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Anca Cardoneanu Luana Andreea Macovei Alexandra Maria Burlui Ioana Ruxandra Mihai Ioana Bratoiu Ioana Irina Rezus Patricia Richter Bogdan-Ionel Tamba Elena Rezus 《International journal of molecular sciences》2023,24(1)
The temporomandibular joint (TMJ) is a specialized synovial joint that is crucial for the movement and function of the jaw. TMJ osteoarthritis (TMJ OA) is the result of disc dislocation, trauma, functional overburden, and developmental anomalies. TMJ OA affects all joint structures, including the articular cartilage, synovium, subchondral bone, capsule, ligaments, periarticular muscles, and sensory nerves that innervate the tissues. The present review aimed to illustrate the main pathomechanisms involving cartilage and bone changes in TMJ OA and some therapeutic options that have shown potential restorative properties regarding these joint structures in vivo. Chondrocyte loss, extracellular matrix (ECM) degradation, and subchondral bone remodeling are important factors in TMJ OA. The subchondral bone actively participates in TMJ OA through an abnormal bone remodeling initially characterized by a loss of bone mass, followed by reparative mechanisms that lead to stiffness and thickening of the condylar osteochondral interface. In recent years, such therapies as intraarticular platelet-rich plasma (PRP), hyaluronic acid (HA), and mesenchymal stem cell-based treatment (MSCs) have shown promising results with respect to the regeneration of joint structures or the protection against further damage in TMJ OA. Nevertheless, PRP and MSCs are more frequently associated with cartilage and/or bone repair than HA. According to recent findings, the latter could enhance the restorative potential of other therapies (PRP, MSCs) when used in combination, rather than repair TMJ structures by itself. TMJ OA is a complex disease in which degenerative changes in the cartilage and bone develop through intricate mechanisms. The regenerative potential of such therapies as PRP, MSCs, and HA regarding the cartilage and subchondral bone (alone or in various combinations) in TMJ OA remains a matter of further research, with studies sometimes obtaining discrepant results. 相似文献
23.
Luana Persano Sandra Molle Salvatore Girardo Antonio A. R. Neves Andrea Camposeo Ripalta Stabile Roberto Cingolani Dario Pisignano 《Advanced functional materials》2008,18(18):2692-2698
In this work we demonstrate the nanopatterning of nanocomposites made by luminescent zinc oxide nanoparticles and light‐emitting conjugated polymers by means of soft molding lithography. Vertical nanofluidics is exploited to overcome the polymer transport difficulties intrinsic in materials incorporating nanocrystals, and the rheology, fluorescence, absolute quantum yield, and emission directionality of the nanostructured composites are investigated. We study the effect of patterned gratings on the directionality of light emitted from the nanocomposites, finding evidence of the enhancement of forward emitted light, due to the printed wavelength‐scale periodicity. These results open new possibilities for the realization of nanopatterned devices based on hybrid organic‐inorganic systems. 相似文献
24.
Antonella Gori Cecilia Brunetti Luana Beatriz dos Santos Nascimento Giovanni Marino Lucia Guidi Francesco Ferrini Mauro Centritto Alessio Fini Massimiliano Tattini 《International journal of molecular sciences》2021,22(15)
Carotenoids and phenylpropanoids play a dual role of limiting and countering photooxidative stress. We hypothesize that their “antioxidant” function is prominent in plants exposed to summer drought, when climatic conditions exacerbate the light stress. To test this, we conducted a field study on Phillyrea latifolia, a Mediterranean evergreen shrub, carrying out daily physiological and biochemical analyses in spring and summer. We also investigated the functional role of the major phenylpropanoids in different leaf tissues. Summer leaves underwent the most severe drought stress concomitantly with a reduction in radiation use efficiency upon being exposed to intense photooxidative stress, particularly during the central hours of the day. In parallel, a significant daily variation in both carotenoids and phenylpropanoids was observed. Our data suggest that the morning-to-midday increase in zeaxanthin derived from the hydroxylation of ß-carotene to sustain non-photochemical quenching and limit lipid peroxidation in thylakoid membranes. We observed substantial spring-to-summer and morning-to-midday increases in quercetin and luteolin derivatives, mostly in the leaf mesophyll. These findings highlight their importance as antioxidants, countering the drought-induced photooxidative stress. We concluded that seasonal and daily changes in photosynthetic and non-photosynthetic pigments may allow P. latifolia leaves to avoid irreversible photodamage and to cope successfully with the Mediterranean harsh climate. 相似文献
25.
Saldanha Maria Christine Werba Araújo Luana Leal Fernandes Arcuri Rodrigo Vidal Mario Cesar Rodríguez de Carvalho Paulo Victor Rodrigues de Carvalho Ricardo José Matos 《Cognition, Technology & Work》2022,24(3):521-535
Cognition, Technology & Work - Modern organizations live in a context of political, economic, technological, social and environmental changes for which they need to be prepared to adapt and... 相似文献
26.
Luana N. Santos Mário H. Gonzalez Monise F. Moura George L. Donati Joaquim A. Nóbrega 《Food Analytical Methods》2016,9(3):624-629
This work describes the determination of aluminum in tea infusions and iced tea by tungsten coil atomic emission spectrometry (WCAES). The instrumentation is simple, inexpensive, and potentially portable. It uses a tungsten filament extracted from 150 W, 15 V commercially available slide projector light bulbs as electrothermal atomizer. A simple power supply that provides a constant potential is used to heat the coil. Tea infusions were directly analyzed by application of an optimized heating program. In order to avoid matrix interferences, the iced tea samples were diluted with an oxidizing mixture composed of hydrogen peroxide and nitric acid and also analyzed by a tailored heating program. Aluminum was quantified in all samples, and the results were in agreement with those obtained by inductively coupled plasma optical emission spectrometry at a 95 % confidence level. The limit of detection and the relative standard deviation for a solution containing 2.5 mg L?1 Al (n?=?10) were determined, and the values were 0.09 mg L?1 and 5.1 %, respectively. 相似文献
27.
Scheffer L Futerman AH Addadi L 《Chembiochem : a European journal of chemical biology》2007,8(18):2286-2294
A monoclonal antibody raised against mixed monolayers of 60:40 mol % cholesterol/C16-ceramide of known structure was used to label cholesterol/ceramide-rich domains in cell membranes. The antibody, Cer-Chol 405F specifically recognizes the mixed crystalline and homogeneous phase in monolayers, but it does not interact with either of the components separately. It interacts differently with mixed monolayers that contain ceramides of different acyl chain length. When used on cells, the antibody labeling is sensitive to changes in cholesterol and ceramide levels, as well as to over-expression of specific ceramides; this is in agreement with the results that were obtained on lipid monolayers. This represents a proof of concept of the applicability of a new approach to the structural characterization of lipid microdomains in cell membranes. The approach consists of raising antibodies that recognize specific structural organizations of lipids in artificial mixtures, characterizing the antibody/ordered domain complexes in vitro, and subsequently using them to detect the presence of the same (or similar) domains in cell membranes. 相似文献
28.
Ralph Gilles Michael Hofmann Yan Gao Frank Johnson Luana Iorio Michael Larsen Feng Liang Markus Hoelzel Bruno Barbier 《Metallurgical and Materials Transactions A》2010,41(5):1144-1150
The effects of tailoring FeCo alloys with addition of ternary elements Pt, Pd, Mn, Ir, and Re have been investigated. In the
composition range of 30 to 70 pct Co, FeCo alloys undergo a continuous order-disorder phase transition at a maximum temperature
of 730 °C at the equiatomic composition. The effects of temperature and composition on the degree of long-range order in six
alloys (Fe70Co30, Fe67Co30Pt3, Fe67Co30Pd3, Fe67Co30Mn3, Fe67Co30Ir3, and Fe67Co30Re3; at. pct) were compared using neutron diffraction. The transition goes along with growing of antiphase domains during the
heating process. 相似文献
29.
30.
Perinatal maternal high‐fat diet promotes alterations in hepatic lipid metabolism and resistance to the hypolipidemic effect of fish oil in adolescent rat offspring 下载免费PDF全文