Insights into the In Vitro Formation of Apatite from Mg-Stabilized Amorphous Calcium Carbonate

A protein-free formation of bone-like apatite from amorphous precursors through ball-milling is reported. Mg²⁺ ions are crucial to achieve full amorphization of CaCO₃. Mg²⁺ incorporation generates defects which strongly retard a recrystallization of ball-milled Mg-doped amorphous calcium carbonate (BM-aMCC), which promotes the growth of osteoblastic and endothelial cells in simulated body fluid and has no effect on endothelial cell gene expression. Ex situ snapshots of the processes revealed the reaction mechanisms. For low Mg contents (<30%) a two phase system consisting of Mg-doped amorphous calcium carbonate (ACC) and calcite “impurities” was formed. For high (>40%) Mg²⁺ contents, BM-aMCC follows a different crystallization path via magnesian calcite and monohydrocalcite to aragonite. While pure ACC crystallizes rapidly to calcite in aqueous media, Mg-doped ACC forms in the presence of phosphate ions bone-like hydroxycarbonate apatite (dahllite), a carbonate apatite with carbonate substitution in both type A (OH⁻) and type B (PO₄³⁻) sites, which grows on calcite “impurities” via heterogeneous nucleation. This process produces an endotoxin-free material and makes BM-aMCC an excellent “ion storage buffer” that promotes cell growth by stimulating cell viability and metabolism with promising applications in the treatment of bone defects and bone degenerative diseases.     

DFM“共用平台”技术的进展

新加坡特许半导体制造有限公司的J．B．Tan不久将推出五大成品率及可靠性问题的解决方案，结合多层互连结构及铜和低k介质集成。工程师们在互连工艺向批量生产过渡之前对这些问题进行了验证，并在6月5-7日在加州Burlingame举行的“国际互连技术会议”中推出研究成果。     

成品率的预测准确度有多高

成品率预测是可制造性设计（DFM）的基础之，但它还远不止于此。IBM系统和技术群300mm半导体运营副总裁DanArmbrust说：“我们精确预测成品率的能力就是我们的经济模式。”Armbrust是SEMICON West 2007成品率论坛讨论DFM现状的三位参与者之一。与他共同参加讨论的是Synopsys公司DFM解决方案副总裁Anantha Sethuraman和Photronics公司的CTO Chris Progler。     

Dynamic multicast link selections for buffer‐aided relaying networks

The management of small cell is considered a key point in next‐generation cellular networks for providing higher data rates, and the relay nodes are expected to be useful to improve the coverage area. Moreover, multicast services have gained importance to disseminate common data to subscribers. The use of buffer‐aided relay for multicast communications is analysed in the paper, and different policies to perform the optimal link selections are compared. These policies are based on the knowledge of the instantaneous link quality indicators as well as the status of the relay buffer and dynamically select the better link according to a suitable probabilistic criterion by improving the aggregate multicast flows. The parameters of these multicast policies are optimized via a Markov chain theoretical framework. The performance for all the proposed methods is analytically derived and validated through computer simulations conducted in different multicast scenarios. The advantages of the proposed schemes are pointed out in terms of multicast throughput, buffer occupancy for different buffer and multicast group size. Copyright © 2016 John Wiley & Sons, Ltd.     

Discovering Homophily in Online Social Networks

Mobile Networks and Applications - During the last ten years, Online Social Networks (OSNs) have increased their popularity by becoming part of the real life of users. Despite their tremendous...     

Optimizing Proportionally Fair Prices

We demonstrate the non-uniqueness of proportional fairness prices, and show that the model of Kelly et al. [9] falls into the category of models that can be generalized to allow optimization of the link prices, with a view toward profit maximization. However, through this framework, we also show that the total revenue that can be obtained through proportional fairness pricing on a network is unique.     

Hybrid Organic/Inorganic Nanostructures for Highly Sensitive Photoelectrochemical Detection of Dissolved Oxygen in Aqueous Media

Precise, reliable, and remote measurement of dissolved oxygen in aqueous media is of great importance for many industrial, environmental, and biological applications. In particular, photoelectrochemical sensors working in differential mode have recently demonstrated promising properties, in terms of stability, sensitivity, and application potential. Here, a new approach is presented, combining visible light sensitivity, efficient photocurrent generation, and solution‐processed fabrication methods of conjugated polymers, with charge carriers selectivity, energetic alignment favorable to efficient interfacial charge transfer and high surface area achievable by using metal oxide nanostructures. Extensive characterization and optimization of the hybrid organic/inorganic system are carried out, leading to the realization of an oxygen sensor device, based on nanostructured palladium oxide/poly[(9,9‐dioctylfluorenyl‐2,7‐diyl)‐alt‐5,5‐(4′,7′‐di‐2‐thienyl‐2′,1′,3′‐benzothiadiazole]/[6,6]phenyl‐C61‐butyric acid methyl ester (PdO/APFO‐3:PCBM) as materials of choice. State‐of‐the‐art sensitivity, amounting at ?5.87 μA cm^?2 ppm^?1, low background signal, in the order of ?4.85 μA cm^?2, good electrochemical stability for more than 2 h of continuous functioning and high reproducibility of the signal over the pH 1 to 10 range, are reported, making the hybrid device suitable for several practical uses. The results fully validate the mixed organic/inorganic approach for photoelectrochemical applications, and pave the way for its further exploitation in fields like waste water treatment, environmental monitoring, and water splitting.     

Precisely Controlled Microsphere Design via Visible‐Light Cross‐Linking of Functional Prepolymers

A new strategy for particle synthesis is enabled by utilizing modern synthetic, polymer, and photochemical techniques to facilitate the synthesis of highly narrow–disperse multifunctional microspheres from visible‐light induced crosslinking of prepolymers in both a single and dual polymer system. The approach requires no stabilizers, bases, or initiators, and proceeds at ambient temperature to yield microspheres with a tunable size range (0.25–5 µm) in less than 4 h, depending largely on solvent composition, but also polymer concentration (2–10 mg mL^?1), ratio, and irradiation intensity (3–20 W). Critically, the visible‐light induced dimerization reaction exploited herein enables simple functional particle syntheses via a single polymer system. Underpinned by an in‐depth kinetic analysis of the particle formation as well as a detailed small molecule study, the mechanism for particle formation is also elucidated. Importantly, inherent advantages of the system are exploited for surface functionalization of residual acrylate and hydroxyl groups (generating inherently fluorescent particles).     

Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging

Multimodality medical imaging takes advantage of the strengths of different imaging modalities to provide a more complete picture of the anatomy under investigation. Many complementary modalities have been combined to form such systems and some are gaining use clinically. One combination that has not been developed, in large part due to technical difficulties, is a combined magnetic resonance (MR) and ultrasound (US) imaging system. Such a system offers the potential to combine the strengths of these modalities in a wide range of diagnostic and therapeutic applications. The goal of this study was to evaluate the feasibility of performing simultaneous multimodality US and MR imaging. An US imaging system capable of operation in a clinical MR imager was developed, and methods to perform simultaneous imaging were investigated. Simultaneous imaging was feasible without any mutual interference by either filtering the transmitted and received US signal, or by synchronizing data acquisition between the two imaging systems. Spatial registration between the two modalities was achieved by using a reference phantom with implanted glass beads in orthogonal planes. Excellent agreement was observed between spatial measurements of an object made with both modalities, and the feasibility of using this system in vivo was demonstrated in a rabbit model. Simultaneous US and MR imaging is achievable, and can provide complementary information about an object under investigation. This demonstration of technical feasibility and the development of a prototype system open up the potential to investigate the promising clinical applications of this combined technology.     

缺陷问题驱动浸没光刻技术发展

涂层的应用导致晶圆上缺陷的增加或者使光刻表现发生变化虽然现在推测浸没光刻技术的量产时间还太早,但是许多公司正在努力确定生产线何时能从干法工艺跃为湿法工艺。根据最近在San Jose举办的