A transparent hybrid of nanocrystalline cellulose and amorphous calcium carbonate nanoparticles

Nanocellulose hybrids are promising candidates for biodegradable multifunctional materials. Hybrids of nanocrystalline cellulose (NCC) and amorphous calcium carbonate (ACC) nanoparticles were obtained through a facile chemical approach over a wide range of compositions. Controlling the interactions between NCC and ACC results in hard, transparent structures with tunable composition, homogeneity and anisotropy.     

Rational design, synthesis and pharmacological evaluation of the (2R)- and (2S)-stereoisomers of 3-(2-carboxypyrrolidinyl)-2-methyl acetic acid as ligands for the ionotropic glutamate receptors

In this paper we describe the rational design, synthesis and pharmacological evaluation of two new stereoisomeric (S)‐glutamate (Glu) analogues. The rational design was based on hybrid structures of the natural product kainic acid, a synthetic analogue CPAA and the high‐affinity Glu analogue SYM2081. Pharmacological evaluation of the two stereoisomers revealed that one stereoisomer showed a subtype selectivity profile with low micromolar affinity for GluK1 and GluK3 and a 10‐ to 15‐fold lower affinity for GluK2. The other stereoisomer displayed full selectivity for the KA over AMPA and NMDA receptors (GluK1–3: 0.39, 0.51 and 0.099 µM , respectively).     

Telescoping Languages: A Strategy for Automatic Generation of Scientific Problem-Solving Systems from Annotated Libraries

As machines and programs have become more complex, the process of programming applications that can exploit the power of high-performance systems has become more difficult and correspondingly more labor-intensive. This has substantially widened the software gap—the discrepancy between the need for new software and the aggregate capacity of the workforce to produce it. This problem has been compounded by the slow growth of programming productivity, especially for high-performance programs, over the past two decades. One way to bridge this gap is to make it possible for end users to develop programs in high-level domain-specific programming systems. In the past, a major impediment to the acceptance of such systems has been the poor performance of the resulting applications. To address this problem, we are developing a new compiler-based infrastructure, called TeleGen, that will make it practical to construct efficient domain-specific high-level languages from annotated component libraries. We call these languages telescoping languages, because they can be nested within one another. For programs written in telescoping languages, high performance and reasonable compilation times can be achieved by exhaustively analyzing the component libraries in advance to produce a language processor that recognizes and optimizes library operations as primitives in the language. The key to making this strategy practical is to keep compile times low by generating a custom compiler with extensive built-in knowledge of the underlying libraries. The goal is to achieve compile times that are linearly proportional to the size of the program presented by the user, rather than to the aggregate size of that program plus the base libraries.     

Heterocycles as Nonclassical Bioisosteres of α‐Amino Acids

Bioisosterism of α‐amino acids is often accomplished by replacing the α‐carboxylate with one of the many known carboxylic acid bioisosteres. However, bioisosterism of the whole α‐amino acid moiety is accomplished with heterocyclic bioisosteres that often display an acidic function. In this Minireview, we summarized the reported heterocycles as nonclassical bioisosteres of α‐amino acids, which include quinoxaline‐2,4(1H)‐dione, quinoxaline‐2,3(1H)‐dione and quinolin‐2(1H)‐one, azagrevellin and azepine‐derived structures. The binding mode of the crystalized bioisosteres were compared with those of the crystalized α‐amino acids that bind in the same domain, and where no data on the crystal structure were available, the displacement studies of known orthosteric ligands were used. The reported bioisosteres share the following essential structural features for mimicking α‐amino acids: an aromatic ring system joined to a lactam ring system with an acidic feature next to the lactam carbonyl, where this acidic feature together with the lactam carbonyl can mimic the α‐carboxylate, and the lactam nitrogen together with the aromatic ring system can mimic the α‐ammonium. The majority of these heterocycles can be prepared from three common corresponding starting materials: the corresponding anilines, isatins or anthranilic esters. The data collected here show the potential of this class of bioisosteres in the design of glutamate receptor ligands and beyond.     

An analysis of the use of electrical power measurements for process control in large‐scale stirred vessels

The mechanical power that is transferred to a liquid via the shaft of an agitator is obtained from a measurement of the electrical power flowing into the electric motor within an accuracy of less than 5%. The accuracy obtained is limited by the calibration procedure. As the implementation of an electric power measurement is both simple and comparatively inexpensive, the technique is suitable for a continuous monitoring of the power used by agitators in the process industries.     

Drop-in replacement of R22 in heat pumps used for district heating — influence of equipment and property limitations

In Swedish district heating systems several large (25 MW) turbo-compressor driven heat pumps using R22 are installed. The only commercially available alternative is R134a, but its use could decrease the heating capacity by 35%. In this paper a method for finding the best working fluid for a specific heat pump plant is presented, and applied to a district heating plant. First, a screening is made among almost 2000 mixtures, using criteria such as condenser pressure, Mach number and temperature glide. Simulations of the plant are then made to investigate the change in heating capacity and COP when using a mixture instead of R134a. The results show that there are mixtures that can offer a substantially higher heating capacity than R134a, but there is a decrease in COP. The importance of considering the limiting parameters of the heat pump, such as maximum volume flow to each compressor stage and minimum evaporator pressure, is shown.     

Long COVID: Association of Functional Autoantibodies against G-Protein-Coupled Receptors with an Impaired Retinal Microcirculation

Long COVID (LC) describes the clinical phenotype of symptoms after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnostic and therapeutic options are limited, as the pathomechanism of LC is elusive. As the number of acute SARS-CoV-2 infections was and is large, LC will be a challenge for the healthcare system. Previous studies revealed an impaired blood flow, the formation of microclots, and autoimmune mechanisms as potential factors in this complex interplay. Since functionally active autoantibodies against G-protein-coupled receptors (GPCR-AAbs) were observed in patients after SARS-CoV-2 infection, this study aimed to correlate the appearance of GPCR-AAbs with capillary microcirculation. The seropositivity of GPCR-AAbs was measured by an established cardiomyocyte bioassay in 42 patients with LC and 6 controls. Retinal microcirculation was measured by OCT–angiography and quantified as macula and peripapillary vessel density (VD) by the Erlangen-Angio Tool. A statistical analysis yielded impaired VD in patients with LC compared to the controls, which was accentuated in female persons. A significant decrease in macula and peripapillary VD for AAbs targeting adrenergic β2-receptor, MAS-receptor angiotensin-II-type-1 receptor, and adrenergic α1-receptor were observed. The present study might suggest that a seropositivity of GPCR-AAbs can be linked to an impaired retinal capillary microcirculation, potentially mirroring the systemic microcirculation with consecutive clinical symptoms.     

Ergonomic procurement guidelines for visual display units as a tool for progressive change

The Swedish Telecommunications Administration (STA) has put to gether a set of requirement specifications for general purpose Visual Display Units (VDUs), and in particular for VDUs to be used in telephone directory services and similar computer supported customer services. For VDUs based on Cathode Ray Tube technology, a rationale is presented for ergonomic requirements such as dark characters on a light background, a minimum refresh rate of 70 Hz, limits for acceptable levels of electric and magnetic field strengths, and full tilt, swivel and height adjustability of the VDU. Standardized measurement methods for e.g. legibility and resolution are needed in further developing the ergonomic procure ment process.     

A discussion of model accuracy in system identification

Model quality and model accuracy are of prime interest in system identification. In this contribution we will review and discuss these concepts. In particular we will split model errors into contributions from a ‘random error’ and a ‘bias error’ and describe and discuss how to assess these two concepts.     

Optimal Estimation of Rational Feedforward Control via Instrumental Variables: With Application to a Wafer Stage

Iterative control enables a significant control performance enhancement by learning feedforward command signals from previous tasks in a batch‐to‐batch fashion. The aim of this paper is to develop an approach to estimate the parameters of rational feedforward controllers that provide high performance and extrapolation capabilities towards varying tasks. An instrumental variable‐based algorithm is developed that leads to unbiased parameter estimates and optimal accuracy in terms of variance. Furthermore, a noncausal implementation of rational feedforward controllers is proposed, aiming to improve performance by means of pre‐actuation. Simulation and experimental results are presented to confirm that optimal accuracy is obtained with the proposed approach, and show the advantages of pre‐actuation in terms of performance.