构成单片正弦波振荡器的可编程模拟电路

可编程逻辑器件为数字设计中复杂功能的实现提供了一种流行的方法。虽然制造商尚未提供能与VLSI数字电路复杂性相比拟的模拟电路,但现场可编程模拟电路正在信号调整和滤波应用中获得广泛采用。这些器件基于CMOS跨导及开关式电容放大器,可为相对复杂的设计问题提供一种便利的解决方案。Lattice     

2-Substituted penems with amino acid-related side chains: synthesis and antibacterial activity of a new series of beta-lactam antibiotics

A new series of 6-(hydroxyethyl)penems 2-substituted with amino acid-related side chains was synthesized. The nature of the amino acyl derivative proved to be crucial both from a synthetic point of view, as beta-lactam ring opening can compete with C-2 nucleophilic substitution, and for antibacterial activity. Primary amino acid amides emerged as the most suitable side chains for enhancing permeability through a Gram-negative outer membrane. In vitro activity of the new 2-[(aminoamido)methyl]penems 3a-u was influenced by the nature and position of the amide moiety, the ring size for cyclic amides, and the configuration of the amino acid. Compounds bearing amides derived from small N-methyl amino acids (such as 3a) or from cyclic amino acids (such as prolinamide 3p and 4-hydroxyprolinamide 3r) showed broad spectrum in vitro activity against both Gram-positive and Gram-negative microorganisms.     

Selectivity in capillary electrophoresis: the use of proteins

Proteins, by their very diverse nature, provide a wide variety of options for generating selectivity in capillary electrophoresis (CE). Their use in different modes of CE will be considered in this review. Proteins added in solution to the background electrolyte allow separations to be made in a similar fashion to other electrokinetic chromatography methods, e.g., micellar separations. Alternatively, different immobilization schemes can be used to secure proteins within the capillary; these have included capillary electrochromatography with the protein grafted onto a silica support, or immobilization of the protein within a gel structure. Compounds varying in size from small inorganic ions to biopolymers may be bound by proteins. There is the potential for any sort of intermolecular interaction to play a role in the binding process (e.g., hydrophobic interactions, electrostatic interactions, etc.). Very specific high-affinity binding often occurs, but also there is often weaker, non-selective binding. Frequently the interactions of chiral compounds with proteins are stereoselective. Obtaining chiral selectivity has been one of the main applications of protein selectors in CE, and this use will be emphasized here in a discussion structured by type of protein. As well as utilizing the selectivity of proteins to develop separations, the role of CE in investigating ligand-protein interactions will be emphasized.     

Heavy metal removal from winery wastewater in the case of restrictive discharge regulation.

In most cases of winery effluent, the heavy metal content, especially zinc (Zn) and copper (Cu), does not meet the limits for the discharge as imposed by the most restrictive regulations at international level (0.4 mgCu/L and 1.0 mgZn/L in the Italian regulations). An alternative for the reduction of Cu and Zn is the on-site pre-treatment of wastewater at the winery in order to meet the limits for the discharge into the public sewerage. The purpose of this study is to evaluate the effectiveness of a pre-treatment based on chemical precipitation with chelating agents (TMT: 2,4,6-trimercaptotriazine), for the reduction of Cu and Zn from raw winery wastewater. The chemical precipitation was optimised at lab-scale through jar tests in order to evaluate the optimal dosages. An average dosage equal to 0.84 mL of TMT (15%) for 1 mg of Cu removed was estimated. Furthermore, the efficiency of the on-site chemical pre-treatment was investigated at pilot scale. The results confirmed the feasibility of using TMT treatment for the reduction of Cu and Zn in order to meet the limits for discharge into the sewerage. Contextually to the removal of heavy metals, the chemical pre-treatment allowed us to obtain the reduction of particulate COD and TSS. Finally, the costs for the operation and the management of the on-site pre-treatment were evaluated.     

Fatigue crack growth in the welding nugget of FSW joints of a 6060 aluminum alloy

Friction stir welded butt joints were performed on 8 mm thick sheets made of AA6060 T6 aluminum alloy by means of a CNC machine tool, at feed rates between 117 and 683 mm/min and tool rotational speed between 838 and 1262 rpm. Tensile tests, metallographic analyses and micro-Vickers tests were carried out to evaluate the mechanical properties of the joints as a function of the process parameters. The fatigue behavior was studied by means of crack growth tests performed according to ASTM E647 standard on CT specimens, with propagation in the middle of joint along the weld nugget. The results show the influence of welding process parameters on mechanical properties and fatigue behavior. Reduction of UTS of about 20–30% with respect to base material occurred with rupture in the softened zone of welding, usually HAZ. In this range, slight variations of joint efficiency were observed with f/S ratio, while the width of the softening area increases for decreasing values of this parameter. Fatigue crack growth was always slower than that in the base material at low ΔK below 12 MPa m^1/2. The effect of non-optimal welding parameters was evident at intermediate and high ΔK, due to defects, such as tunnels, that cause dramatic increase of propagation rate up to five times higher than the base material.     

Mediating the intersections of organizational routines during the introduction of a health IT system

Public interest in the quality and safety of health care has spurred examination of specific organizational routines believed to yield risk in health care work. Medication administration routines, in particular, have been the subject of numerous improvement projects involving information technology development, and other forms of research and regulation. This study draws from ethnographic observation to examine how the common routine of medication administration intersects with other organizational routines, and why understanding such intersections is important. We present three cases describing intersections between medication administration and other routines, including a pharmacy routine, medication administration on the next shift and management reporting. We found that each intersection had ostensive and performative dimensions; and furthermore, that IT-enabled changes to one routine led to unintended consequences in its intersection with others, resulting in misalignment of ostensive and performative aspects of the intersection. Our analysis focused on the activities of a group of nurses who provide technology use mediation (TUM) before and after the rollout of a new health IT system. This research offers new insights on the intersection of organizational routines, demonstrates the value of analyzing TUM activities to better understand the relationship between IT introduction and changes in routines, and has practical implications for the implementation of technology in complex practice settings.     

A model for electrical fast transient analyses of the ITER NBI power supplies and the MAMuG accelerator

The design of ITER Neutral Beam Injector (NBI) is based on a five-stage electrostatic accelerator, known as Multi-Aperture Multi-Grid (MAMuG) and characterised by an overall acceleration voltage of ?1 MV. The MAMuG accelerator requires a five-stage power supply system under strict load protection requirements, being subjected in operation to breakdowns. In this paper a circuit model of ITER Neutral Beam Injector power supplies and MAMuG accelerator is illustrated, for the simulation of fast transients related to accelerator breakdowns in particular. Consideration of the high voltage involved and of the complex inductive and capacitive couplings implied careful assessment of stray parameters by calculations with finite element techniques. The circuit model, developed to address a number of design issues requiring simulations at system level, is now ready for use—the optimisation of passive protections being the most significant application.     

Modulation of Amyloid β-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is not restricted to the neuronal compartment but includes important interactions with immune cells, including microglia. Protein aggregates, common pathological hallmarks of AD, bind to pattern recognition receptors on microglia and trigger an inflammatory response, which contributes to disease progression and severity. In this context, curcumin is emerging as a potential drug candidate able to affect multiple key pathways implicated in AD, including neuroinflammation. Therefore, we studied the effect of curcumin and its structurally related analogues cur6 and cur16 on amyloid-β (Aβ)-induced microglia activation and neuronal cell death, as well as their effect on the modulation of Aβ aggregation. Primary cortical microglia and neurons were exposed to two different populations of Aβ42 oligomers (Aβ42Os) where the oligomeric state had been assigned by capillary electrophoresis and ultrafiltration. When stimulated with high molecular weight Aβ42Os, microglia released proinflammatory cytokines that led to early neuronal cell death. The studied compounds exerted an anti-inflammatory effect on high molecular weight Aβ42O-stimulated microglia and possibly inhibited microglia-mediated neuronal cell toxicity. Furthermore, the tested compounds demonstrated antioligomeric activity during the process of in vitro Aβ42 aggregation. These findings could be investigated further and used for the optimization of multipotent candidate molecules for AD treatment.