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11.
Malta Loretta S. Giosan Cezar Szkodny Lauren E. Altemus Margaret M. Rizzo Albert A. Silbersweig David A. Difede JoAnn 《Virtual Reality》2021,25(2):293-302
Virtual Reality - This research report describes the development of a virtual reality (VR) laboratory stressor to study the effects of exposure to stressful events. The aim of the research was to... 相似文献
12.
The ability to trap precise quantities of cells or particles into confined areas has numerous applications for biological purposes. In particular, single cell trapping has received considerable attention because it permits the study of heterogeneity in a population, while trapping larger groups of cells have been used to form aggregates. Among several methods, the use of microwell offers a simple platform to capture cells or particles using hydrodynamic forces. This review examines the use of microwells in both static and microfluidic environments, and the application of microfluidic geometric arrays for trapping. This paper discusses the design and fabrication methods of microwells and compares the trapping and release techniques used in both static and microfluidics‐integrated microwells. Finally, we will summarize novel microfluidic geometric arrays used to capture cells or particles through hydrodynamic trapping. 相似文献
13.
Diversity in Addressing Reaction Mechanisms of Nano‐Thermite Composites with a Layer by Layer Structure
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14.
Nikolaus Correll Nikos Arechiga Adrienne Bolger Mario Bollini Ben Charrow Adam Clayton Felipe Dominguez Kenneth Donahue Samuel Dyar Luke Johnson Huan Liu Alexander Patrikalakis Timothy Robertson Jeremy Smith Daniel Soltero Melissa Tanner Lauren White Daniela Rus 《Intelligent Service Robotics》2010,3(4):219-232
This paper describes the architecture and implementation of a distributed autonomous gardening system with applications in urban/indoor precision agriculture. The garden is a mesh network of robots and plants. The gardening robots are mobile manipulators with an eye-in-hand camera. They are capable of locating plants in the garden, watering them, and locating and grasping fruit. The plants are potted cherry tomatoes enhanced with sensors and computation to monitor their well-being (e.g. soil humidity, state of fruits) and with networking to communicate servicing requests to the robots. By embedding sensing, computation, and communication into the pots, task allocation in the system is de-centrally coordinated, which makes the system scalable and robust against the failure of a centralized agent. We describe the architecture of this system and present experimental results for navigation, object recognition, and manipulation as well as challenges that lie ahead toward autonomous precision agriculture with multi-robot teams. 相似文献
15.
Haeffel Gerald J.; Abramson Lyn Y.; Voelz Zachary R.; Metalsky Gerald I.; Halberstadt Lisa; Dykman Benjamin M.; Donovan Patricia; Hogan Michael E.; Hankin Benjamin L.; Alloy Lauren B. 《Canadian Metallurgical Quarterly》2005,5(3):343
Results from studies using a behavioral high-risk design and approximations to it generally have corroborated the cognitive vulnerability hypothesis of depression, whereas results from remitted depression studies typically have not. Suspecting that design features of previously conducted remitted designs likely precluded them from detecting maladaptive cognitive patterns, the authors conducted a study featuring the remitted design that has been successful in studies of a biological vulnerability for depression. Participants' current depressive symptoms, negative cognitive styles (hopelessness theory), dysfunctional attitudes (Beck's theory), and lifetime prevalence of clinically significant depression were assessed. Participants who had remitted from an episode of clinically significant depression had more negative cognitive styles, but not greater levels of dysfunctional attitudes, than did never depressed individuals. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
16.
Jennifer Therkorn David Drewry III Thomas Pilholski Kathryn Shaw‐Saliba Gregory Bova Lisa L. Maragakis Brian Garibaldi Lauren Sauer 《Indoor air》2019,29(1):143-155
Biocontainment units (BCUs) are facilities used to care for patients with highly infectious diseases. However, there is limited guidance on BCU protocols and design. This study presents the first investigation of how HVAC (heating, ventilation, air‐conditioning) operating conditions influence the dissemination of fluorescent tracer particles released in a BCU. Test conditions included normal HVAC operation and exhaust failure resulting in loss of negative pressure. A suspension of optical brightener powder and water was nebulized to produce fluorescent particles simulating droplet nuclei (0.5‐5 μm). Airborne particle number concentrations were monitored by Instantaneous Biological Analyzers and Collectors (FLIR Systems). During normal HVAC operation, fluorescent tracer particles were contained in the isolation room (average concentration = 1 × 104 ± 3 × 103/Lair). Under exhaust failure, the automated HVAC system maximizes airflow into areas adjacent to isolation rooms to attempt to maintain negative pressure differential. However, 6% of the fluorescent particles were transported through cracks around doors/door handles out of the isolation room via airflow alone and not by movement of personnel or doors. Overall, this study provides a systematic method for evaluating capabilities to contain aerosolized particles during various HVAC scenarios. Recommendations are provided to improve situation‐specific BCU safety. 相似文献
17.
Alyssa N. Preston Joshua D. Farr Kevin C. Tan Danielle A. Cervasio Lauren R. Butkus Prof. Dr. Scott T. Laughlin 《Chembiochem : a European journal of chemical biology》2019,20(3):366-370
The brain's astrocytes play key roles in normal and pathological brain processes. Targeting small molecules to astrocytes in the presence of the many other cell types in the brain will provide useful tools for their visualization and manipulation. Herein, we explore the functional consequences of synthetic modifications to a recently described astrocyte marker composed of a bright rhodamine-based fluorophore and an astrocyte-targeting moiety. We altered the nature of the targeting moiety to probe the dependence of astrocyte targeting on hydrophobicity, charge, and pKa when exposed to astrocytes and neurons isolated from the mouse cortex. We found that an overall molecular charge of +2 and a targeting moiety with a heterocyclic aromatic amine are important requirements for specific and robust astrocyte labeling. These results provide a basis for engineering astrocyte-targeted molecular tools with unique properties, including metabolite sensing or optogenetic control. 相似文献
18.
19.
Thomas R. Bieler Bite Zhou Lauren Blair Amir Zamiri Payam Darbandi Farhang Pourboghrat Tae-Kyu Lee Kuo-Chuan Liu 《Journal of Electronic Materials》2012,41(2):283-301
Because failures in lead-free solder joints occur at locations other than the most highly shear-strained regions, reliability
prediction is challenging. To gain physical understanding of this phenomenon, physically based understanding of how elastic
and plastic deformation anisotropy affect microstructural evolution during thermomechanical cycling is necessary. Upon solidification,
SAC305 (Sn-3.0Ag-0.5Cu) solder joints are usually single or tricrystals. The evolution of microstructures and properties is
characterized statistically using optical and orientation imaging microscopy. In situ synchrotron x-ray measurements during thermal cycling are used to examine how crystal orientation and thermal cycling history
change strain history. Extensive characterization of a low-stress plastic ball grid array (PBGA) package design at different
stages of cycling history is compared with preliminary experiments using higher-stress package designs. With time and thermal
history, microstructural evolution occurs mostly from continuous recrystallization and particle coarsening that is unique
to each joint, because of the specific interaction between local thermal and displacement boundary conditions and the strong
anisotropic elastic, plastic, expansion, and diffusional properties of Sn crystals. The rate of development of recrystallized
microstructures is a strong function of strain and aging. Cracks form at recrystallized (random) boundaries, and then percolate
through recrystallized regions. Complications arising from electromigration and corrosion are also considered. 相似文献
20.
Howard J. Walls Jean H. Kim Robert W. Yaga Lauren A. Harvey Laura G. Haines David S. Ensor 《Aerosol science and technology》2017,51(5):576-586
Sampling for culturable (e.g., viable) aerosolized microbes (bioaerosols) is a useful means to provide information for public health monitoring and studies. However, it is challenging to maintain microbe culturability when sampling at high flow rates (>12 L/min) and extended periods of time (≥4 h). We developed a first-generation, viable bioaerosol collection system (VBCS) utilizing temperature (T) and relative humidity (RH)–conditioned filtration at a flow rate of 25 L/min. A two-stage system of tube-in-shell Nafion? exchange units provides cooling to ≤10°C and RH conditioning to 80–95%. Aerosol particles are collected on a polyurethane nanofiber filter providing a physical collection efficiency of >95% for sizes 0.06–10 µm. The T and RH conditions at the collection filter are maintained, despite changes to ambient conditions. The initial testing of the VBCS was done under indoor, laboratory conditions with aerosolized, vegetative E. coli. A scenario of a 30-min challenge of bioaerosol followed by continued sampling of clean air for various times was used to judge culturability maintenance under extended-term sampling. An initial loss of culturability upon collection onto the filter was observed; 23 ± 13% relative to 4-mm all-glass impinger. However once collected, 98% of culturability was maintained for an additional 4.5 h of sampling. An exponential decay in culturability was observed from 8 h to 15 h of sampling. Also, 24-h cold storage of the filters collected was studied. The VBCS is based on the use of dry filter cassettes, needs minimal maintenance, and preserves culturability of vegetative bacteria for >4 h.© 2017 RTI International and Aerosol Dynamics Inc. 相似文献