Alternate-Day Fasting Ameliorates Newly Established Sjögren’s Syndrome-like Sialadenitis in Non-Obese Diabetic Mice

Intermittent fasting confers protections to various diseases including autoimmune disorders, but the specific effects of intermittent fasting on Sjögren’s syndrome (SS) remains inconclusive. The present study was undertaken to determine the specific impact of alternate-day fasting (ADF) on newly established SS-like sialadenitis using non-obese diabetic (NOD) mice. Female NOD mice were deprived of food every other day from 10 to 13 weeks of age, the early stage of established SS, and then analyzed for the disease characteristics. Mice in the ADF group had higher salivary flow rate and attenuated submandibular gland (SMG) inflammation, compared to the control mice fed with standard chow ad libitum. The improvements were accompanied with a decrease in the total leukocytes, T and B lymphocytes and activated CD4 and CD8 T cells, and a down-regulation of pro-inflammatory cytokines IFN-γ and IL-17, chemokine receptor CXCR3 and its ligands CXCL9 and CXCL11 in the SMGs. ADF also led to elevated mRNA levels of water channel protein aquaporin 5 and tight junction protein claudin-1, two factors crucial for normal salivary secretion in the SMGs. In addition, ADF reduced the proportion of IFN-γ- and IL-17- expressing CD4 T cells and diminished mRNA levels of IFN-γ, TNF-α, and IL-17 in the total submandibular draining lymph node cells. Taken together, ADF is effective in ameliorating newly established SS-associated salivary gland exocrinopathy in NOD mice.     

Cryogenic 3D Printing of w/o Pickering Emulsions Containing Bifunctional Drugs for Producing Hierarchically Porous Bone Tissue Engineering Scaffolds with Antibacterial Capability

How to fabricate bone tissue engineering scaffolds with excellent antibacterial and bone regeneration ability has attracted increasing attention. Herein, we produced a hierarchical porous β-tricalcium phosphate (β-TCP)/poly(lactic-co-glycolic acid)-polycaprolactone composite bone tissue engineering scaffold containing tetracycline hydrochloride (TCH) through a micro-extrusion-based cryogenic 3D printing of Pickering emulsion inks, in which the hydrophobic silica (h-SiO₂) nanoparticles were used as emulsifiers to stabilize composite Pickering emulsion inks. Hierarchically porous scaffolds with desirable antibacterial properties and bone-forming ability were obtained. Grid scaffolds with a macroscopic pore size of 250.03 ± 75.88 μm and a large number of secondary micropores with a diameter of 24.70 ± 15.56 μm can be fabricated through cryogenic 3D printing, followed by freeze-drying treatment, whereas the grid structure of scaffolds printed or dried at room temperature was discontinuous, and fewer micropores could be observed on the strut surface. Moreover, the impartment of β-TCP in scaffolds changed the shape and density of the micropores but endowed the scaffold with better osteoconductivity. Scaffolds loaded with TCH had excellent antibacterial properties and could effectively promote the adhesion, expansion, proliferation, and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells afterward. The scaffolds loaded with TCH could realize the strategy to “kill bacteria first, then induce osteogenesis”. Such hierarchically porous scaffolds with abundant micropores, excellent antibacterial property, and improved bone-forming ability display great prospects in treating bone defects with infection.     

湖北城市建设职业技术学院藏龙岛校区设计构想

该文从设计理念、空间特色及单体建筑设计的几个方面,简要地介绍了湖北城市建设职业技术学院藏龙岛校区的设计构思。     

浅议日本小学开放式教学空间的设计思想

文章简要回顾了日本小学教育的发展历史,并且根据日本小学教育的情况,分析了其教学空间设计的几个特点。     

浅谈教育建筑综合体-以广州中匮药大学国际楼为例

当前校园规划出现了复杂性导向,在校园规划的发展过程中,建筑单体也出现了混合功能的倾向.该文就此倾向进行剖析,并结合广州中医药大学国际楼实际工程提出教育建筑综合体的设计特点.     

用于短波红外探测器的微透镜阵列制作

采用光刻胶热熔法制作具有特定尺寸的微透镜,制作的微透镜能将微透镜阵列技术应用于短波1 μm ~3 μm红外探测器中,有效地提高探测器件的光电性能。采用AZ P4620厚光刻胶,利用紫外光刻技术,对透镜制作中的前烘、曝光和显影、坚膜、热熔等工艺进行了深入细致的实验研究,确定了最优的工艺参数,实现了球冠直径在(5.5±0.5) μm,曲率半径3 μm的微透镜,且透镜有很好的均匀性和一致性,满足近红外探测器件的要求。     

常带宽服务器混合任务低功耗调度算法

针对包含有截止期限限制的周期任务和有响应时间要求的非周期任务的实时系统混合任务集,提出常带宽服务器混合任务低功耗调度算法(constant bandwidth server mix task low power scheduling algorithm, CBSMTLPSA).该算法是2阶段调度算法,并且结合了动态电压调节(dynamic voltage scaling, DVS)技术和动态功耗管理(dynamic power management, DPM)技术.离线阶段确定任务的离线速度,充分利用处理器的资源;在线阶段通过回收周期任务提早完成的空闲时间以及服务器产生的空闲时间,利用DVS技术调节处理器的运行速度,并且当处理器处于空闲状态时,判断是否使用DPM技术以达到进一步降低能耗的目的.仿真实验表明所提出的CBSMTLPSA算法比CBS/DRA-W(constant bandwidth server for dynamic reclaim algorithm base workload)算法节约6.02%～34.14%的能耗;CBSMTLPSA算法的能耗与非周期任务的响应时间的乘积比CBS/DRA-W算法低5.86%～34.06%.     

Direct Ink Writing of Highly Conductive MXene Frames for Tunable Electromagnetic Interference Shielding and Electromagnetic Wave?Induced Thermochromism

The highly integrated and miniaturized next-generation electronic products call for high-performance electromagnetic interfer?ence (EMI) shielding materials to ...     

Interfacial Phase in Ti-5Al-2Mo-3Zr Alloy

Under appropriate cooling condition, intcrfacial phase appeared between α and β phases in Ti-5Al-2M0-3Zr alloy. Its thickness could reach 100 nm. The interfacial phase was either single layer structure or double layer structure. The monolithic layer adjacent to 3 phase was indentified as fee structure with relationship （110）_β// （001）_m, [11$\\mathop 1\\limits^{{\\rm{ - - }}} $]_β /[110]_m. The striated layer adjacent to a phase was indentified as hep with twin relationship {10$\\bar 1$1}<1$\\bar 0$12> to α. Thus, the study provided a new experimental fact for the controversial topic on structure of striated layer. Chemical composition of interfacial phase varied slightly with heat treatments, but always between that of α and β phases.