Evaluating the Endophenotype Model of ADHD Neuropsychological Deficit: Results for Parents and Siblings of Children With ADHD Combined and Inattentive Subtypes.

Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/ hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Personalcasting: Tailored Broadcast News

Broadcast news sources and newspapers provide society with the vast majority of real-time information. Unfortunately, cost efficiencies and real-time pressures demand that producers, editors, and writers select and organize content for stereotypical audiences. In this article we illustrate how content understanding, user modeling, and tailored presentation generation promise personalcasts on demand. Specifically, we report on the design and implementation of a personalized version of a broadcast news understanding system, MITRE’s Broadcast News Navigator (BNN), that tracks and infers user content interests and media preferences. We report on the incorporation of Local Context Analysis to both expand the user’s original query to the most related terms in the corpus, as well as to allow the user to provide interactive feedback to enhance the relevance of selected newsstories. We describe an empirical study of the search for stories on ten topics from a video corpus. By personalizing both the selection of stories and the form in which they are delivered, we provide users with tailored broadcast news. This individual news personalization provides more fine-grained content tailoring than current personalized television program level recommenders and does not rely on externally provided program metadata.     

高强聚烯烃静态断裂过程银纹区的性能1.HDPE

为了观察分析高密度聚乙烯(HDPE)的银纹区性能,对两种HDPE全切痕试样分别进行了速率为0.1 mm/min,0.5 mm/min,1 mm/min,5 mm/min,20 mm/min和50 mm/min的拉伸测试。基于对静态断裂过程应力-位移数据的分析处理,结果表明,HDPE的屈服应力随着拉伸速率增大;高应力时两种HDPE均存在常临界位移控制其银纹断裂;HDPE2480银纹微纤的稳定性较大,材料韧性较好。HDPE静态拉伸断面显微结构显示,HDPE2480的银纹微纤尺寸大于HDPE4801,导致两者断面弧形巢尺寸和弧形巢内粗糙度的不同。     

国外制冷系统及压缩机技术的新动向

无论是提高系统的效率,还是使周围的环境更健康,制冷业一直都致力于设计出更好的制冷产品。效率——这个简单明了的字眼,已经在全世界每个产品生产厂的每个设计室里刮起一股旋风。制冷业也不例外。当然挑战在于,设计出的制冷系统要节能,降低成本,     

SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters

Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of the respiratory epithelium and compromises mucociliary clearance, thereby facilitating spread to the lungs and paving the way for secondary infections. A detailed understanding of mechanism involved in ciliary loss and subsequent regeneration is crucial to assess the possible long-term consequences of COVID-19. The aim of this study was to characterize the sequence of histological and ultrastructural changes observed in the ciliated epithelium during and after SARS-CoV-2 infection in the golden Syrian hamster model. We show that acute infection induces a severe, transient loss of cilia, which is, at least in part, caused by cilia internalization. Internalized cilia colocalize with membrane invaginations, facilitating virus entry into the cell. Infection also results in a progressive decline in cells expressing the regulator of ciliogenesis FOXJ1, which persists beyond virus clearance and the termination of inflammatory changes. Ciliary loss triggers the mobilization of p73⁺ and CK14⁺ basal cells, which ceases after regeneration of the cilia. Although ciliation is restored after two weeks despite the lack of FOXJ1, an increased frequency of cilia with ultrastructural alterations indicative of secondary ciliary dyskinesia is observed. In summary, the work provides new insights into SARS-CoV-2 pathogenesis and expands our understanding of virally induced damage to defense mechanisms in the conducting airways.     

Energy Efficient Cloud Service Provisioning: Keeping Data Center Granularity in Perspective

The cost of power and its associated delivery are becoming significant factors in the total expenditure of large-scale data centers. Numerous techniques have been proposed to address the energy efficiency issue in cloud systems. Recently, some efforts have been made to decentralize the cloud via distributing data centers in diverse geographical positions, at different scales. In this paper, we elaborate on the energy effectiveness of service provisioning on different cloud architectures, from a mega-data center to a nano data center, which provides the extreme decentralization in terms of cloud architecture, as well as P2P-clouds or community network clouds. We study the energy consumption through an analytical and simulation framework for video streaming and MapReduce applications.     

Finite multidimensional behaviors

We study finitely generated and finite systems defined by linear partial difference equations with constant coefficients in a Noetherian ring. The two notions coincide for finite rings, and we show that all finite systems exhibit certain periodicity properties. For the particular case of systems over the ring of integers modulo m?>?1, which is important in coding theory, a method is given for determining the number of trajectories, using Gr?bner basis techniques.     

Accelerating protein release from microparticles for regenerative medicine applications

There is a need to control the spatio-temporal release kinetics of growth factors in order to mitigate current usage of high doses. A novel delivery system, capable of providing both structural support and controlled release kinetics, has been developed from PLGA microparticles. The inclusion of a hydrophilic PLGA–PEG–PLGA triblock copolymer altered release kinetics such that they were decoupled from polymer degradation. A quasi zero order release profile over four weeks was produced using 10% w/w PLGA–PEG–PLGA with 50:50 PLGA whereas complete and sustained release was achieved over ten days using 30% w/w PLGA–PEG–PLGA with 85:15 PLGA and over four days using 30% w/w PLGA–PEG–PLGA with 50:50 PLGA. These three formulations are promising candidates for delivery of growth factors such as BMP-2, PDGF and VEGF. Release profiles were also modified by mixing microparticles of two different formulations providing another route, not previously reported, for controlling release kinetics. This system provides customisable, localised and controlled delivery with adjustable release profiles, which will improve the efficacy and safety of recombinant growth factor delivery.