Doppler echocardiographic assessment of left ventricular diastolic function in myotonic dystrophy

To determine the increased production and release of vascular endothelial growth factor (VEGF) from the retina in the eye with non-angiogenic retinal detachment in which relative blood supply disturbance may be present, the concentration of VEGF in subretinal fluid and vitreous fluid collected from the eyes was investigated by enzyme linked immunospecific assay. The average concentration of VEGF was 0.5 +/- 1.1 ng/ml (mean +/- standard deviation) in nine samples of vitreous fluid collected from proliferative retinal detachment, and was 1.2 +/- 1.2 ng/ml in eleven samples of subretinal fluid from rhegmatogenous retinal detachment. The concentration of VEGF in six samples of vitreous fluid from angiogenic diabetic eyes (5.0 +/- 2.8 ng/ml) was significantly higher than in the samples from eyes with retinal detachment. The results suggest that the relative ischemic insult to the detached retina increases the release of VEGF into the vitreous cavity and subretinal space. The increased concentration of VEGF does not induce remarkable angiogenesis since the concentration is lower than the biological threshold, or the effect is modulated by inhibitors.     

Thermodynamic properties of the Pd77.5Cu6Si16.5 undercooled liquid

Proper understanding of glass formation implies the knowledge of the thermodynamics of the undercooled melts. Specifically, high values of the excess specific heat of the liquid are expected for good glass-formers. Extending the work of Gillessen and Herlach [F. Gillessen, D.M. Herlach, J. Non-Cryst. Solids 117–118 (1990) 555–558], we re-propose a calculation of the temperature dependence of entropy difference between amorphous-liquid and crystal states.An amorphous Pd_77.5Cu₆Si_16.5 alloy has been produced by injection casting in a cylindrical copper mould. DSC measurements in the liquid, amorphous and crystalline states were performed with samples sliced from the cylinder to determine the heat of fusion, of crystallization and the difference in specific heat capacity between amorphous-liquid and crystal phases. These thermodynamic quantities are used to calculate the thermodynamic functions of the liquid-glass with reference to the equilibrium crystal mixture. The data are compared to those of other bulk glass-formers in terms of fragility plots.     

Measurement of thermophysical properties of liquid metallic alloys in a ground- and microgravity based research programme — theThermoLab project

The ThermoLab project is concerned with the measurement of the thermophysical properties of industrial alloys in the liquid phase. The project combines long and short duration microgravity measurements based on containerless processing with an electromagnetic levitation device and a ground based experimental programme using conventional and containerless processing techniques. An overview of the project and representative results from the ground based experimental programme are given. Alloys investigated included Ni-based, Fe-based, a Cu-Sn-Mg alloy and a γ-TiAl alloy.     

碳酸盐台地内部滩相薄储集层预测——以四川盆地威远地区寒武系洗象池群为例

以四川盆地威远地区中上寒武统洗象池群颗粒滩储集层为例,结合储集层成因机制分析,探寻预测滩相薄储集层分布的地质方法.滩相储集层发育受颗粒滩厚度控制,而颗粒滩的沉积速率和规模与微地貌高地密切相关,微地貌高地在稳定构造背景下可以较长时间继承发展.据此,提出了利用相对较短时间内形成的、以颗粒岩沉积为主的近等时地质体的厚度变化近似刻画沉积期微古地貌和储集层发育概率的方法,并在资料条件极差的威远地区中上寒武统洗象池群建立了滩相薄储集层预测地质方法.利用该方法对研究区滩相薄储集层分布进行了预测,与后期钻探实践结果对比,该方法预测效果良好,可为滩相薄储集层的勘探提供参考依据.图9参22     

Deep Transcranial Magnetic Stimulation Affects Gut Microbiota Composition in Obesity: Results of Randomized Clinical Trial

Growing evidence highlights the crucial role of gut microbiota in affecting different aspects of obesity. Considering the ability of deep transcranial magnetic stimulation (dTMS) to modulate the cortical excitability, the reward system, and, indirectly, the autonomic nervous system (ANS), we hypothesized a potential role of dTMS in affecting the brain-gut communication pathways, and the gut microbiota composition in obesity. In a hospital setting, 22 subjects with obesity (5 M, 17 F; 44.9 ± 2.2 years; BMI 37.5 ± 1.0 kg/m²) were randomized into three groups receiving 15 sessions (3 per week for 5 weeks) of high frequency (HF), low frequency (LF) dTMS, or sham stimulation. Fecal samples were collected at baseline and after 5 weeks of treatment. Total bacterial DNA was extracted from fecal samples using the QIAamp DNA Stool Mini Kit (Qiagen, Italy) and analyzed by a metagenomics approach (Ion Torrent Personal Genome Machine). After 5 weeks, a significant weight loss was found in HF (HF: −4.1 ± 0.8%, LF: −1.9 ± 0.8%, sham: −1.3 ± 0.6%, p = 0.042) compared to LF and sham groups, associated with a decrease in norepinephrine compared to baseline (HF: −61.5 ± 15.2%, p < 0.01; LF: −31.8 ± 17.1%, p < 0.05; sham: −35.8 ± 21.0%, p > 0.05). Furthermore, an increase in Faecalibacterium (+154.3% vs. baseline, p < 0.05) and Alistipes (+153.4% vs. baseline, p < 0.05) genera, and a significant decrease in Lactobacillus (−77.1% vs. baseline, p < 0.05) were found in HF. Faecalibacterium variations were not significant compared to baseline in the other two groups (LF: +106.6%, sham: +27.6%; p > 0.05) as well as Alistipes (LF: −54.9%, sham: −15.1%; p > 0.05) and Lactobacillus (LF: −26.0%, sham: +228.3%; p > 0.05) variations. Norepinephrine change significantly correlated with Bacteroides (r² = 0.734; p < 0.05), Eubacterium (r² = 0.734; p < 0.05), and Parasutterella (r² = 0.618; p < 0.05) abundance variations in HF. In conclusion, HF dTMS treatment revealed to be effective in modulating gut microbiota composition in subjects with obesity, reversing obesity-associated microbiota variations, and promoting bacterial species representative of healthy subjects with anti-inflammatory properties.     

Power-to-gas leverage effect on power-to-heat application for urban renewable thermal energy systems

High Renewable Energy Sources (RES) share in energy systems entails environmental advantages in its use but drawbacks in its distribution, management and effectiveness. The interconnection between electricity, heat and transport sector seems to be a comprehensive answer. Its actual link is on-going and, currently, involves electricity and heat. Indeed, Power to Heat (P2H) is the strategy of meeting the heating demand by supplying electricity to feed Heat Pump (HP). Their higher efficiency compared to fossil fuel boilers requires a further check in the quality of the heating demand to meet, i.e. the temperature levels. Great part of current building stock calls for High Temperature (HT) Heat which is not affordable by HP maintaining their Coefficient of Performance. To face this issue, RES can be used to produce synthetic fuels for feeding existing energy systems, the so-called Power-to-Gas option. In this way, greening the fuel supply can be seen as the best option for meeting HT heating demand while, Medium and Low Temperature are met by HP. Therefore, two technological scenarios, P2H and its combination with P2G, are presented and assessed in three reference Urban Energy Systems. The authors investigated on the impact of RES share increase from 25% up to 50% in the electricity mix with the objective function of Primary Energy Consumption (PEC). The outcomes of twenty-four energy scenarios, eight for each Reference City were assessed also through the value of delivered Renewable Heat. Finally, the leverage effect of P2G on the system is evaluated in terms of renewable heat contribution.     

Thermal and mechanical behavior of thermoplastic composites reinforced with fibers enzymatically extracted from Ampelodesmos mauritanicus

This work investigates the morphology, the thermal, and mechanical properties of technical fibers extracted from the Ampelodesmos mauritanicus (Diss) grass using a process that combines mechanical, mild chemical, and enzymatic steps. The structure and the thermal stability of Diss fibers make them suitable as a reinforcing filler in polymer composites, which was assessed by manufacturing biocomposites with improved stiffness and a tensile strength not degraded by Diss fibers when compared to those of a commodity polymer and a biodegradable one, namely polypropylene and poly(lactic acid). This work confirms that enzyme mixtures obtained from commercially available products of relatively low cost can represent a simple and environmentally friendly means to extract less common natural fibers. POLYM. ENG. SCI., 59:2418–2428, 2019. © 2019 Society of Plastics Engineers