Depressive manifestations and differential patterns of treatment outcome in an intensive partial hospitalization treatment program.

Patients with personality disorder demonstrate heterogeneity in symptom presentation and treatment needs. Methods of subtyping patient presentations may illuminate important patient-treatment matches. Previous studies of an intensive partial hospitalization approach for patients with affective and personality disorders had demonstrated significant treatment effects. The current study aimed at identifying differential patterns of treatment engagement and outcome within this context of substantial aggregate benefit. Our sample was comprised of 107 outpatients, all of whom presented with Diagnostic and Statistical Manual of Mental Disorders (4th ed., American Psychiatric Association, 1994) Axis II traits or full disorders. In a prior cluster analysis, measures of depressive symptom manifestation were employed to identify four distinct patient subgroups. The cluster designation was tested as an independent factor influencing in-treatment ratings (well-being, anxiety, depression) and pre- to posttreatment ratings of outcome. The patient clusters showed significantly different patterns of change in anxiety (slopes) over the course of treatment. Significant differences between clusters were also evident in the proportion of patients achieving clinically significant change on 3 central outcome indexes. Results are considered in terms of the match between the patient’s clinical presentation (e.g., anaclitic depression) and the treatment approach, with attention to implications for patient selection and preparation for the partial hospital program. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structure‐Specific Recognition of Friedreich's Ataxia (GAA)n Repeats by Benzoquinoquinoxaline Derivatives

Expansion of GAA triplet repeats in intron 1 of the FXN gene reduces frataxin expression and causes Friedreich's ataxia. (GAA)_n repeats form non‐B‐DNA structures, including triple helix H‐DNA and higher‐order structures (sticky DNA). In the proposed mechanisms of frataxin gene silencing, central unanswered questions involve the characterization of non‐B‐DNA structure(s) that are strongly suggested to play a role in frataxin expression. Here we examined (GAA)_n binding by triplex‐stabilizing benzoquinoquinoxaline (BQQ) and the corresponding triplex‐DNA‐cleaving BQQ‐1,10‐phenanthroline (BQQ‐OP) compounds. We also examined the ability of these compounds to act as structural probes for H‐DNA formation within higher‐order structures at pathological frataxin sequences in plasmids. DNA‐complex‐formation analyses with a gel‐mobility‐shift assay and sequence‐specific probing of H‐DNA‐forming (GAA)_n sequences by single‐strand oligonucleotides and triplex‐directed cleavage demonstrated that a parallel pyrimidine (rather than purine) triplex is the more stable motif formed at (GAA)_n repeats under physiologically relevant conditions.     

Hypercalcaemia in patients with newly diagnosed tuberculosis in Malaysia

A giant hidradenocarcinoma presented by a 75-year-old female is reported. The patient had a malignant transformation within a nodular hidradenoma involving the right postauricular area, which was treated by mass removal and a right radical neck dissection with a free-flap covering. Malignant hidradenocarcinoma is the least common adnexal tumor of uncertain origin. They are usually malignant from their inception, but some develop from a benign counterpart. To the authors' knowledge, only three cases have been reported previously. Two histologically distinct components were seen in this tumor: (i) typical nodular hidradenoma, which constituted a small part of the tumor; and (ii) carcinoma with areas of transition. The secretory cells of hidradenocarcinoma showed decapitation secretion on light and electron microscopic observations, which is evidence of apocrine differentiation. Histologically, this case was concluded as a hidradenocarcinoma arising from a long-standing nodular hidradenoma. A literature review is presented and the histological, immunohistochemical and ultrastructural features are described.     

Cor pulmonale due to obstructive sleep apnoea

A 47 year old man with a long history of chronic loud snoring and daytime sleepiness presented with hypercapnic respiratory failure and right ventricular failure. The diagnosis of obstructive sleep apnoea (OSA) leading to the 'obesity-hypoventilation syndrome', was supported by the findings of an overnight cardio-respiratory monitoring during sleep. His symptoms and arterial blood gases improved following treatment with nocturnal nasal continuous positive airway pressure (CPAP).     

Molecular self-assembly into one-dimensional nanostructures

Self-assembly of small molecules into one-dimensional nanostructures offers many potential applications in electronically and biologically active materials. The recent advances discussed in this Account demonstrate how researchers can use the fundamental principles of supramolecular chemistry to craft the size, shape, and internal structure of nanoscale objects. In each system described here, we used atomic force microscopy (AFM) and transmission electron microscopy (TEM) to study the assembly morphology. Circular dichroism, nuclear magnetic resonance, infrared, and optical spectroscopy provided additional information about the self-assembly behavior in solution at the molecular level. Dendron rod-coil molecules self-assemble into flat or helical ribbons. They can incorporate electronically conductive groups and can be mineralized with inorganic semiconductors. To understand the relative importance of each segment in forming the supramolecular structure, we synthetically modified the dendron, rod, and coil portions. The self-assembly depended on the generation number of the dendron, the number of hydrogen-bonding functions, and the length of the rod and coil segments. We formed chiral helices using a dendron-rod-coil molecule prepared from an enantiomerically enriched coil. Because helical nanostructures are important targets for use in biomaterials, nonlinear optics, and stereoselective catalysis, researchers would like to precisely control their shape and size. Tripeptide-containing peptide lipid molecules assemble into straight or twisted nanofibers in organic solvents. As seen by AFM, the sterics of bulky end groups can tune the helical pitch of these peptide lipid nanofibers in organic solvents. Furthermore, we demonstrated the potential for pitch control using trans-to-cis photoisomerization of a terminal azobenzene group. Other molecules called peptide amphiphiles (PAs) are known to assemble in water into cylindrical nanostructures that appear as nanofiber bundles. Surprisingly, TEM of a PA substituted by a nitrobenzyl group revealed assembly into quadruple helical fibers with a braided morphology. Upon photocleavage of this the nitrobenzyl group, the helices transform into single cylindrical nanofibers. Finally, inspired by the tobacco mosaic virus, we used a dumbbell-shaped, oligo(phenylene ethynylene) template to control the length of a PA nanofiber self-assembly (<10 nm). AFM showed complete disappearance of long nanofibers in the presence of this rigid-rod template. Results from quick-freeze/deep-etch TEM and dynamic light scattering demonstrated the templating behavior in aqueous solution. This strategy could provide a general method to control size the length of nonspherical supramolecular nanostructures.     

Development of a Novel Ni-Based Multi-principal Element Alloy Filler Metal,Using an Alternative Melting Point Depressant

Brazing is a crucial joining technology in industries where nickel-superalloy components must be joined. Nickel-based brazing filler metals are extensively employed, possessing excellent mechanical properties, corrosion resistance, and retained strength at elevated temperatures. To function as a filler metal, the alloy melting point must be reduced to below that of the materials being joined, but the addition of melting point depressants (MPDs) such as boron, silicon, and phosphorus can, however, lead to the formation of brittle intermetallics, potentially compromising the joint performance. In the present work, a novel multi-principal element brazing alloy (in the style of a high entropy alloy), utilizing Ge as an alternative MPD along with a reduced B addition, is investigated. The design process considered binary phase diagrams and predictions based on Thermo-Calc software and empirical thermodynamic parameters. The alloy was used to vacuum braze nickel-superalloy Inconel-718, and microstructural and mechanical investigations are reported. The maximum shear strength achieved was 297 MPa with a brazing temperature of 1100 °C and 60-minute hold time, with isothermal solidification completed. Shear strength was only slightly reduced with increased joint width. Assessments are made of the ability to accurately predict properties of multi-principle element alloys using Thermo-Calc software and empirical thermodynamic parameters.

     

Justification for the selection of manufacturing technologies: a fuzzy-decision-tree-based approach

In this paper, a developed model for the justification of alternative manufacturing technologies is presented. The approach, based on fuzzy decision trees, provides a methodology capable of identifying patterns within a technology case repository to support the evaluation of manufacturing systems. Experts are highly influential individuals in the decision process; they provide support and guidance when selecting investments. The experience-oriented task is founded on previous cases or an experts’ experience, and therefore difficult to express in a rational form. The concept is based on a number of characteristics of the case-based reasoning, rule induction and expert system theory. Structured around the fuzzy-decision-tree data-mining technique, the framework provides the ability of using regulated case information to act as structured experience for assisting in the decision process. Fuzzy induction extracts formal rules from a set of experience data, and the expert system philosophy computes the experience base of human expertise for problem-solving. A test case indicates the stability of the classification algorithm and verifies the applicability within the domain.     

Brave New Now

Under Tomorrow's Sky is a fictional future city. For the project, speculative architect Liam Young assembled a think-tank of scientists, technologists, futurists, illustrators and science-fiction authors to collectively develop this imaginary place, the landscapes that surround it and the stories it contains. The city forms a stage set for a collection of fictions, emerging infrastructures and design experiments. It is an imaginary landscape extrapolated from the wonders and possibilities of emerging biological and technological research. Here, speculative fiction provides a critical tool, which is visionary in its trajectory while provoking us to examine some of the most pertinent questions facing us today.     

A Distributed Ground: The Unknown Fields Division

As leaders of the Unknown Fields Division at the Architectural Association (AA) School of Architecture in London, Liam Young and Kate Davies take their students on trips to the end of the earth. Cataloguing extreme territories, they investigate the role of design in developing new cultural relationships. Fictional speculation is used as an instrument for understanding emerging environmental and technological futures, in a process of experiencing, chronicling and, ultimately, reimagining the urban and the remote, and charting global flows and trajectories. Here they describe a speculative supply chain that begins below the surface of the Western Desert in outback Australia, and continues to the Arctic ‘Northwest Passage’ and on to London.