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991.
Ana Laura CIMADOR Emeli Luciana GALANTE Lucila Ibel MUÑOZ Patricia Silvia ROMANO Antonella Denisse LOSINNO María Cristina VANRELL 《Biocell》2019,43(1):13-20
Trypanosoma rangeli and T. cruzi are both parasitic unicellular species that infect humans. Unlike T. cruzi,the causative agent of Chagas disease, T. rangeli is an infective and non-pathogenic parasite for humans, but pathogenicfor vectors from the Rhodnius genus. Because both species can coexist in different hosts and overlap their infectivecycles but very little is known about the infection of T. rangeli in mammalian cells, we decided to characterize both thedevelopment of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action onit. We found that T. rangeli exhibits a cycle of infection in Vero cells similar to that for T. cruzi and that the repurposeddrug, 17-AAG, and the natural extract Artemisia sp. essential oil produce a toxic effect on epimastigotes showinga trypanocidal action from the fifth day of culture. Both treatments also affected the infection of trypomastigotesand reduced the capacity of replication of amastigotes of T. rangeli. Since T. cruzi / T. rangeli coinfection cases havebeen reported, the finding of drugs with potential activity against both species could be significant in the future.Furthermore, studies of susceptibility of both species to drugs could also help to know the different mechanisms ofpathogenicity in humans displayed by T. cruzi that are absent in T. rangeli 相似文献
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Romy Müller Laura Ullrich Ann‐Kathrin Dessel Amelie Bengsch Sebastian Heinze Tobias Müller Lukas Oehm 《人机工程学与制造业中的人性因素》2019,29(1):44-62
In the processing industry, frequent faults call for assistance in diagnosis, and case‐based reasoning (CBR) can provide solutions applied by other operators in the past. This study investigated whether salient case ratings promote an uncritical acceptance of solutions. In 2 experiments, subjects diagnosed faults with a simulated CBR system, and ratings were presented in graphical or verbal format. In most trials, the case with the highest rating provided the correct solution, while in catch‐trials, it did not. Graphical ratings were hypothesized to speed up solutions but discourage cross‐checking and lead to errors in catch‐trials. These hypotheses were not confirmed, even though Experiment 2 maximized the incentive of relying on case ratings. While graphical ratings led subjects to start with the most highly rated case, they did not impair situation analysis and accuracy. The results suggest that during fault diagnosis people are not easily misled into overtrusting a CBR system. 相似文献
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Ilaria Venanzi Oren Lavan Laura Ierimonti Stefano Fabrizi 《Structure and Infrastructure Engineering》2018,14(10):1295-1311
This paper presents a framework for life-cycle loss estimation for non-structural damage in tall buildings under wind and seismic loads. Life-cycle cost analysis is a useful design tool for decision- makers, aimed at predicting monetary losses over the lifetime of a structure, accounting for uncertainties involved in the problem definition. For tall buildings, sensitive to dynamic excitations like earthquake and wind, it can be particularly suitable to base design decisions not only on initial cost and performance but also on future repair expenses. The proposed approach harmonises the procedures for intervention costs evaluation of structures subjected to multiple-hazards, taking into account the peculiar differences of wind and earthquake, in terms of load characterisation, type and evolution of damage. Relative effect of the two hazards on damage to drift- and acceleration-sensitive non-structural elements are examined. The influence of uncertainty in structural damping is also taken into account. It is shown that, although it is commonly believed that the design of a given structure is usually dominated by either winds or earthquakes, when LCC-based design is performed, both winds and earthquakes may be important. 相似文献
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An analytical model for the streamwise velocity space‐time correlations in turbulent flows is derived and applied to the special case of velocity fluctuations in large wind farms. The model is based on the Kraichnan‐Tennekes random sweeping hypothesis, capturing the decorrelation in time while including a mean wind velocity in the streamwise direction. In the resulting model, the streamwise velocity space‐time correlation is expressed as a convolution of the pure space correlation with an analytical temporal decorrelation kernel. Hence, the spatiotemporal structure of velocity fluctuations in wind farms can be derived from the spatial correlations only. We then explore the applicability of the model to predict spatiotemporal correlations in turbulent flows in wind farms. Comparisons of the model with data from a large eddy simulation of flow in a large, spatially periodic wind farm are performed, where needed model parameters such as spatial and temporal integral scales and spatial correlations are determined from the large eddy simulation. Good agreement is obtained between the model and large eddy simulation data showing that spatial data may be used to model the full spatiotemporal structure of fluctuations in wind farms. 相似文献
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