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排序方式: 共有137条查询结果,搜索用时 15 毫秒
71.
Isabelle E. François Dr. Karin Thevissen Dr. Klaartje Pellens Dr. Els M. Meert Jan Heeres Dr. Eddy Freyne Dr. Erwin Coesemans Dr. Marcel Viellevoye Dr. Frederik Deroose Dr. Sonia Martinez Gonzalez Dr. Joaquin Pastor Dr. David Corens Dr. Lieven Meerpoel Dr. Marcel Borgers Dr. Jannie Ausma Dr. Gerrit D. Dispersyn Dr. Bruno P. Cammue Prof. Dr. 《ChemMedChem》2009,4(10):1714-1721
In this study, we screened a library of 500 compounds for fungicidal activity via induction of endogenous reactive oxygen species (ROS) accumulation. Structure–activity relationship studies showed that piperazine‐1‐carboxamidine analogues with large atoms or large side chains substituted on the phenyl group at the R3 and R5 positions are characterized by a high ROS accumulation capacity in Candida albicans and a high fungicidal activity. Moreover, we could link the fungicidal mode of action of the piperazine‐1‐carboxamidine derivatives to the accumulation of endogenous ROS. 相似文献
72.
The inoculum effect on the ammonia-oxidizing bacterial communities in parallel sequential batch reactors 总被引:1,自引:0,他引:1
Lieven Wittebolle 《Water research》2009,43(17):4149-4158
Three identical sequential batch reactors (SBRs) were each inoculated with sludge from a full-scale wastewater treatment plant (WWTP) treating a waste stream of different origin, i.e. a hospital, a meat processing company, and a municipal WWTP. The SBRs were run in parallel for 84 consecutive days to investigate whether the reactors would become more phylogenetically similar or stay separated concerning their functionality and microbial communities. Overall, the nitrification functionality was high throughout the experiment, and the size and structure of the sludge flocs were very similar. The total bacterial and ammonia-oxidizing bacterial (AOB) communities were analyzed by PCR-DGGE. Cluster analysis demonstrated very distinct bacterial communities in the three SBRs, not showing any trend becoming more similar. The carrying capacity, dynamics and functional organization of the communities were assessed by DGGE analysis and based on these patterns the range-weighted richness, moving window analysis, and constructing Pareto-Lorenz evenness distribution curves were calculated. Between the SBRs, highly comparable internal structure and dynamics of the AOB communities were observed, although they had only one AOB DGGE band in common. These observations indicate that community characteristics such as the extent of biodiversity and dynamics are more important indicators of good microbial functionality than the presence of certain specific species. 相似文献
73.
Thomas Eekhout Jos Antonio Pedroza-Garcia Pooneh Kalhorzadeh Geert De Jaeger Lieven De Veylder 《International journal of molecular sciences》2021,22(17)
During DNA replication, the WEE1 kinase is responsible for safeguarding genomic integrity by phosphorylating and thus inhibiting cyclin-dependent kinases (CDKs), which are the driving force of the cell cycle. Consequentially, wee1 mutant plants fail to respond properly to problems arising during DNA replication and are hypersensitive to replication stress. Here, we report the identification of the polα-2 mutant, mutated in the catalytic subunit of DNA polymerase α, as a suppressor mutant of wee1. The mutated protein appears to be less stable, causing a loss of interaction with its subunits and resulting in a prolonged S-phase. 相似文献
74.
Lieve Okerman Herlinde Noppe Vanessa Cornet Lieven De Zutter 《Food Additives & Contaminants》2007,24(3):252-257
To assess if microbiological inhibition tests for detection of antibiotic residues are suitable for routine screening for quinolone residues, the limit of detection (LOD) of 10 different quinolones and fluoroquinolones was determined. Two media were tested, one at pH 6 and the other at pH 8, each seeded with one of the following test strains: Bacillus subtilis, Escherichia coli or Bacillus cereus. LODs of the 10 substances were highest on plates seeded with B. cereus, intended for selective detection of tetracycline residues. The pattern of zones on the other four plates differed for the targeted quinolones: flumequine and oxolinic acid were detected at lower concentrations at pH 6, while the LODs of ciprofloxacin, enrofloxacin, danofloxacin, marbofloxacin, sarafloxacin and norfloxacin were lower at pH 8. Nine of the 10 quinolones were detected more easily with E. coli, but the LOD of difloxacin was lower with B. subtilis. Finally, the three most sensitive media were selected and fluid from chicken meat, spiked with eight quinolones near maximum residue limits (MRL), analysed on each plate. The plate seeded with E. coli at pH 8 detected five of eight quinolones at levels of interest, but an additional E. coli plate at pH 6 was necessary for detection of flumequine in species other than poultry and fish. None of the plates detected oxolinic acid and difloxacin at MRLs in muscle tissue. 相似文献
75.
Farrar CR Lieven NA 《Philosophical transactions. Series A, Mathematical, physical, and engineering sciences》2007,365(1851):623-632
This paper concludes the theme issue on structural health monitoring (SHM) by discussing the concept of damage prognosis (DP). DP attempts to forecast system performance by assessing the current damage state of the system (i.e. SHM), estimating the future loading environments for that system, and predicting through simulation and past experience the remaining useful life of the system. The successful development of a DP capability will require the further development and integration of many technology areas including both measurement/processing/telemetry hardware and a variety of deterministic and probabilistic predictive modelling capabilities, as well as the ability to quantify the uncertainty in these predictions. The multidisciplinary and challenging nature of the DP problem, its current embryonic state of development, and its tremendous potential for life-safety and economic benefits qualify DP as a 'grand challenge' problem for engineers in the twenty-first century. 相似文献
76.
Lieven Meerpoel Dr. Jan Heeres Dr. Leo J. J. Backx Louis J. E. Van der Veken Rob Hendrickx David Corens Dr. Alex De Groot Dr. Stef Leurs Dr. Luc Van der Eycken Johan Weerts Paul Luyts Frans Van Gerven Filip A. A. Woestenborghs Andre Van Breda Michel Oris Pascal van Dorsselaer Gustaaf H. M. Willemsens Danny Bellens Patrick J. M. G. Marichal Dr. Hugo F. Vanden Bossche Frank C. Odds Prof. 《ChemMedChem》2010,5(5):757-769
Herein we describe the scalable diastereoselective and enantioselective syntheses of eight enantiomers of hydroxy metabolites of saperconazole. The in vitro antifungal activity of the eight stereoisomers (compounds 1 – 8 ) was compared against a broad panel of Candida spp. (n=93), Aspergillus spp. (n=10), Cryptococcus spp. (n=19), and dermatophytes (n=27). The four 2S isomers 1 – 4 of the new agent were generally slightly more active than the four 2R isomers 5 – 8 . All eight isomers were tested in a model of experimental A. fumigatus infection in guinea pigs by intravenous inoculation of the fungal conidia. Treatment doses were 1.25 mg kg?1 and 2.5 mg kg?1 per day. Infection severity was measured in terms of mean survival time (MST) after infection and mean tissue burdens in brain, liver, spleen, and kidney at postmortem examination. Among the eight isomers, the 2S diastereomers 1 – 4 showed a generally higher level of activity than the 2R diastereomers 5 – 8 , revealing compounds 1 and 4 as the most potent overall in eradicating tissue burden and MST. Compared with reference compounds itraconazole and saperconazole, the hydroxy isomers 1 – 8 are less potent inhibitors of the growth of A. fumigatus in vitro and of ergosterol biosynthesis in both A. fumigatus and C. albicans. 相似文献
77.
78.
Can Acid Volatile Sulfides (AVS) Influence Metal Concentrations in the Macrophyte Myriophyllum aquaticum? 总被引:1,自引:0,他引:1
J Teuchies M De Jonge P Meire R Blust L Bervoets 《Environmental science & technology》2012,46(16):9129-9137
The difference between the molar concentrations of simultaneously extracted metals (SEM) and acid volatile sulfides (AVS) is widely used to predict metal availability toward invertebrates in hypoxic sediments. However, this model is poorly investigated for macrophytes. The present study evaluates metal accumulation in roots and stems of the macrophyte Myriophyllum aquaticum during a 54 day lab experiment. The macrophytes, rooting in metal contaminated, hypoxic, and sulfide rich field sediments were exposed to surface water with 40% or 90% oxygen. High oxygen concentrations in the 90% treatment resulted in dissolution of the metal-sulfide complexes and a gradual increase in labile metal concentrations during the experiment. However, the general trend of increasing availability in the sediment with time was not translated in rising M. aquaticum metal concentrations. Processes at the root-sediment interface, e.g., radial oxygen loss (ROL) or the release of organic compounds by plant roots and their effect on metal availability in the rhizosphere may be of larger importance for metal accumulation than the bulk metal mobility predicted by the SEM-AVS model. 相似文献
79.
LievenVangheluwe 《上海纺织科技》2003,31(6):57-59
纱线气流指数仪是一种类似喷气织机引纬系统脱机操作的测试装置,用于测试喷气织造纬纱的速度(平均值和变异系数)。文章综述了诸如纱线气流指数与喷气织机耗气量、织机速度之间的关系等,同时还介绍了会对纱线气流指数值产生影响的某些纱线品质。 相似文献
80.
Independent Component Analysis (ICA) aims at blindly decomposing a linear mixture of independent sources. It has lots of applications in diverse research areas. In some applications, there is prior knowledge on the sources and/or the mixing vectors. This prior knowledge can be incorporated in the computation of the independent sources. In this paper we provide an algorithm for so-called spatially constrained ICA (scICA). The algorithm deals with the situation when one mixing vector is exactly known. Also the generalization to more mixing vectors is discussed. Numerical experiments are reported that allow us to assess the improvement in accuracy that can be achieved with these algorithms compared to fully blind ICA and to a previously proposed constrained algorithm. We illustrate the approach with a biomedical application. 相似文献