, it is suggested that a multiple data source explorative case study can have a higher validity than a single data source study. It is concluded that a careful case study design with multiple sources of evidence can result in not only better justified findings than a single data source study, but also other findings. Thus this study provides empirically derived evidence that a multiple data source case study is more trustworthy than a comparable single data source case study.     

A proxy architecture for collaborative media streaming

Streaming media from the Internet is a successful application for end-users. With the upcoming success of mobile devices and home networking environments, cooperation among users will become more important in the future. To achieve such cooperation, explicit middleware standards have been defined. On the other hand, Internet conferencing applications do not handle collaborative streaming sessions with individual control for each user. We propose a new concept for cooperation exemplary for collaborative media streaming using IETF multimedia session control protocols together with a proxy architecture. This concept enables both synchronization among clients and flexible control to individual users.     

Optical Properties of Doped Antiferromagnets

We investigate the consequences of an incommensurate magnetic order in doped La_2–x Sr _x CuO₄ using dynamical mean-field theory for the effective single-band model. The high-energy optical transitions are due to high-energy excitations across large Mott–Hubbard gap, while low-energy excitations involve a pseudogap induced by the local spin order. The latter lead to a strong drop in the scattering rate at low , in qualitative agreement with the experimental data.