Biomedical applications of mRNA nanomedicine

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.     

汽车铸件生产工时数理统计计算方法

采用多元非线性回归分析方法 ,对我国汽车铸造生产管理数据进行微机辅助分析 ,得出了铸件生产工时计算公式 ,编制了计算机辅助管理程序。     

基于多目视觉的变形钢板三维测量方法

提出了一种使用4个相机测量变形钢板三维形状的方法;在没有纹理的钢板上画一些点,使用4个相机同时拍摄钢板;利用边缘检测算法找出钢板的边缘,利用特征点提取算法提取出4个图像中钢板上的特征点,并找到4个图像上精确的特征点匹配关系,然后测量出这些特征点的三维点;最后,以这些三维点为种子点向外区域增长,从而得到钢板的三维形状;实验对变形钢板进行三维测量,得到了钢板的精确的三维形状,结果验证了该方法的有效性和可行性。     

嵌入式水电气在线遥监控系统研究

该文介绍了一个基于CNA总线的嵌入式Web监控水、电、气在线遥控监控系统的架构方案,重点阐述其监控水、电、气管理系统的设计思路,对其中涉及的关键技术进行了较为详细的叙述。     

中职计算机技能大赛推进教学改革的研究

现在很多职业院校都参加了计算机技能大赛,如何通过技能大赛有效的推进职业教育教学改革,把在参加技能大赛中学习到的教学方法和经验有效的融入到日常教学改革中,是广大职业教育工作者急需面对和解决的一个问题。通过分析计算机技能大赛对计算机教学改革的推进作用,对中职计算机教学改革进行了研究。     

OpenCL: A Parallel Programming Standard for Heterogeneous Computing Systems

We provide an overview of the key architectural features of recent microprocessor designs and describe the programming model and abstractions provided by OpenCL, a new parallel programming standard targeting these architectures.     

一类多输入多输出系统的冗余设计

分析了多输入多输出多变量系统在某环节失效时系统的整体性,给出了针对开环传递函数矩阵以及解耦后新对象均为本质稳定对象时系统的冗余设计方法.该方法有效解决了某环节失效后对系统稳定性的影响,实现了复杂系统的容错控制.仿真结果表明,该冗余设计方法可行,能够实现系统的容错控制.     

Several multi-criteria programming methods for classification

In this paper, we propose a general optimization-based model for classification. Then we show that some well-known optimization-based methods for classification, which were developed by Shi et al. [Data mining in credit card portfolio management: a multiple criteria decision making approac. In: Koksalan M, Zionts S, editors. Multiple criteria decision making in the new millennium. Berlin: Springer; 2001. p. 427–36] and Freed and Glover [A linear programming approach to the discriminant problem. Decision Sciences 1981; 12: 68–79; Simple but powerful goal programming models for discriminant problems. European Journal of Operational Research 1981; 7: 44–60], are special cases of our model. Moreover, three new models, MCQP (multi-criteria indefinite quadratic programming), MCCQP (multi-criteria concave quadratic programming) and MCVQP (multi-criteria convex programming), are developed based on the general model. We also propose algorithms for MCQP and MCCQP, respectively. Then we apply these models to three real-life problems: credit card accounts, VIP mail-box and social endowment insurance classification. Extensive experiments are done to compare the efficiency of these methods.