Investigation into the influence of direct current (DC) power in the magnetron sputtering process on the copper crystallite size

This paper discusses the influence of direct current (DC) power in the magnetron sputtering process on the crystallite size of the copper (Cu) thin films deposited on p-type silicon substrate at room temperature. X-ray diffraction (XRD) and Karl Suss four-point probe were employed to study the film crystallinity and conductivity, respectively. From the analysis on the XRD patterns, high DC power enhances the Cu film crystallinity with larger crystallite size, which is deduced using Sherrer's formula. The behavior of the electrical property of the Cu films complies with the trend of the film crystallinity with DC power, in which the film conductivity increases with increasing DC power. We attribute these phenomena to the enhanced surface diffusion mechanism of the adatom during the sputtering deposition process, which improves the microstructure of the Cu film.     

Modification of polypropylene filter with metal oxide and reduced graphene oxide for water treatment

A hydrothermal method for the synthesis of reduced graphene oxide/titanium dioxide filter (RGO/TiO₂) and reduced graphene oxide/zinc oxide filter (RGO/ZnO) by using polypropylene (PP) porous filter is reported. Field emission scanning electron microscopy illustrated that the nanoparticles were uniformly distributed on the reduced graphene oxide nanosheets. Flexural tests showed that the physical properties of the modified filters have greater strength than the original filter. Thermogravimetric analysis revealed that the thermal property of the modified filters is the same as that of the original filter. Under a halogen lamp, the modified filter exhibited excellent photocatalytic degradation of methylene blue. The RGO/TiO₂ filter maintained its ability to degrade MB efficiently, even after five cycles of photocatalysis.     

A biomimetic approach to enhancing interfacial interactions: polydopamine-coated clay as reinforcement for epoxy resin

A facile biomimetic method was developed to enhance the interfacial interaction in polymer-layered silicate nanocomposites. By mimicking mussel adhesive proteins, a monolayer of polydopamine was constructed on clay surface by a controllable coating method. The modified clay (D-clay) was incorporated into an epoxy resin, it is found that the strong interfacial interactions brought by the polydopamine benefits not only the dispersion of the D-clay in the epoxy but also the effective interfacial stress transfer, leading to greatly improved thermomechanical properties at very low inorganic loadings. Rheological and infrared spectroscopic studies show that the interfacial interactions between the D-clay and epoxy are dominated by the hydrogen bonds between the catechol-enriched polydopamine and the epoxy.     

A Pulsed NMR Method for the Study of Starch Retrogradation

A rapid and non-destructive pulsed NMR method of monitoring starch retrogradation was developed based on the principle that the signals from protons in the “solid-like” and liquid components in a system decay at significantly different rates following a 90° radio-frequency pulse. As molecular association or recrystallization proceeds during aging of a starch gel, the proportion of the “solid-like” component in the system increases. The resulting decrease in segmental mobility of the starch chains causes a decrease in the signal from the liquid component, but a concomitant increase in the signal attributed to protons in the “solid-like” fraction. The method was applied to study the retrogradation tendency of starches from different botanical sources.     

Design process knowledge for crisis-driven information systems solutions: Insights on building digital resilience from an action design research study

As global disruptions escalate, digital resilience (DR)—the capacity to anticipate, absorb, and adapt to external shocks by leveraging Information Systems (IS)—has become crucial for individuals and organisations confronting and managing unprecedented crises. This research advances understanding on how to develop DR, drawing on insights from an Action Design Research (ADR) study conducted during the COVID-19 pandemic. Our research explores a particular facet of DR: the capacity to manage exogenous shocks through the design  of new IS solutions. We introduce the ADAPT framework, comprising five key enablers—Agility, Designation, Alignment, Participation, and Trust—recommended to support design teams developing IS solutions during and for crises. Our ADR project, which resulted in the creation of a telemonitoring system used by over 115 frontline healthcare workers to monitor the symptoms of more than 1000 COVID-19 patients, demonstrates the instrumental role these five enablers play in supporting a crisis-propelled IS design process that is urgent, resource-limited, and multi-partite. By presenting new design process knowledge and practical recommendations that guide crisis-driven IS design, we aim to equip design teams with the understanding they need to effectively navigate similar challenges in the future. We also hope to inspire and support IS researchers to apply their expertise in the design, deployment, and use of IS solutions to contribute to crisis-driven design endeavours that tackle the pressing and urgent challenges of our time.     

Discovery of Potent Inhibitors of Cyclin-Dependent Kinases 7 and 9: Design,Synthesis, Structure-Activity Relationship Analysis and Biological Evaluation

Cyclin-dependent kinases (CDKs) 7 and 9 are deregulated in various types of human cancer and are thus viewed as therapeutic targets. Accordingly, small-molecule inhibitors of both CDKs are highly sought-after. Capitalising on our previous discovery of CDKI-73, a potent CDK9 inhibitor, medicinal chemistry optimisation was pursued. A number of N-pyridinylpyrimidin-2-amines were rationally designed, chemically synthesised and biologically assessed. Among them, N-(6-(4-cyclopentylpiperazin-1-yl)pyridin-3-yl)-4-(imidazo[1,2-a]pyrimidin-3-yl)pyrimidin-2-amine was found to be one of the most potent inhibitors of CDKs 7 and 9 as well as the most effective anti-proliferative agent towards multiple human cancer cell lines. The cellular mode of action of this compound was investigated in MV4-11 acute myeloid leukaemia cells, revealing that the compound dampened the kinase activity of cellular CDKs 7 and 9, arrested the cell cycle at sub-G1 phase and induced apoptosis.