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101.
Transforming growth factor-beta (TGF-beta) is a potent regulator of cell growth and differentiation. On the basis of the crystal structure of TGF-beta 2, we have designed and synthesized two mutant TGF-beta s, TGF-beta 1 (71 Trp) and TGF-beta 1 (delta 69-73). Although both of these molecules inhibited the growth of Mv1Lu mink lung epithelial cells and LS1034 colorectal cancer cells, which are affected equally by TGF-beta 1 and TGF-beta 2, TGF-beta 1 (delta 69-73) was much less potent than TGF-beta 1 or TGF-beta 1 (71 Trp) at inhibiting the growth of LS513 colorectal cancer cells which are growth-inhibited by TGF-beta 1 but not TGF-beta 2. Both TGF-beta 1 (71 Trp) and TGF-beta 1 (delta 69-73) increased levels of mRNAs for fibronectin and plasminogen activator inhibitor with Mv1Lu cells, whereas only TGF-beta 1 (71 Trp) and not TGF-beta 1 (delta 69-73) up-regulated the mRNA level of carcinoembryonic antigen in LS513 cells. The expression level of carcinoembryonic antigen mRNA in LS1034 cells was not altered by either wild-type or mutant TGF-beta s. Receptor labeling experiments demonstrated that TGF-beta 1 (71 Trp) bound with high affinity to the cell-surface receptors of Mv1Lu, LS1034, and LS513 cells while TGF-beta 1 (delta 69-73) bound effectively to the receptors of Mv1Lu and LS1034 cells but much less to the receptors on LS513 cells.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   
102.
Risk factors for severe acute asthma involve the patient, the environment and the society in general. In addition, there are strong interrelationships between these factors. Personal characteristics linked to acute severe asthma include age (teenagers), denial leading to poor compliance, depression with atypical symptoms in children, and some medical features of asthma associated with increased severity. Environmental factors include airborne allergens, infections, irritants such as air pollutants and passive smoking. Life events have not been extensively studied but are likely to play a predominant role. The social setting, particularly the health care system, acts as an interface between the patient and the environment. Most all asthma deaths are avoidable and related to dysfunctions in the health care system.  相似文献   
103.
BaTiO3 multilayer capacitors with a nominal capacitance of 3.5nF have been carefully measured using the thermally stimulated current (TSC) technique. When a 300V polarization voltage is applied at room temperature, a new TSC peak appeared in defective sample A after it has been immersed in water. No new peak was found in good-quality sample B after a similar treatment. The accelerated life test shows that sample A hasa much shorter life than sample B in terms of insulation resistance.  相似文献   
104.
用扫描电镜测定了含0.041%~0.076%RE的低碳Mn-Nb-RE钢中硫化物的成分、大小和形貌。RE/S值为2.8~3.0时,钢中的硫化物充分变质。  相似文献   
105.
本文为了克服精馏塔静态仿真不易收敛和初值难以给定等难题,巧妙地利用隐含数值积分方法的特点,将稳态与动态数学模型耦合起来,用以求解高难度的非理想精馏塔静态仿真问题。所得静动态混俣模型大大提高了精馏塔静态仿真的鲁棒性,对于高度非理想精馏塔的仿真尤为有效。通过对某丙烯腈萃取精馏塔的静态仿真,充分证明了这种混合模型化方法的可行性。  相似文献   
106.
山洪灾害预警准确度与及时度研究   总被引:1,自引:0,他引:1  
山洪灾害预警准确度与及时度是一对相互矛盾而又联系的重要指标。文章通过对这两项指标的研究和对引发灾害的降雨强度、降雨以及灾害发生的时间资料进行分析,从而获取预警系统建设的基本技术要点和参数,对把握山洪灾害预警系统的设计定位、启用时机和作用评估具有重要作用和意义。  相似文献   
107.
Sun  G. 《Electronics letters》2005,41(8):468-469
An optical approach is demonstrated for suppressing low-frequency relative intensity noise (RIN) transfer from pump sources to the author's proposed Raman fibre laser (RFL). Low-frequency RIN transfer suppression is accomplished by outputting not the second- but first-order Stokes, which output power is clamped by the lasing second-order Stokes in the cavity and can be easily tuned in a large dynamic range. Thus, this technique fits the RFL for use as pump sources in Raman fibre amplifiers.  相似文献   
108.
The radiation of millimeter waves from the nonradiative dielectric (NRD) leaky wave antennas with the tapered transition and the tuning aperture is investigated. An accurate theory for the leakage constant and the phase constant of the antennas is presented, which is based on the generalized scattering parameters considering the higher-order mode interactions at the discontinuities. The associated transverse equivalent network involves the characterization of the mode couplings at two air-to-dielectric interfaces, the coupled mode analysis of the tapered transition, and the calculation of the radiation fields at the tuning aperture via the extended spectral domain approach. The interesting behavior of the present modified configuration of NRD leaky wave antennas is illustrated by typical examples. The validity of the theory is confirmed by the comparison of the theoretical results with experimental data for the limiting cases  相似文献   
109.
In this work, we present three different formulations, namely the pressure field integral equation formulation (PFIE), the velocity field integral equation formulation (VFIE), and the combined field integral equation formulation (CFIE) for solving acoustic scattering problems associated with two-dimensional fluid-filled bodies of arbitrary cross-section. In particular using the boundary conditions on the surface of the body, two equivalent problems, each valid for the outside and inside regions of the scatterer, are derived. By properly selecting the associated equations for these equivalent problems, the three different formulations are derived. The PFIE, VFIE, and CFIE are then solved by approximating the cylindrical cross-section by linear segments and employing the method of moments. Further, it is shown that the moment matrices generated by the PFIE and VFIE are ill-conditioned at resonant frequencies of the cylinder, whereas the CFIE generates a well-conditioned matrix at all frequencies. The solution techniques presented in this work are simple, efficient and applicable to truly arbitrary geometries. Numerical results are presented for certain canonical shapes and compared with other available data.  相似文献   
110.
Parallel multi-inverter systems can be designed to have the advantages of expandable output power, improved reliability, and easy N+X redundancy operation. However, a current-sharing control scheme has to be employed to enable the inverters to share the load current equally. A multi-inverter system with instantaneous average-current-sharing scheme is presented in this paper. By introducing a disturbance source to represent all the sources that may cause current unbalances, a model of the system can be built. Some key issues are discussed based on the model, including stability of the current-sharing controller, impedance characteristics and voltage regulation. Three experimental 110 VAC/1.1 kVA inverters are built and paralleled to verify the theoretical predictions.  相似文献   
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